Results 21 to 30 of about 837,409 (288)

Addressing the antibody germline bias and its effect on language models for improved antibody design. [PDF]

Bioinformatics
Olsen TH, Moal IH, Deane CM.
europepmc   +2 more sources

Antibody-Drug Conjugates for Cancer Therapy

, 2023
Antibody-drug conjugates (ADCs) take advantage of the specificity of a monoclonal antibody to deliver a linked cytotoxic agent directly into a tumour cell.
Sagun Parakh (9493061), Adam Parslow (9493046), Andrew Scott (9483443), Fook-Thean Lee (9491234), Hui Gan (9477872)   +4 more
core   +2 more sources

AI-driven antibody design with generative diffusion models: current insights and future directions. [PDF]

Acta Pharmacol Sin
He XH, Li JR, Xu J, Shan H, Shen SY, Gao SH, Xu HE.   +6 more
europepmc   +2 more sources

Conformational Entropy as a Potential Liability of Computationally Designed Antibodies

Biomolecules, 2022
In silico antibody discovery is emerging as a viable alternative to traditional in vivo and in vitro approaches. Many challenges, however, remain open to enabling the properties of designed antibodies to match those produced by the immune system. A major
Thomas Löhr, Pietro Sormanni, Michele Vendruscolo   +2 more
doaj   +1 more source

Antibody design using deep learning: from sequence and structure design to affinity maturation. [PDF]

Brief Bioinform
Joubbi S, Micheli A, Milazzo P, Maccari G, Ciano G, Cardamone D, Medini D.   +6 more
europepmc   +2 more sources

In vivo pharmacokinetic enhancement of monomeric Fc and monovalent bispecific designs through structural guidance

Communications Biology, 2021
Lu Shan et al. present a structure-guided approach to engineer a monovalent form of the fragment crystallizable (Fc) region of an IgG4 antibody to adapt multiple versions of half-life extension modifications and bispecific targeting.
Lu Shan, Nydia Van Dyk, Nantaporn Haskins, Kimberly M. Cook, Kim L. Rosenthal, Ronit Mazor, Sonia Dragulin-Otto, Yu Jiang, Herren Wu, William F. Dall’Acqua, Martin J. Borrok, Melissa M. Damschroder, Vaheh Oganesyan   +12 more
doaj   +1 more source

Therapeutic Monoclonal Antibodies and Antibody Products, Their Optimization and Drug Design in Cancers [PDF]

, 2022
The book broadly deals with therapeutic monoclonal antibodies (mAbs) and various relevant topics, including different antibody formats such as Antibody–Drug Conjugates (ADC), bispecifics, nanoparticle-based mAbs and HER2+ cancers, immune checkpoint ...

core   +1 more source

Comparing Antibody Interfaces to Inform Rational Design of New Antibody Formats

Frontiers in Molecular Biosciences, 2022
As the current biotherapeutic market is dominated by antibodies, the design of different antibody formats, like bispecific antibodies and other new formats, represent a key component in advancing antibody therapy.
Monica L. Fernández-Quintero, Patrick K. Quoika, Florian S. Wedl, Clarissa A. Seidler, Katharina B. Kroell, Johannes R. Loeffler, Nancy D. Pomarici, Valentin J. Hoerschinger, Alexander Bujotzek, Guy Georges, Hubert Kettenberger, Klaus R. Liedl   +11 more
doaj   +1 more source

Evaluation of Molecular Simulations and Deep Learning Prediction of Antibodies’ Recognition of TRBC1 and TRBC2

Antibodies, 2023
T cell receptor β-chain constant (TRBC) is a promising class of cancer targets consisting of two highly homologous proteins, TRBC1 and TRBC2. Developing targeted antibody therapeutics against TRBC1 or TRBC2 is expected to eradicate the malignant T cells ...
Xincheng Zeng, Tianqun Wang, Yue Kang, Ganggang Bai, Buyong Ma   +4 more
doaj   +1 more source

Structure‐based computational design of antibody mimetics: challenges and perspectives

FEBS Open Bio
The design of antibody mimetics holds great promise for revolutionizing therapeutic interventions by offering alternatives to conventional antibody therapies.
Elton J. F. Chaves, Danilo F. Coêlho, Carlos H. B. Cruz, Emerson G. Moreira, Júlio C. M. Simões, Manassés J. Nascimento‐Filho, Roberto D. Lins   +6 more
doaj   +2 more sources