Results 11 to 20 of about 10,558,921 (293)

A disruptive clickable antibody design for the generation of antibody-drug conjugates. [PDF]

Antib Ther, 2023
Abstract Background Antibody-drug conjugates are cancer therapeutics that combine specificity and toxicity. A highly cytotoxic drug is covalently attached to an antibody that directs it to cancer cells.
Rakotoarinoro N, Dyck YFK, Krebs SK, Assi MK, Parr MK, Stech M.   +5 more
europepmc   +4 more sources

Computational antibody design [PDF]

, 2013
Antibodies are a class of proteins vital in mediating immune responses in vertebrates. Their binding site is highly malleable, allowing them to bind virtually any antigen. The versatility of antibody binding sites has received much attention from the pharmaceutical industry, marking them out as the most important category of biopharmaceuticals.
Krawczyk, Konrad
openaire   +3 more sources

IsAb: a computational protocol for antibody design. [PDF]

Brief Bioinform, 2021
Liang T, Chen H, Yuan J, Jiang C, Hao Y, Wang Y, Feng Z, Xie XQ.   +7 more
europepmc   +2 more sources

Antibody Profiling: Kinetics with Native Biomarkers for Diagnostic Assay and Drug Developments

Biosensors, 2023
Despite remarkable progress in applied Surface Plasmon Resonance (SPR)-based methods, concise monitoring of kinetic properties for native biomarkers from patient samples is still lacking.
Ute Jucknischke, Sebastian Friebe, Markus Rehle, Laura Quast, Sven H. Schmidt   +4 more
doaj   +1 more source

Exploring the design applications of key emerging materials from natural sciences through a design ideation workshop [PDF]

, 2023
10th Congress of the International Association of Societies of Design Research (IASDR 2023) 9-13 October 2023, Milan, Italy202405 bcchVersion of ...
Wang, X, Tufail, M, Leung, Sai Yin, Park, Hyunyim, Tian, A, Uzma, S, Kim, KM, Kim, KwanMyung, Wang, Xinyi, Tufail, Muhammad, Li, X, Tian, Aichu, Leung, SY, Park, H, Li, Xinye, Uzma, Sahr   +15 more
core   +1 more source

Rapid identification of neutralizing antibodies against SARS-CoV-2 variants by mRNA display

Cell Reports, 2022
Summary: The increasing prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with the ability to escape existing humoral protection conferred by previous infection and/or immunization necessitates the discovery of broadly ...
Shiho Tanaka, C. Anders Olson, Christopher O. Barnes, Wendy Higashide, Marcos Gonzalez, Justin Taft, Ashley Richardson, Marta Martin-Fernandez, Dusan Bogunovic, Priyanthi N.P. Gnanapragasam, Pamela J. Bjorkman, Patricia Spilman, Kayvan Niazi, Shahrooz Rabizadeh, Patrick Soon-Shiong   +14 more
doaj   +1 more source

Advances in Antibody Design. [PDF]

Annu Rev Biomed Eng, 2015
The use of monoclonal antibodies as therapeutics requires optimizing several of their key attributes. These include binding affinity and specificity, folding stability, solubility, pharmacokinetics, effector functions, and compatibility with the attachment of additional antibody domains (bispecific antibodies) and cytotoxic drugs (antibody–drug ...
Tiller KE, Tessier PM.
europepmc   +4 more sources

Conformational Entropy as a Potential Liability of Computationally Designed Antibodies

Biomolecules, 2022
In silico antibody discovery is emerging as a viable alternative to traditional in vivo and in vitro approaches. Many challenges, however, remain open to enabling the properties of designed antibodies to match those produced by the immune system. A major
Thomas Löhr, Pietro Sormanni, Michele Vendruscolo   +2 more
doaj   +1 more source

In vivo pharmacokinetic enhancement of monomeric Fc and monovalent bispecific designs through structural guidance

Communications Biology, 2021
Lu Shan et al. present a structure-guided approach to engineer a monovalent form of the fragment crystallizable (Fc) region of an IgG4 antibody to adapt multiple versions of half-life extension modifications and bispecific targeting.
Lu Shan, Nydia Van Dyk, Nantaporn Haskins, Kimberly M. Cook, Kim L. Rosenthal, Ronit Mazor, Sonia Dragulin-Otto, Yu Jiang, Herren Wu, William F. Dall’Acqua, Martin J. Borrok, Melissa M. Damschroder, Vaheh Oganesyan   +12 more
doaj   +1 more source

Addressing the antibody germline bias and its effect on language models for improved antibody design. [PDF]

Bioinformatics
Olsen TH, Moal IH, Deane CM.
europepmc   +2 more sources