Results 41 to 50 of about 10,558,921 (293)

Determinant moments for the design management occurrence in fashion industry [PDF]

, 2018
Design management has occupied a privileged place in debates related to the field of design and innovation in fashion industry. The apparel industry, in particular, presents a dynamic character, requiring constant updates on raw materials, changes in ...
Libânio, Cláudia de Souza, Amaral, Fernando Goncalves, Migowski, Sérgio Almeida, Fernando Gonçalves Amaral, Sérgio Almeida Migowski, Cláudia de Souza Libânio   +5 more
core   +1 more source

Hallucinating structure-conditioned antibody libraries for target-specific binders

Frontiers in Immunology, 2022
Antibodies are widely developed and used as therapeutics to treat cancer, infectious disease, and inflammation. During development, initial leads routinely undergo additional engineering to increase their target affinity.
Sai Pooja Mahajan, Jeffrey A. Ruffolo, Rahel Frick, Jeffrey J. Gray, Jeffrey J. Gray, Jeffrey J. Gray   +5 more
doaj   +1 more source

Prestige Antibodies™—Monospecific Antibodies Designed for Immunohistochemical Analysis [PDF]

BioTechniques, 2008
Well-characterized antibodies are essential tools for protein studies, global proteomics analysis, as well as for clinical diagnostics. However, although production of antibodies is a well-established process and a large number of antibodies are commercially available through many vendors, specific antibodies still do not exist for the majority of ...
Sara A. Gunnerås, Charlotta Agaton, Soraya Djerbi, Marianne Hansson   +3 more
openaire   +7 more sources

A Novel Human Antibody, HF, against HER2/erb-B2 Obtained by a Computer-Aided Antibody Design Method

Engineering, 2021
Fully human antibodies have minimal immunogenicity and safety profiles. At present, most potential antibody drugs in clinical trials are humanized or fully human.
Chunxia Qiao, Ming Lv, Xinying Li, Xiaoling Lang, Shouqin Lv, Mian Long, Yan Li, Shusheng Geng, Zhou Lin, Beifen Shen, Jiannan Feng   +10 more
doaj   +1 more source

Monte Carlo Thompson sampling-guided design for antibody engineering

mAbs, 2023
Antibodies are one of the predominant treatment modalities for various diseases. To improve the characteristics of a lead antibody, such as antigen-binding affinity and stability, we conducted comprehensive substitutions and exhaustively explored their ...
Taro Kakuzaki, Hikaru Koga, Shuuki Takizawa, Shoichi Metsugi, Hirotake Shiraiwa, Zenjiro Sampei, Kenji Yoshida, Hiroyuki Tsunoda, Reiji Teramoto   +8 more
doaj   +1 more source

AI-based IsAb2.0 for antibody design. [PDF]

Brief Bioinform
Abstract Therapeutic antibody design has garnered widespread attention, highlighting its interdisciplinary importance. Advancements in technology emphasize the critical role of designing nanobodies and humanized antibodies in antibody engineering. However, current experimental methods are costly and time-consuming.
Liang T, Sun ZY, Hines MG, Penrose KJ, Hao Y, Chu X, Mellors JW, Dimitrov DS, Xie XQ, Li W, Feng Z.   +10 more
europepmc   +4 more sources

Rapid affinity optimization of an anti-TREM2 clinical lead antibody by cross-lineage immune repertoire mining

Nature Communications
We describe a process for rapid antibody affinity optimization by repertoire mining to identify clones across B cell clonal lineages based on convergent immune responses where antigen-specific clones with the same heavy (VH) and light chain germline ...
Yi-Chun Hsiao, Heidi Ackerly Wallweber, Robert G. Alberstein, Zhonghua Lin, Changchun Du, Ainhoa Etxeberria, Theint Aung, Yonglei Shang, Dhaya Seshasayee, Franziska Seeger, Andrew M. Watkins, David V. Hansen, Christopher J. Bohlen, Peter L. Hsu, Isidro Hötzel   +14 more
doaj   +1 more source

OptMAVEn--a new framework for the de novo design of antibody variable region models targeting specific antigen epitopes. [PDF]

PLoS ONE, 2014
Antibody-based therapeutics provides novel and efficacious treatments for a number of diseases. Traditional experimental approaches for designing therapeutic antibodies rely on raising antibodies against a target antigen in an immunized animal or ...
Tong Li, Robert J Pantazes, Costas D Maranas   +2 more
doaj   +1 more source

Therapeutic Apheresis in Nigeria: A Multi‐Center Summary of Abstracts From the Inaugural Nigerian Society for Apheresis Scientific Meeting

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Therapeutic apheresis (TA) is an established treatment modality for hematologic, neurologic, and immunologic disorders, yet access remains severely limited in sub‐Saharan Africa. Donor apheresis, including platelet apheresis collection from healthy donors, represents an important complementary modality supporting blood product ...
Nosa Bazuaye, Chimezie Okwuonu, Evelyn Idam, Folasade Adelekan‐Popoola, Shakirat Gold‐Olufadi, Olufunto Olufela Kalejaiye, Abdullateef Ogala, Zinnah Aloziem, Blossom Amamchukwu, Patience Elimia, Mkpoikanabasi Obot‐Obot, Henry Mbakwe, Praises Maduagwuna, Olatunji Akinrodoye, Chiamaka Anyanwu, Benjamin Anyanwu, Adedamola Akinsiku, Oluwatoyin A. Akinsiku, Muzamil O. Hassan, Fatiu A. Arogundade, Olalekan E. Ojo, Homayemem Weli, Jesupelumi Adenihun, Aderemi Adelaja, Ebun Bamgboye, Olalekan Olatise, Ade E. Faponle, Ayoola Odeyemi, Michael Muoka, Stephen Asaolu, Qudrat Busari, Blessing Dawudu, Michael Naiyeju, Rasheed A. Balogun   +33 more
wiley   +1 more source

Boosting antibody responses to Plasmodium falciparum merozoite antigens in children with highly seasonal exposure to infection. [PDF]

, 2010
Longitudinal cohort studies are important to describe the dynamics of naturally acquired antibody response profiles to defined Plasmodium falciparum malaria antigens relative to clinical malaria episodes.
M. PINDER, Dunyo, S, Conway, DJ, O. J. AKPOGHENETA, D. J. CONWAY, Akpogheneta, OJ, Pinder, M, S. DUNYO   +7 more
core   +1 more source