Results 21 to 30 of about 384,231 (258)

Regulation of antibody-mediated complement-dependent cytotoxicity by modulating the intrinsic affinity and binding valency of IgG for target antigen

mAbs, 2020
Complement-dependent cytotoxicity (CDC) is a potent effector mechanism, engaging both innate and adaptive immunity. Although strategies to improve the CDC activity of antibody therapeutics have primarily focused on enhancing the interaction between the ...
Bo Wang, Chunning Yang, Xiaofang Jin, Qun Du, Herren Wu, William Dall’Acqua, Yariv Mazor   +6 more
doaj   +1 more source

AI/ML combined with next-generation sequencing of VHH immune repertoires enables the rapid identification of de novo humanized and sequence-optimized single domain antibodies: a prospective case study

Frontiers in Molecular Biosciences, 2023
Introduction: In this study, we demonstrate the feasibility of yeast surface display (YSD) and nextgeneration sequencing (NGS) in combination with artificial intelligence and machine learning methods (AI/ML) for the identification of de novo humanized ...
Paul Arras, Paul Arras, Han Byul Yoo, Lukas Pekar, Thomas Clarke, Lukas Friedrich, Christian Schröter, Jennifer Schanz, Jason Tonillo, Vanessa Siegmund, Achim Doerner, Simon Krah, Enrico Guarnera, Stefan Zielonka, Stefan Zielonka, Andreas Evers   +15 more
doaj   +1 more source

mRNA vaccines and hybrid immunity use different B cell germlines against Omicron BA.4 and BA.5

Nature Communications, 2023
Omicron strains of SARS-CoV-2 have displayed high transmissibility and immunological escape to antibody responses derived from natural infection and vaccination.
Emanuele Andreano, Ida Paciello, Giulio Pierleoni, Giuseppe Maccari, Giada Antonelli, Valentina Abbiento, Piero Pileri, Linda Benincasa, Ginevra Giglioli, Giulia Piccini, Concetta De Santi, Claudia Sala, Duccio Medini, Emanuele Montomoli, Piet Maes, Rino Rappuoli   +15 more
doaj   +1 more source

Generation and engineering of potent single domain antibody-based bispecific IL-18 mimetics resistant to IL-18BP decoy receptor inhibition

mAbs, 2023
Here, we generated bispecific antibody (bsAb) derivatives that mimic the function of interleukin (IL)-18 based on single domain antibodies (sdAbs) specific to IL-18 Rα and IL-18 Rβ.
Britta Lipinski, Laura Unmuth, Paul Arras, Stefan Becker, Christina Bauer, Lars Toleikis, Simon Krah, Achim Doerner, Desislava Yanakieva, Ammelie Svea Boje, Katja Klausz, Matthias Peipp, Vanessa Siegmund, Andreas Evers, Harald Kolmar, Lukas Pekar, Stefan Zielonka   +16 more
doaj   +1 more source

Edelman's view on the discovery of antibodies [PDF]

Immunology Letters, 2015
Gerald M. Edelman began working to the structure of antibodies when joined as graduate student the laboratory of Henry Kunkel in 1958 at the "Rockefeller University" in New York, obtaining his doctorate in 1960. Edelman's focus on the structure of antibodies led to the 1972 Nobel Prize in Physiology or Medicine along with Rodney R. Porter.
openaire   +3 more sources

B cell analyses after SARS-CoV-2 mRNA third vaccination reveals a hybrid immunity like antibody response

Nature Communications, 2023
SARS-CoV-2 vaccines and infection induce antibody responses but the evolution of subsequent variants has resulted in the development of escape mutants.
Emanuele Andreano, Ida Paciello, Giulio Pierleoni, Giulia Piccini, Valentina Abbiento, Giada Antonelli, Piero Pileri, Noemi Manganaro, Elisa Pantano, Giuseppe Maccari, Silvia Marchese, Lorena Donnici, Linda Benincasa, Ginevra Giglioli, Margherita Leonardi, Concetta De Santi, Massimiliano Fabbiani, Ilaria Rancan, Mario Tumbarello, Francesca Montagnani, Claudia Sala, Duccio Medini, Raffaele De Francesco, Emanuele Montomoli, Rino Rappuoli   +24 more
doaj   +1 more source

Characterization of MW06, a human monoclonal antibody with cross-neutralization activity against both SARS-CoV-2 and SARS-CoV

mAbs, 2021
The global pandemic of COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in widespread social and economic disruption.
Wen Jiang, Junchao Wang, Shasha Jiao, Chenjian Gu, Wei Xu, Ben Chen, Rongjuan Wang, Huilin Chen, Youhua Xie, An Wang, Gang Li, Dadi Zeng, Jinchao Zhang, Min Zhang, Shuang Wang, Mingzhu Wang, Xun Gui   +16 more
doaj   +1 more source

An integrated mammalian library approach for optimization and enhanced microfluidics-assisted antibody hit discovery

Artificial Cells, Nanomedicine, and Biotechnology, 2023
Recent years have seen the development of a variety of mammalian library approaches for display and secretion mode. Advantages include library approaches for engineering, preservation of precious immune repertoires and their repeated interrogation, as ...
Ramona Gaa, Kavita Kumari, Hannah Melina Mayer, Desislava Yanakieva, Shang-Pu Tsai, Saurabh Joshi, Ralf Guenther, Achim Doerner   +7 more
doaj   +1 more source

Recent Progress in the Discovery and Development of Monoclonal Antibodies against Viral Infections

Biomedicines, 2022
Monoclonal antibodies (mAbs), the new revolutionary class of medications, are fast becoming tools against various diseases thanks to a unique structure and function that allow them to bind highly specific targets or receptors.
Pardis Mokhtary, Zeinab Pourhashem, Akram Abouei Mehrizi, Claudia Sala, Rino Rappuoli   +4 more
doaj   +1 more source

Antibody Representation Learning for Drug Discovery

CoRR, 2022
Therapeutic antibody development has become an increasingly popular approach for drug development. To date, antibody therapeutics are largely developed using large scale experimental screens of antibody libraries containing hundreds of millions of antibody sequences.
Lin Li 0005, Esther Gupta, John Spaeth, Leslie Shing, Tristan Bepler, Rajmonda Sulo Caceres   +5 more
openaire   +2 more sources