Results 41 to 50 of about 2,253,953 (246)

The role of nonadherence in donor-specific antibodies formation and their effects on kidney transplant function [PDF]

Srpski Arhiv za Celokupno Lekarstvo
Introduction. Antibody-mediated rejection is one of the leading causes of graft loss after kidney transplant. Donor-specific antibodies (DSAs) are recognized as biomarkers of transplant rejection.
Petrović Lada, Mitić Igor, Ćelić Dejan, Popović Milica, Stražmešter-Majstorović Gordana   +4 more
doaj   +1 more source

Race and Household Income Are Associated With Disease Outcomes in Pediatric Patients With Antineutrophil Cytoplasmic Antibody–Associated Vasculitis Hospitalized in the United States

Arthritis Care &Research, EarlyView.
Objective Race and household income impact outcomes in patients with rheumatic conditions; however, their role in pediatric antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV) remains poorly understood. We aimed to evaluate whether race and ethnicity and household income are associated with severe AAV disease and renal outcomes among
Roberto Alejandro Valdovinos, William Daniel Soulsby III, Emily von Scheven   +2 more
wiley   +1 more source

Angiotensin II Type-1 Receptor Antibody in Solid Organ Transplantation – Is It Time to Test?

Transplant International
Angiotensin II type-1 receptor antibody (AT1R-Ab) has been mooted as a potential effector of both acute and chronic antibody mediated rejection (AMR). A growing body of literature on the topic is now coming under scrutiny in the context of the evolving ...
Paul James Patrick Martin, Paul James Patrick Martin, Michelle Willicombe, Michelle Willicombe, Candice Roufosse, Candice Roufosse   +5 more
doaj   +1 more source

ABO-incompatible living donor kidney transplantation failure due to acute blood group antibody-dependent rejection triggered by human parvovirus B19 infection: a case report and literature review

Frontiers in Medicine, 2023
BackgroundWith the improvement of immunosuppressive regimens, the success rate and availability of ABO-incompatible (ABO-i) kidney transplantation (KT) have gradually increased.
Lin-rui Dai, Xiao-hui Wang, Yi-bo Hou, Zhi-yu Zou, Song Chen, Wei-jie Zhang, Sheng Chang   +6 more
doaj   +1 more source

Topically Delivered Treg‐Attracting Microparticle‐Hydrogel Composites Recruit Regulatory T Cells and Limit Cardiac Injury After Severe Ischemia

Advanced Healthcare Materials, EarlyView.
CCL22‐releasing PLGA microparticles (MP) suspended in topically applied hydrogels (HEART) establish a sustained chemokine gradient at the injured myocardium. HEART recruits CCR4+ regulatory T cells, reduces infarct size and graft fibrosis, and improves cardiac function.
Matthew A. Borrelli, Alexis T. Reese, Jordan J. P. Warunek, Betsy Ann Varghese, Canxing Lin, Jeffery J. Baust, Brenda McMahon, Steven R. Little, Hēth R. Turnquist   +8 more
wiley   +1 more source

Pre‐Regenerative Endothelial Cells Empowered by Antler Blood Exosomes Orchestrate Peripheral Nerve Repair

Advanced Science, EarlyView.
The pre‐regenerative vascular niche (PVN) is essential for nerve repair, yet its endothelial blueprint remains unclear. We identified angiogenic ECs (AECs) as the dominant pre‐regenerative subset and found that antler blood–derived exosomes (AB‐EXO) promote repair via IMP3.
Jinsheng Huang, Qiang Chen, Aihua Jin, Xiaoqi Yang, Hui Zhou, Weiquan Gong, Jin Cheng, Jun Dai, Minjin Wang, Meihua Piao, Yuanyi Wang, Nan Zhou   +11 more
wiley   +1 more source

Intimal Arteritis and Microvascular Inflammation Are Associated With Inferior Kidney Graft Outcome, Regardless of Donor-Specific Antibodies

Frontiers in Medicine, 2021
Background: The prognostic role of intimal arteritis of kidney allografts in donor-specific antibody negative (DSA–) antibody-mediated rejection (ABMR) remains unclear.Methods: Seventy-two out of 881 patients who had undergone kidney transplantation from
Marek Novotny, Marek Novotny, Petra Hruba, Martin Kment, Ludek Voska, Katerina Kabrtova, Antonij Slavcev, Ondrej Viklicky, Ondrej Viklicky, Ondrej Viklicky   +9 more
doaj   +1 more source

Cloning and expression of porcine β1,4 N-acetylgalactosaminyl transferase encoding a new xenoreactive antigen [PDF]

, 2014
Xenograft rejection of pigs organs with an engineered mutation in the GGTA-1 gene (GTKO) remains a predominantly antibody mediated process which is directed to a variety of non-Gal protein and carbohydrate antigens.
Kogelberg, H, Du, Z, Stalboerger, P, Byrne, GW, McGregor, CG   +4 more
core  

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Acute Antibody-mediated Rejection Coexisting With T Cell–mediated Rejection in Pediatric ABO-incompatible Transplantation

Transplantation Direct, 2022
Background. The management and outcome of ABO-incompatible (ABO-I) liver transplantation (LT) has been improving over the past few decades. Recently, the introduction of a pathological evaluation of acute antibody-mediated rejection (AMR) for liver ...
Yusuke Yanagi, MD, PhD, Seisuke Sakamoto, MD, PhD, Masaki Yamada, MD, PhD, Koutaro Mimori, MD, Toshimasa Nakao, MD, PhD, Tasuku Kodama, MD, PhD, Hajime Uchida, MD, PhD, Seiichi Shimizu, MD, PhD, Akinari Fukuda, MD, PhD, Noriyuki Nakano, MD, PhD, Chiduko Haga, MD, PhD, Takako Yoshioka, MD, PhD, Mureo Kasahara, MD, PhD   +12 more
doaj   +1 more source