Lentiviral gene therapy prevents anti-human acid α-glucosidase antibody formation in murine Pompe disease [PDF]
Molecular Therapy: Methods & Clinical Development, 2022 Enzyme replacement therapy (ERT) is the current standard treatment for Pompe disease, a lysosomal storage disorder caused by deficiency of the lysosomal enzyme acid alpha-glucosidase (GAA).
Qiushi Liang +10 more
doaj +2 more sources
The Use of High Initial Doses of Botulinum Toxin Therapy for Cervical Dystonia Is a Risk Factor for Neutralizing Antibody Formation—A Monocentric Cross-Sectional Pilot Study [PDF]
Medicina, 2022 Background and Objectives: The present study aims to analyze the complex patient/treating physician interaction at onset of botulinum toxin (BoNT) therapy in patients with idiopathic cervical dystonia (CD) and the influence of high initial doses on long ...
Harald Hefter +4 more
doaj +2 more sources
Prevalence and clinical implications of anti-drug antibody formation and serum drug levels among patients with IBD receiving anti-TNF therapy: A cross-sectional study [PDF]
The Saudi Journal of GastroenterologyBackground: The emergence of tumor necrosis factor inhibitors (anti-TNF) has considerably changed the management of inflammatory bowel disease (IBD) in patients who do not respond to traditional therapies.
Ahmed Alghamdi +12 more
doaj +2 more sources
Clinical Consequences of Antibody Formation, Serum Concentrations, and HLA-Cw6 Status in Psoriasis Patients on Ustekinumab. [PDF]
Ther Drug Monit, 2019 Background: Ustekinumab for the treatment of psoriasis is currently administered in a standard dosing regimen. However, some patients tend to benefit from alternative dosing regimens, a step toward personalized medicine.
De Keyser E +9 more
europepmc +3 more sources
Fc Gamma Receptors and Complement Component 3 Facilitate Anti-fVIII Antibody Formation [PDF]
Frontiers in Immunology, 2020 Anti-factor VIII (fVIII) alloantibodies, which can develop in patients with hemophilia A, limit the therapeutic options and increase morbidity and mortality of these patients.
Patricia E. Zerra +15 more
doaj +2 more sources
Impact of biologic induction dose and concomitant drugs on anti-drug antibody formation in a pediatric IBD cohort with high Hispanic representation. [PDF]
JPGN RepGrant K, Pohle J, Tran R, Nattiv R.
europepmc +3 more sources
Comparison of antibody responses after the 1st and 2nd doses of COVID-19 vaccine with those of patients with mild or severe COVID-19 [PDF]
The Korean Journal of Internal Medicine, 2022 Background/Aims Data comparing the antibody responses of different coronavirus disease 2019 (COVID-19) vaccine platforms according to dose with natural severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection-induced antibody responses are ...
Hye Hee Cha +6 more
doaj +1 more source
Anti-SARS-CoV-2 antibody responses in convalescent plasma donors with varying severity of COVID-19 illness [PDF]
Vojnosanitetski Pregled, 2022 Background/Aim. Plasma containing a high titer of anti-SARS-CoV-2 antibodies, donated from individuals who recovered from COVID-19, has the potential to be used as initial therapy for patients who have been infected (passive immunization).
Grujić Jasmina +4 more
doaj +1 more source
The Molecular Mechanisms That Underlie the Immune Biology of Anti-drug Antibody Formation Following Treatment With Monoclonal Antibodies. [PDF]
Front Immunol, 2020 Vaisman-Mentesh A +3 more
europepmc +3 more sources
Comparison of the rapidity of SARS-CoV-2 immune responses between primary and booster vaccination for COVID-19 [PDF]
The Korean Journal of Internal Medicine, 2022 Background/Aims The rapidity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific memory B or T cell response in vaccinated individuals is important for our understanding of immunopathogenesis of coronavirus disease 2019 (COVID-19 ...
Ji Yeun Kim +5 more
doaj +1 more source