Results 51 to 60 of about 5,128,022 (309)

The association between life events, social support, and antibody status following thymus-dependent and thymus-independent vaccinations in healthy young adults [PDF]

, 2005
This study determined whether stressful life events and social support were related to antibody status following both thymus-dependent and thymus-independent vaccinations. Life events in the previous year and customary social support were measured in 57
Burns, Victoria E., Carroll, Douglas, Drayson, Mark, Phillips, Anna C., Ring, Christopher   +4 more
core   +1 more source

Successful targeting of multidrug-resistant tumors with bispecific antibodies

mAbs
Multidrug resistance (MDR) hinders efficacious cancer chemotherapy. Overexpression of the P-glycoprotein (P-gp) efflux pump (EP) on cancer cells is a primary cause of MDR since it expels numerous anticancer drugs.
Raffaella Briante, Qianting Zhai, Suchismita Mohanty, Pingping Zhang, Alissa O’Connor, Hiwot Misker, Willie Wang, Cindy Tan, Mastewal Abuhay, Jessica Morgan, Richard Theolis, Paul Ponath, Robert Arathoon   +12 more
doaj   +1 more source

A novel one-step approach for the construction of yeast surface display Fab antibody libraries

Microbial Cell Factories, 2018
Background Yeast surface display (YSD) has proven to be a versatile platform technology for antibody discovery. However, the construction of antibody Fab libraries typically is a tedious three-step process that involves the generation of heavy chain as ...
Simon Rosowski, Stefan Becker, Lars Toleikis, Bernhard Valldorf, Julius Grzeschik, Deniz Demir, Iris Willenbücher, Ramona Gaa, Harald Kolmar, Stefan Zielonka, Simon Krah   +10 more
doaj   +1 more source

A novel built-in adjuvant metallothionein-3 aids protein antigens to induce rapid, robust, and durable immune responses

Frontiers in Immunology, 2022
Adjuvants are crucial components of vaccines that can enhance and modulate antigen-specific immune responses. Herein, we reported for the first time that human metallothionein-3 (MT3), a low molecular weight cysteine-rich metal-binding protein, was a ...
Ying Yin, Yanfei Gu, Xiaodong Zai, Ruihua Li, Xinjie Zhu, Rui Yu, Jun Zhang, Shuyi Wang, Yue Zhang, Jian Lin, Junjie Xu, Wei Chen   +11 more
doaj   +1 more source

Encephalitis with mGluR5 antibodies [PDF]

Neurology, 2018
To report the clinical features of 11 patients with metabotropic glutamate receptor 5 (mGluR5) antibody-associated encephalitis, immunoglobulin G (IgG) subclass, and effects of the antibodies on neuronal mGluR5 clusters.Clinical information was retrospectively obtained from referring physicians.
Spatola, Marianna, Sabater, Lidia, Heaney, Nicholas, Tubridy, Niall, Munteis Olivas, Elvira, Rosenfeld, Myrna R, Graus, Francesc, Dalmau, Josep, Planagumà, Jesús, Martínez-Hernandez, Eugenia, Armangué, Thaís, Prüss, Harald, Iizuka, Takahiro, Caparó Oblitas, Ruben L, Antoine, Jean-Christophe, Li, Richard   +15 more
openaire   +4 more sources

Regioselective and stoichiometrically controlled conjugation of photodynamic sensitizers to a HER2 targeting antibody fragment [PDF]

, 2014
The rapidly increasing interest in the synthesis of antibody–drug conjugates as powerful targeted anticancer agents demonstrates the growing appreciation of the power of antibodies and antibody fragments as highly selective targeting moieties.
Boyle, Ross W., Bryden, Francesca, Caddick, Stephen, Chudasama, Vijay, Maruani, Antoine, Savoie, Huguette, Smith, Mark E. B.   +6 more
core   +1 more source

Modelling bispecific monoclonal antibody interaction with two cell membrane targets indicates the importance of surface diffusion [PDF]

, 2016
We have developed a mathematical framework for describing a bispecific monoclonal antibody interaction with two independent membrane-bound targets that are expressed on the same cell surface.
Argungu, Maryam, Hadji, Aymen, Hawkins, Emma, McGinty, Sean, Nouri, Fatma Z., Sengers, Bram G., Sepp, Armin, Taylor, Adam, Weber, Andrew   +8 more
core   +1 more source

Development of a high yielding expression platform for the introduction of non-natural amino acids in protein sequences

mAbs, 2020
The ability to genetically encode non-natural amino acids (nnAAs) into proteins offers an expanded tool set for protein engineering. nnAAs containing unique functional moieties have enabled the study of post-translational modifications, protein ...
Gargi Roy, Jason Reier, Andrew Garcia, Tom Martin, Megan Rice, Jihong Wang, Meagan Prophet, Ronald Christie, William Dall’Acqua, Sanjeev Ahuja, Michael A Bowen, Marcello Marelli   +11 more
doaj   +1 more source

A Novel Anti-EGFR mAb Ame55 with Lower Toxicity and Better Efficacy than Cetuximab When Combined with Irinotecan

Journal of Immunology Research, 2019
To improve efficacy and minimize toxicity of EGFR inhibition treatment, we developed Ame55, a novel anti-EGFR IgG1 with lower affinity to EGFR than cetuximab (C225) from a human phage library.
Weiyi Qiu, Chang Zhang, Shuang Wang, Xiaoyan Yu, Qiong Wang, Dadi Zeng, Peng Du, Jinling Ma, Yiqiong Zheng, Bo Pang, Yunzhou Yu, Feng Long, Xiaobin Pang, Zhiwei Sun   +13 more
doaj   +1 more source

Versatile and rapid microfluidics-assisted antibody discovery

mAbs, 2021
Recent years have seen unparalleled development of microfluidic applications for antibody discovery in both academic and pharmaceutical research. Microfluidics can support native chain-paired library generation as well as direct screening of antibody ...
Ramona Gaa, Emmanuel Menang-Ndi, Shruti Pratapa, Christine Nguyen, Satyendra Kumar, Achim Doerner   +5 more
doaj   +1 more source