Revolutionizing oncology: the role of Artificial Intelligence (AI) as an antibody design, and optimization tools [PDF]
Biomarker ResearchAntibodies play a crucial role in defending the human body against diseases, including life-threatening conditions like cancer. They mediate immune responses against foreign antigens and, in some cases, self-antigens.
Varun Dewaker +5 more
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AI-based IsAb2.0 for antibody design. [PDF]
Brief BioinformAbstract Therapeutic antibody design has garnered widespread attention, highlighting its interdisciplinary importance. Advancements in technology emphasize the critical role of designing nanobodies and humanized antibodies in antibody engineering. However, current experimental methods are costly and time-consuming.
Liang T +10 more
europepmc +3 more sources
, 2013 Antibodies are a class of proteins vital in mediating immune responses in vertebrates. Their binding site is highly malleable, allowing them to bind virtually any antigen. The versatility of antibody binding sites has received much attention from the pharmaceutical industry, marking them out as the most important category of biopharmaceuticals.
Krawczyk, Konrad
openaire +4 more sources
Current Advancements in Addressing Key Challenges of Therapeutic Antibody Design, Manufacture, and Formulation [PDF]
Antibodies, 2019 Therapeutic antibody technology heavily dominates the biologics market and continues to present as a significant industrial interest in developing novel and improved antibody treatment strategies.
Vicki Sifniotis +3 more
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IsAb: a computational protocol for antibody design. [PDF]
Brief Bioinform, 2021 Liang T +7 more
europepmc +2 more sources
Toward real-world automated antibody design with combinatorial Bayesian optimization. [PDF]
Cell Rep Methods, 2023 Khan A +14 more
europepmc +2 more sources
Antibody structure and engineering considerations for the design and function of Antibody Drug Conjugates (ADCs) [PDF]
OncoImmunology, 2018 Antibody-drug conjugates (ADCs) are emerging as effective tools in cancer therapy, combining the antibody's exquisite specificity for the target antigen-expressing cancer cell together with the cytotoxic potency of the payload.
Ricarda M. Hoffmann +10 more
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Antibody Profiling: Kinetics with Native Biomarkers for Diagnostic Assay and Drug Developments
Biosensors, 2023 Despite remarkable progress in applied Surface Plasmon Resonance (SPR)-based methods, concise monitoring of kinetic properties for native biomarkers from patient samples is still lacking.
Ute Jucknischke +4 more
doaj +1 more source
A platform for antibody design
, 2022 Antibodies are specialized proteins produced by our adaptive immune system to identify and neutralize specific molecules (antigens) of foreign objects, such as pathogenic microorganisms or infected cells. Due to their chemical specificity and sensitivity, antibodies are widely used in biomedical research and to treat many diseases due to their high ...
Díaz Rovira, Anna Maria +1 more
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Rapid identification of neutralizing antibodies against SARS-CoV-2 variants by mRNA display
Cell Reports, 2022 Summary: The increasing prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with the ability to escape existing humoral protection conferred by previous infection and/or immunization necessitates the discovery of broadly ...
Shiho Tanaka +14 more
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