Comparability of six different immunoassays measuring
, 2021 Abigail Lamikanra +21 more
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Emerging role of ARHGAP29 in melanoma cell phenotype switching
Molecular Oncology, EarlyView.This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster +3 more
wiley +1 more source
Antibody and Antibody Mimetic Immunotherapeutics [PDF]
Future Medicinal Chemistry, 2017 Angeline N, Ta, Brian R, McNaughton
openaire +2 more sources
Molecular Oncology, EarlyView.In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern +7 more
wiley +1 more source
CLEC14a-HSP70-1A interaction regulates HSP70-1A-induced angiogenesis
Scientific Reports, 2017 CLEC14a (C-type lectin domain family 14 member) is a tumor endothelial cell marker protein that is known to play an important role in tumor angiogenesis, but the basic molecular mechanisms underlying this function have not yet been clearly elucidated. In
Jihye Jang +6 more
doaj +1 more source
Frontiers in Immunology, 2019 Myeloid-derived suppressor cells (MDSCs) play crucial roles in tumorigenesis and their inhibition is critical for successful cancer immunotherapy.
Dehong Yan +10 more
doaj +1 more source
Combination Therapy with Rituximab, Tofacitinib and Pirfenidone in a Patient with Rapid Progressive Interstitial Lung Disease (RP-ILD) Due to MDA5 Antibody-Associated Dermatomyositis: A Case Report [PDF]
, 2021 Tsai‐Hung Yen +3 more
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Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Mutation N856K in spike reduces fusogenicity and infectivity of Omicron BA.1
Signal Transduction and Targeted Therapy, 2023 Chunyun Sun +9 more
doaj +1 more source
Extracellular vesicles as modifiers of antibody‐drug conjugate efficacy
, 2021 Márk Barok +3 more
openalex +1 more source