Results 21 to 30 of about 798,539 (256)
Frontiers in Immunology, 2021 Staphylococcal enterotoxin B (SEB) simultaneously crosslinks MHC class II antigen and TCR, promoting proliferation of T cells and releasing a large number of toxic cytokines.
Ganggang Bai +7 more
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Prestige Antibodies™—Monospecific Antibodies Designed for Immunohistochemical Analysis [PDF]
BioTechniques, 2008 Well-characterized antibodies are essential tools for protein studies, global proteomics analysis, as well as for clinical diagnostics. However, although production of antibodies is a well-established process and a large number of antibodies are commercially available through many vendors, specific antibodies still do not exist for the majority of ...
Sara A. Gunnerås +3 more
openaire +7 more sources
Recent Progress in Antibody Epitope Prediction
Antibodies, 2023 Recent progress in epitope prediction has shown promising results in the development of vaccines and therapeutics against various diseases. However, the overall accuracy and success rate need to be improved greatly to gain practical application ...
Xincheng Zeng +3 more
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Frontiers in Chemistry, 2021 Galactose is a naturally occurring monosaccharide used to build complex glycans that has not been targeted for labeling as a metabolic reporter. Here, we characterize the cellular modification of proteins by using Ac46AzGal in a dose- and time-dependent ...
Jiajia Wang +12 more
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Computational Design of Epitope-Specific Functional Antibodies
Cell Reports, 2018 Summary: The ultimate goal of protein design is to introduce new biological activity. We propose a computational approach for designing functional antibodies by focusing on functional epitopes, integrating large-scale statistical analysis with multiple ...
Guy Nimrod +14 more
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Evolution of phage display libraries for therapeutic antibody discovery
mAbs, 2023 Monoclonal antibodies (mAbs) and their derivatives have emerged as one of the most important classes of biotherapeutics in recent decades. The success of mAb is due to their high versatility, high target specificity, excellent clinical safety profile ...
Yang Zhang
doaj +1 more source
mAbs, 2023 Prolactin (PRL) has recently been demonstrated to elicit female-selective nociceptor sensitization and increase pain-like behaviors in female animals.
Stephanie Maciuba +13 more
doaj +1 more source
Hallucinating structure-conditioned antibody libraries for target-specific binders
Frontiers in Immunology, 2022 Antibodies are widely developed and used as therapeutics to treat cancer, infectious disease, and inflammation. During development, initial leads routinely undergo additional engineering to increase their target affinity.
Sai Pooja Mahajan +5 more
doaj +1 more source
A Novel Human Antibody, HF, against HER2/erb-B2 Obtained by a Computer-Aided Antibody Design Method
Engineering, 2021 Fully human antibodies have minimal immunogenicity and safety profiles. At present, most potential antibody drugs in clinical trials are humanized or fully human.
Chunxia Qiao +10 more
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Monte Carlo Thompson sampling-guided design for antibody engineering
mAbs, 2023 Antibodies are one of the predominant treatment modalities for various diseases. To improve the characteristics of a lead antibody, such as antigen-binding affinity and stability, we conducted comprehensive substitutions and exhaustively explored their ...
Taro Kakuzaki +8 more
doaj +1 more source