mAbs, 2023 Prolactin (PRL) has recently been demonstrated to elicit female-selective nociceptor sensitization and increase pain-like behaviors in female animals.
Stephanie Maciuba +13 more
doaj +1 more source
Prestige Antibodies™—Monospecific Antibodies Designed for Immunohistochemical Analysis [PDF]
BioTechniques, 2008 Well-characterized antibodies are essential tools for protein studies, global proteomics analysis, as well as for clinical diagnostics. However, although production of antibodies is a well-established process and a large number of antibodies are commercially available through many vendors, specific antibodies still do not exist for the majority of ...
Sara A. Gunnerås +3 more
openaire +7 more sources
Hallucinating structure-conditioned antibody libraries for target-specific binders
Frontiers in Immunology, 2022 Antibodies are widely developed and used as therapeutics to treat cancer, infectious disease, and inflammation. During development, initial leads routinely undergo additional engineering to increase their target affinity.
Sai Pooja Mahajan +5 more
doaj +1 more source
A Novel Human Antibody, HF, against HER2/erb-B2 Obtained by a Computer-Aided Antibody Design Method
Engineering, 2021 Fully human antibodies have minimal immunogenicity and safety profiles. At present, most potential antibody drugs in clinical trials are humanized or fully human.
Chunxia Qiao +10 more
doaj +1 more source
Antibody-drug conjugates for cancer therapy
, 2020 © 2020 by the authors. Licensee MDPI, Basel, Switzerland. Antibody–drug conjugates (ADCs) are novel drugs that exploit the specificity of a monoclonal antibody (mAb) to reach target antigens expressed on cancer cells for the delivery of a potent ...
Sagun Parakh (9493061) +3 more
core +1 more source
AntiFold: improved structure-based antibody design using inverse folding. [PDF]
Bioinform AdvSummary: The design and optimization of antibodies requires an intricate balance across multiple properties. Protein inverse folding models, capable of generating diverse sequences folding into the same structure, are promising tools for maintaining ...
Høie MH +5 more
europepmc +2 more sources
Crystal Structure of an Anti-Ang2 CrossFab Demonstrates Complete Structural and Functional Integrity of the Variable Domain. [PDF]
, 2013 Bispecific antibodies are considered as a promising class of future biotherapeutic molecules. They comprise binding specificities for two different antigens, which may provide additive or synergistic modes of action.
Duerr, Harald +29 more
core +1 more source
Monte Carlo Thompson sampling-guided design for antibody engineering
mAbs, 2023 Antibodies are one of the predominant treatment modalities for various diseases. To improve the characteristics of a lead antibody, such as antigen-binding affinity and stability, we conducted comprehensive substitutions and exhaustively explored their ...
Taro Kakuzaki +8 more
doaj +1 more source
Expression of recombinant multi-coloured fluorescent antibodies in
, 2011 Background Antibody-fluorophore conjugates are invaluable reagents used in contemporary molecular cell biology for imaging, cell sorting and tracking intracellular events.
Durvasula, Ravi V. +26 more
core +1 more source
Stalking influenza by vaccination with pre-fusion headless HA mini-stem. [PDF]
, 2016 Inaccuracies in prediction of circulating viral strain genotypes and the possibility of novel reassortants causing a pandemic outbreak necessitate the development of an anti-influenza vaccine with increased breadth of protection and potential for rapid ...
Carnell, George +24 more
core +1 more source