Results 21 to 30 of about 5,128,022 (309)

Safety, activity, and immune correlates of anti-PD-1 antibody in cancer.

New England Journal of Medicine, 2012
BACKGROUND Blockade of programmed death 1 (PD-1), an inhibitory receptor expressed by T cells, can overcome immune resistance. We assessed the antitumor activity and safety of BMS-936558, an antibody that specifically blocks PD-1.
S. Topalian, F. Hodi, J. Brahmer, S. Gettinger, David C. Smith, David F. McDermott, J. Powderly, Richard D. Carvajal, J. Sosman, M. Atkins, P. Leming, D. Spigel, S. Antonia, L. Horn, Charles G. Drake, D. Pardoll, Lieping Chen, W. Sharfman, Robert A. Anders, J. Taube, T. McMiller, Haiying Xu, A. Korman, M. Jure-Kunkel, S. Agrawal, D. McDonald, G. Kollia, A. Gupta, J. Wigginton, M. Sznol   +29 more
semanticscholar   +1 more source

A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-2

Science, 2020
Hitting SARS-CoV-2 in a new spot A key target for therapeutic antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the spike protein, a trimeric protein complex with each monomer comprising an S1 and an S2 domain that ...
Xiangyang Chi, R. Yan, Jun Zhang, Guanying Zhang, Yuanyuan Zhang, Meng Hao, Zhe Zhang, Pengfei Fan, Yunzhu Dong, Yilong Yang, Zhengshan Chen, Yingying Guo, Jinlong Zhang, Yaning Li, Xiaohong Song, Yi Chen, L. Xia, L. Fu, L. Hou, Junjie Xu, Changming Yu, Jianmin Li, Qiang Zhou, Wei Chen   +23 more
semanticscholar   +1 more source

A comprehensive proteogenomic study of the human Brucella vaccine strain 104 M

BMC Genomics, 2017
Background Brucella spp. are Gram-negative, facultative intracellular pathogens that cause brucellosis in both humans and animals. The B. abortus vaccine strain 104 M is the only vaccine available in China for the prevention of brucellosis in humans ...
Xiaodong Zai, Qiaoling Yang, Kun Liu, Ruihua Li, Mengying Qian, Taoran Zhao, Yaohui Li, Ying Yin, Dayong Dong, Ling Fu, Shanhu Li, Junjie Xu, Wei Chen   +12 more
doaj   +1 more source

An integrated mammalian library approach for optimization and enhanced microfluidics-assisted antibody hit discovery

Artificial Cells, Nanomedicine, and Biotechnology, 2023
Recent years have seen the development of a variety of mammalian library approaches for display and secretion mode. Advantages include library approaches for engineering, preservation of precious immune repertoires and their repeated interrogation, as ...
Ramona Gaa, Kavita Kumari, Hannah Melina Mayer, Desislava Yanakieva, Shang-Pu Tsai, Saurabh Joshi, Ralf Guenther, Achim Doerner   +7 more
doaj   +1 more source

REGN-COV2, a Neutralizing Antibody Cocktail, in Outpatients with Covid-19

New England Journal of Medicine, 2020
Background Recent data suggest that complications and death from coronavirus disease 2019 (Covid-19) may be related to high viral loads. Methods In this ongoing, double-blind, phase 1–3 trial involving nonhospitalized patients with Covid-19, we ...
D. Weinreich, S. Sivapalasingam, Thomas D. Norton, Shazia Ali, Haitao Gao, R. Bhore, B. Musser, Y. Soo, D. Rofail, Joseph Im, C. Perry, C. Pan, R. Hosain, A. Mahmood, John D. Davis, K. Turner, A. Hooper, J. Hamilton, A. Baum, C. Kyratsous, Yunji Kim, A. Cook, W. Kampman, A. Kohli, Yessica Sachdeva, X. Graber, B. Kowal, T. Dicioccio, N. Stahl, L. Lipsich, N. Braunstein, G. Herman, G. Yancopoulos   +32 more
semanticscholar   +1 more source

Emerging new therapeutic antibody derivatives for cancer treatment

Signal Transduction and Targeted Therapy, 2022
Monoclonal antibodies constitute a promising class of targeted anticancer agents that enhance natural immune system functions to suppress cancer cell activity and eliminate cancer cells.
Shijie Jin, Yanping Sun, Xiaojie Liang, Xinyu Gu, Jiangtao Ning, Ying-chun Xu, Shuqing Chen, L. Pan   +7 more
semanticscholar   +1 more source

The Antibody Society’s antibody validation webinar series [PDF]

mAbs, 2020
In the wake of the reproducibility crisis and numerous discussions on how commercially available antibodies as research tool contribute to it, The Antibody Society developed a series of 10 webinars to address the issues involved. The webinars were delivered by speakers with both academic and commercial backgrounds.
Andrew Bradbury, C. Glenn Begley, Alejandra Solache, Giovanna Roncador, Andrew D. Chalmers, Cecilia Williams, Cecilia Williams, Fridtjof Lund-Johansen, Travis Hardcastle, Andreas Plückthun, Michael J. Taussig, Jan L.A. Voskuil, Aldrin V. Gomes, Simon L. Goodman, James S. Trimmer, Anita Bandrowski   +15 more
openaire   +6 more sources

GPI-Anchored Fibromodulin as a Novel Target in Chronic Lymphocytic Leukemia: Diagnostic and Therapeutic Implications [PDF]

Iranian Journal of Immunology, 2019
Background: We have previously reported the aberrant expression of Fibromodulin (FMOD) in patients with chronic lymphocytic leukemia (CLL). Although FMOD has been considered as a cytoplasmic or secretory protein, we discovered the cell surface expression
Lia Farahi, Fatemeh Ghaemimanesh, Saeideh Milani, Seyed Mohsen Razavi, Reza Hadavi, Ali Ahmad Bayat, Ali Salimi, Mohammad Mehdi Akhondi, Hodjattallah Rabbani   +8 more
doaj   +1 more source

Tropomyosin antibody: the specific localization of tropomyosin in nonmuscle cells [PDF]

, 1975
An antibody against purified chicken skeletal muscle tropomyosin is used in indirect immunofluorescence to visualize the localization of tropomyosin in a variety of nonmuscle cells.
Lazarides, Elias
core   +2 more sources

Challenges and developments in universal vaccine design against SARS-CoV-2 variants

npj Vaccines, 2022
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) had become a global concern because of its unexpectedly high pathogenicity and transmissibility.
Fangxin Zhao, Xiaodong Zai, Zhiling Zhang, Junjie Xu, Wei Chen   +4 more
doaj   +1 more source