Expanding the landscape of antibody discovery. [PDF]
Cell Rep MethodsLibrary:library screening technologies hold substantial promise for paired antibody:antigen discovery, but challenges have persisted. In this issue of Cell Reports Methods, Wagner et al. introduce a method that combines antibody-ribosome-mRNA complexes, antigen cell surface display, and single-cell RNA sequencing to successfully screen diverse antibody
Johnson S, DeKosky BJ.
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A platform-agnostic, function first-based antibody discovery strategy using plasmid-free mammalian expression of antibodies [PDF]
mAbs, 2021 Hybridoma technology has been valuable in the development of therapeutic antibodies. More recently, antigen-specific B-cell selection and display technologies are also gaining importance. A major limitation of these approaches used for antibody discovery
Ruijun Zhang +15 more
doaj +2 more sources
Antibodies, repertoires and microdevices in antibody discovery and characterization. [PDF]
Lab ChipEssential in treating numerous diseases, novel therapeutic antibody candidates are needed. This critical review examines recent advances in microdevices and the challenges associated with candidate discovery and characterization.
Schlotheuber LJ, Lüchtefeld I, Eyer K.
europepmc +5 more sources
Technologies for Monoclonal Antibody Discovery and Development. [PDF]
Int J Mol SciMonoclonal antibodies (mAbs) represent one of the most successful classes of biopharmaceuticals, with more than 100 approved for treating oncological, immunological, and infectious diseases. Antibody discovery and development have been driven by diverse methodologies.
Han KH +4 more
europepmc +3 more sources
The Application of Machine Learning on Antibody Discovery and Optimization. [PDF]
MoleculesAntibodies play critical roles in modern medicine, serving as diagnostics and therapeutics for various diseases due to their ability to specifically bind to target antigens. Traditional antibody discovery and optimization methods are time-consuming and resource-intensive, though they have successfully generated antibodies for diagnosing and treating ...
Zheng J, Wang Y, Liang Q, Cui L, Wang L.
europepmc +4 more sources
Versatile and rapid microfluidics-assisted antibody discovery. [PDF]
MAbs, 2021 Recent years have seen unparalleled development of microfluidic applications for antibody discovery in both academic and pharmaceutical research. Microfluidics can support native chain-paired library generation as well as direct screening of antibody secreting cells obtained by rodent immunization or from the human peripheral blood.
Gaa R +5 more
europepmc +5 more sources
Evolution of phage display libraries for therapeutic antibody discovery [PDF]
MAbs, 2023 Zhang Y.
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Animal immunization merges with innovative technologies: A new paradigm shift in antibody discovery [PDF]
MAbs, 2021 Prabakaran Ponraj +2 more
exaly +2 more sources
Dual-target Bridging ELISA for Bispecific Antibodies
Bio-Protocol, 2022 Bispecific antibodies (BsAbs) are typically monoclonal antibody (mAb)–derived molecular entities engineered to bind to two distinct targets, including two antigens or two epitopes on the same antigen.
Min Pei +5 more
doaj +1 more source
Machine-designed biotherapeutics: opportunities, feasibility and advantages of deep learning in computational antibody discovery [PDF]
Briefings in Bioinformatics, 2022 Konrad Krawczyk +2 more
exaly +2 more sources