The Use of High Initial Doses of Botulinum Toxin Therapy for Cervical Dystonia Is a Risk Factor for Neutralizing Antibody Formation—A Monocentric Cross-Sectional Pilot Study [PDF]
Medicina, 2022 Background and Objectives: The present study aims to analyze the complex patient/treating physician interaction at onset of botulinum toxin (BoNT) therapy in patients with idiopathic cervical dystonia (CD) and the influence of high initial doses on long ...
Harald Hefter +4 more
doaj +2 more sources
The Molecular Mechanisms That Underlie the Immune Biology of Anti-drug Antibody Formation Following Treatment With Monoclonal Antibodies. [PDF]
Front Immunol, 2020 Monoclonal antibodies (mAbs) are a crucial asset for human health and modern medicine, however, the repeated administration of mAbs can be highly immunogenic.
Vaisman-Mentesh A +3 more
europepmc +2 more sources
Circulating T follicular helper cells are a biomarker of humoral alloreactivity and predict donor-specific antibody formation after transplantation. [PDF]
Am J Transplant, 2020 Donor‐specific antibodies (DSAs) contribute to renal allograft loss. However, biomarkers to guide clinical management of DSA posttransplant or detect humoral alloimmune responses before alloantibodies develop are not available.
La Muraglia GM +3 more
europepmc +2 more sources
Lentiviral gene therapy prevents anti-human acid α-glucosidase antibody formation in murine Pompe disease [PDF]
Molecular Therapy: Methods & Clinical Development, 2022 Enzyme replacement therapy (ERT) is the current standard treatment for Pompe disease, a lysosomal storage disorder caused by deficiency of the lysosomal enzyme acid alpha-glucosidase (GAA).
Qiushi Liang +10 more
doaj +2 more sources
Prevalence and clinical implications of anti-drug antibody formation and serum drug levels among patients with IBD receiving anti-TNF therapy: A cross-sectional study [PDF]
The Saudi Journal of GastroenterologyBackground: The emergence of tumor necrosis factor inhibitors (anti-TNF) has considerably changed the management of inflammatory bowel disease (IBD) in patients who do not respond to traditional therapies.
Ahmed Alghamdi +12 more
doaj +2 more sources
TLR9-Activating CpG-B ODN but Not TLR7 Agonists Triggers Antibody Formation to Factor IX in Muscle Gene Transfer. [PDF]
Hum Gene Ther Methods, 2019 Innate immune signals that promote B cell responses in gene transfer are generally ill-defined. In this study, we evaluate the effect of activating endosomal Toll-like receptors 7, 8, and 9 (TLR7, TLR7/8, and TLR9) on antibody formation during muscle ...
Butterfield JSS +7 more
europepmc +2 more sources
THE NATURAL-SELECTION THEORY OF ANTIBODY FORMATION
Proceedings of the National Academy of Sciences of the United States of America, 1955 An immense amount of experimental data related to the problem of antibody formation has accumulated. Theories offering a basic interpretation of these observations have, in contrast, been few.
N. K. Jerne
openalex +2 more sources
Antidrug Antibody Formation in Oncology: Clinical Relevance and Challenges. [PDF]
Oncologist, 2016 : In oncology, an increasing number of targeted anticancer agents and immunotherapies are of biological origin. These biological drugs may trigger immune responses that lead to the formation of antidrug antibodies (ADAs).
van Brummelen EM +4 more
europepmc +2 more sources
Fc Gamma Receptors and Complement Component 3 Facilitate Anti-fVIII Antibody Formation [PDF]
Frontiers in Immunology, 2020 Anti-factor VIII (fVIII) alloantibodies, which can develop in patients with hemophilia A, limit the therapeutic options and increase morbidity and mortality of these patients.
Patricia E. Zerra +15 more
doaj +2 more sources
THE FORMATION AND PROPERTIES OF POLIOVIRUS-NEUTRALIZING ANTIBODY [PDF]
, 1964 Rapid formation of poliovirus-neutralizing antibody was observed in the rabbit. 19S type antibody was detectable 8 to 12 hours following a single intravenous virus injection and the induction period was of the order of 4 to 5 hours or less.
Sven‐Eric Svehag, Benjamin Mandel
semanticscholar +4 more sources