Results 31 to 40 of about 837,409 (288)
Frontiers in Immunology, 2022 Single-domain antibodies (sdAbs) are a promising class of biotherapeutics with unique structural traits within their paratope region. The distribution of canonical conformations explored by their complementarity determining region (CDR) loops differs to ...
Francis Gaudreault +3 more
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Frontiers in Immunology, 2023 Antibodies, through their ability to target virtually any epitope, play a key role in driving the adaptive immune response in jawed vertebrates. The binding domains of standard antibodies are their variable light (VL) and heavy (VH) domains, both of ...
Bora Guloglu +3 more
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Frontiers in Immunology, 2021 Staphylococcal enterotoxin B (SEB) simultaneously crosslinks MHC class II antigen and TCR, promoting proliferation of T cells and releasing a large number of toxic cytokines.
Ganggang Bai +7 more
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Recent Progress in Antibody Epitope Prediction
Antibodies, 2023 Recent progress in epitope prediction has shown promising results in the development of vaccines and therapeutics against various diseases. However, the overall accuracy and success rate need to be improved greatly to gain practical application ...
Xincheng Zeng +3 more
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Design and Production of Bispecific Antibodies [PDF]
Antibodies, 2019 With the current biotherapeutic market dominated by antibody molecules, bispecific antibodies represent a key component of the next-generation of antibody therapy. Bispecific antibodies can target two different antigens at the same time, such as simultaneously binding tumor cell receptors and recruiting cytotoxic immune cells.
Qiong Wang +7 more
openaire +3 more sources
Frontiers in Chemistry, 2021 Galactose is a naturally occurring monosaccharide used to build complex glycans that has not been targeted for labeling as a metabolic reporter. Here, we characterize the cellular modification of proteins by using Ac46AzGal in a dose- and time-dependent ...
Jiajia Wang +12 more
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Computational Design of Epitope-Specific Functional Antibodies
Cell Reports, 2018 Summary: The ultimate goal of protein design is to introduce new biological activity. We propose a computational approach for designing functional antibodies by focusing on functional epitopes, integrating large-scale statistical analysis with multiple ...
Guy Nimrod +14 more
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Acquisition of antibody isotypes against Plasmodium falciparum blood stage antigens in a birth cohort. [PDF]
, 2010 Information on the period during which infants lose their maternally derived antibodies to malaria and begin to acquire naturally their own immune responses against parasite antigens is crucial for understanding when malaria vaccines may be best ...
Duah, NO +7 more
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Evolution of phage display libraries for therapeutic antibody discovery
mAbs, 2023 Monoclonal antibodies (mAbs) and their derivatives have emerged as one of the most important classes of biotherapeutics in recent decades. The success of mAb is due to their high versatility, high target specificity, excellent clinical safety profile ...
Yang Zhang
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Fv antibodies to aflatoxin B1 derived from a pre-immunized antibody phage display library system [PDF]
, 2002 The production and characterization of recombinant antibodies to aflatoxin B[SUB1] (AFB[SUB1]), a potent mycotoxin and carcinogen is described. The antibody fragments produced were then applied for use in a surface plasmon resonance-based biosensor ...
Daly, Stephen J. +6 more
core +1 more source