Results 191 to 200 of about 89,614 (291)

Holistic bone developing microenvironment engineered apoptotic extracellular vesicles recapitulate multidimensional developmental signatures in adult and senile bone repair

Interdisciplinary Medicine, EarlyView.
The developing bone was identified as an M2a‐like macrophage driven immune microenvironment with multidimensional developmental signatures. hME‐ApoEVs were successfully fabricated via stimulating the M2a‐like developing microenvironment in vitro and confirmed its recapitulation of developmental features.
Xiaoran Yu, Jieyun Xu, Yuan Zhao, Xinyu Guo, Hongcheng Chen, Junlong Xue, Yong Ao, Linjun Zhang, Xiaomeng Gao, Xueli Mao, Songtao Shi, Zetao Chen   +11 more
wiley   +1 more source

Novel Allele Detection Tool Benchmark and Application With Antibody Repertoire Sequencing Dataset. [PDF]

Front Immunol, 2021
Yang X, Zhu Y, Chen S, Zeng H, Guan J, Wang Q, Lan C, Sun D, Yu X, Zhang Z.   +9 more
europepmc   +1 more source

Tiny carriers, big impact: How Fusobacterium nucleatum extracellular vesicles drive oral diseases and beyond

Interdisciplinary Medicine, EarlyView.
This review explores how Fusobacterium nucleatum extracellular vesicles drive local oral diseases and distal pathologies via sophisticated cross‐compartment cross talk. It highlights the transformative potential of these “tiny carriers” as next‐generation molecular intermediaries for advanced health monitoring and innovative bio‐interventions by ...
Rongyang Ma, Jiahui Huang, Yitong Chen, Haoxuan Wang, Hang Zou, Wanghong Zhao, Zilong Deng   +6 more
wiley   +1 more source

VH-replacement shapes the antibody repertoire by removing the genes of non-functional heavy-chains. [PDF]

EMBO J
White HN, Chovanec P, Biggins L, French EC, Bullen G, Andrews S, Corcoran AE.   +6 more
europepmc   +1 more source

Targeting eIF5A combats breast cancer progression by ClpP‐dependent mitochondrial oxidative stress

Interdisciplinary Medicine, EarlyView.
This study identified the eIF5A‐ClpP axis as a key driver of breast cancer progression. Targeting eIF5A suppresses tumor growth by inducing ClpP‐dependent mitochondrial oxidative stress, revealing a novel therapeutic vulnerability. Abstract Breast cancer (BC) poses a persistent global health challenge, necessitating new therapeutic targets.
Jinmei Zhu, Baoyuan Tang, Bei Xie, Haohua Deng, Haitang Yang, Lei Ma, Ziqing Zhang, Yicheng Ma, Xingyuan Ma, Shuaiyang Wang, Jing Li, Lei Zhao, Wengui Shi, Linjing Li   +13 more
wiley   +1 more source

Persistent IgG1 clones dominate and personalize the plasma antibody repertoire. [PDF]

Sci Adv
van Rijswijck DMH, Bondt A, Raafat D, Holtfreter S, Wietschel KA, van der Lans SPA, Völker U, Bröker BM, Heck AJR.   +8 more
europepmc   +1 more source

THE MAJOR ROLE OF JUNCTIONAL DIVERSITY IN THE HORSE ANTIBODY REPERTOIRE

, 2022
Navas C, Manso T, Martins F, Minto L, Moreira R, Minozzo J, Antunes B, Vale A, McDaniel JR, Ippolito GC, Felicori LF.   +10 more
europepmc   +1 more source

Computational antibody repertoire analysis and design

Antibodies are the core element of human humoral immunity. Advancements in sequencing technologies coupled with a remarkable decline in sequencing cost have been fueling the interest in B cell receptor (BCR) and antibody sequencing.
Bashour, Habib
core  

S100A9 promotes pulmonary arterial hypertension by regulating mitochondria–endoplasmic reticulum interaction‐mediated inflammatory injury of endothelial cells

Interdisciplinary Medicine, EarlyView.
Macrophage‐derived S100 calcium‐binding protein A9 (S100A9) promotes the pathological progression of pulmonary arterial hypertension (PAH). S100A9 upregulates the interaction between signal‐transducing adaptor protein 2 and leucine‐rich repeat kinase 2, thereby regulating mitochondria–endoplasmic reticulum (ER) contact.
Chen Gong, Long Chen, Yiting Zhao, Xiaohe Wang, Qiang Yuan, Xiaofeng Fang, Liuyi Li, Yinbo Xu, Shumei Jiang, Guangwen Xu, Ke Meng, Delong Wang, Kangli Cao, Jianlong Sheng, Liling Guo, Shichun Shen   +15 more
wiley   +1 more source

Intestinal antibody repertoire is altered by diabetes and varies depending on the pathogenesis. [PDF]

Biochem Biophys Rep
Chikazawa M, Minato KI.
europepmc   +1 more source