Results 21 to 30 of about 10,558,921 (293)

Comparing Antibody Interfaces to Inform Rational Design of New Antibody Formats

Frontiers in Molecular Biosciences, 2022
As the current biotherapeutic market is dominated by antibodies, the design of different antibody formats, like bispecific antibodies and other new formats, represent a key component in advancing antibody therapy.
Monica L. Fernández-Quintero, Patrick K. Quoika, Florian S. Wedl, Clarissa A. Seidler, Katharina B. Kroell, Johannes R. Loeffler, Nancy D. Pomarici, Valentin J. Hoerschinger, Alexander Bujotzek, Guy Georges, Hubert Kettenberger, Klaus R. Liedl   +11 more
doaj   +1 more source

Evaluation of Molecular Simulations and Deep Learning Prediction of Antibodies’ Recognition of TRBC1 and TRBC2

Antibodies, 2023
T cell receptor β-chain constant (TRBC) is a promising class of cancer targets consisting of two highly homologous proteins, TRBC1 and TRBC2. Developing targeted antibody therapeutics against TRBC1 or TRBC2 is expected to eradicate the malignant T cells ...
Xincheng Zeng, Tianqun Wang, Yue Kang, Ganggang Bai, Buyong Ma   +4 more
doaj   +1 more source

Antibody design using deep learning: from sequence and structure design to affinity maturation. [PDF]

Brief Bioinform
Joubbi S, Micheli A, Milazzo P, Maccari G, Ciano G, Cardamone D, Medini D.   +6 more
europepmc   +2 more sources

Coevolved Canonical Loops Conformations of Single-Domain Antibodies: A Tale of Three Pockets Playing Musical Chairs

Frontiers in Immunology, 2022
Single-domain antibodies (sdAbs) are a promising class of biotherapeutics with unique structural traits within their paratope region. The distribution of canonical conformations explored by their complementarity determining region (CDR) loops differs to ...
Francis Gaudreault, Christopher R. Corbeil, Enrico O. Purisima, Traian Sulea   +3 more
doaj   +1 more source

Specific attributes of the VL domain influence both the structure and structural variability of CDR-H3 through steric effects

Frontiers in Immunology, 2023
Antibodies, through their ability to target virtually any epitope, play a key role in driving the adaptive immune response in jawed vertebrates. The binding domains of standard antibodies are their variable light (VL) and heavy (VH) domains, both of ...
Bora Guloglu, Bora Guloglu, Bora Guloglu, Charlotte M. Deane   +3 more
doaj   +1 more source

Computational Construction of a Single-Chain Bi-Paratopic Antibody Allosterically Inhibiting TCR-Staphylococcal Enterotoxin B Binding

Frontiers in Immunology, 2021
Staphylococcal enterotoxin B (SEB) simultaneously crosslinks MHC class II antigen and TCR, promoting proliferation of T cells and releasing a large number of toxic cytokines.
Ganggang Bai, Yanhong Ge, Yuhong Su, Shuo Chen, Xingcheng Zeng, Huixia Lu, Buyong Ma, Buyong Ma   +7 more
doaj   +1 more source

Perspective: the gist of public tender for service design [PDF]

, 2018
Governments around the world are increasingly formalising design as an innovative approach to renew public services. In this development, the capabilities of external service design consultancies often play an important part, which calls for new insights
Person, Oscar, Seungho Park-Lee, Oscar Person, Park-Lee, Seungho   +3 more
core   +2 more sources

Recent Progress in Antibody Epitope Prediction

Antibodies, 2023
Recent progress in epitope prediction has shown promising results in the development of vaccines and therapeutics against various diseases. However, the overall accuracy and success rate need to be improved greatly to gain practical application ...
Xincheng Zeng, Ganggang Bai, Chuance Sun, Buyong Ma   +3 more
doaj   +1 more source

Design and Production of Bispecific Antibodies [PDF]

Antibodies, 2019
With the current biotherapeutic market dominated by antibody molecules, bispecific antibodies represent a key component of the next-generation of antibody therapy. Bispecific antibodies can target two different antigens at the same time, such as simultaneously binding tumor cell receptors and recruiting cytotoxic immune cells.
Qiong Wang, Yiqun Chen, Jaeyoung Park, Xiao Liu, Yifeng Hu, Tiexin Wang, Kevin McFarland, Michael J. Betenbaugh   +7 more
openaire   +3 more sources

The Metabolic Chemical Reporter Ac46AzGal Could Incorporate Intracellular Protein Modification in the Form of UDP-6AzGlc Mediated by OGT and Enzymes in the Leloir Pathway

Frontiers in Chemistry, 2021
Galactose is a naturally occurring monosaccharide used to build complex glycans that has not been targeted for labeling as a metabolic reporter. Here, we characterize the cellular modification of proteins by using Ac46AzGal in a dose- and time-dependent ...
Jiajia Wang, Jiajia Wang, Biao Dou, Lu Zheng, Wei Cao, Peiyu Dong, Yingyi Chen, Xueke Zeng, Yinhang Wen, Wenxuan Pan, Jing Ma, Jingying Chen, Xia Li   +12 more
doaj   +1 more source