Results 251 to 260 of about 89,614 (291)
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2008
Symplex is an antibody discovery technology that identifies fully human antigen-specific antibody repertoires directly from plasma cells. The technology utilizes reverse transcription and overlap extension polymerase chain reaction performed on single-cell-sorted plasma cells, whereby the heavy- and light-chain cognate pairing of the antibodies is ...
Per-Johan, Meijer +3 more
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Symplex is an antibody discovery technology that identifies fully human antigen-specific antibody repertoires directly from plasma cells. The technology utilizes reverse transcription and overlap extension polymerase chain reaction performed on single-cell-sorted plasma cells, whereby the heavy- and light-chain cognate pairing of the antibodies is ...
Per-Johan, Meijer +3 more
openaire +2 more sources
Antibody repertoire development in swine
Developmental & Comparative Immunology, 2006Swine belong to the Order Artiodactyla and like mice and humans, express IgM, IgD, IgG, IgE and IgA antibodies but a larger number of IgG subclasses. Like rabbits and chickens, expressed V(H) genes belong to the ancestral V(H)3 family and only 5 comprise >80% of the pre-immune repertoire. Since they use primarily two D(H) segments and have a single J(H)
John E, Butler +3 more
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2015
As in mammals, cartilaginous and teleost fishes possess adaptive immune systems based on antigen recognition by immunoglobulins (Ig), T cell receptors (TCR), and major histocompatibility complex molecules (MHC) I and MHC II molecules. Also it is well established that fish B cells and mammalian B cells share many similarities, including Ig gene ...
Eva, Bengtén, Melanie, Wilson
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As in mammals, cartilaginous and teleost fishes possess adaptive immune systems based on antigen recognition by immunoglobulins (Ig), T cell receptors (TCR), and major histocompatibility complex molecules (MHC) I and MHC II molecules. Also it is well established that fish B cells and mammalian B cells share many similarities, including Ig gene ...
Eva, Bengtén, Melanie, Wilson
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Antibody repertoire development in the sheep
Developmental & Comparative Immunology, 2006The model of immunoglobulin (Ig) repertoire diversification in sheep has evolved dramatically in recent years. A process thought to involve the rearrangement of a very limited number of variable (V), diversity (D) and joining (J) segments followed by intense, antigen (Ag)-independent, somatic hypermutation is now known to be less recombinatorially ...
Craig N, Jenne +2 more
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Development of the Primary Antibody Repertoire
Science, 1987The ability to generate a diverse immune response depends on the somatic assembly of genes that encode the antigen-binding portions of immunoglobulin molecules. In this article, we discuss the mechanism and control of these genomic rearrangement events and how aspects of this process are involved in generating the primary antibody repertoire.
F W, Alt +2 more
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Antibody repertoire development in camelids
Developmental & Comparative Immunology, 2006The humoral immune response of the Camelidae is unique as these animals are the only known mammals that seem to possess functional homodimeric heavy-chain antibodies besides the classical heteromeric antibodies composed of heavy (H) and light (L) chains.
De Genst, Erwin +3 more
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Autoantibodies and the Fetal Antibody Repertoire
International Reviews of Immunology, 1990Developing fetal B cells preferentially rearrange a restricted subset of the encoded antibody gene segments. There are striking structural similarities between elements expressed early in man and in mouse, most evident on comparison of murine VH elements from the VH7183 family to human VH elements of the VH3 family.
J L, Hillson, R M, Perlmutter
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Generating the Antibody Repertoire in Rabbit
1994We describe a model for B cell development and generation of the antibody repertoire in rabbits. In this model, B cells develop early in ontogeny, migrate to GALT, and undergo the first round of diversification by a somatic gene conversion-like process and by somatic mutation.
K L, Knight, M A, Crane
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Analysis of the antibody repertoire of lymphoma patients
Cancer Immunology, Immunotherapy, 2002Cancer testis or cancer germline antigens (CGA) are promising vaccine candidates because they are expressed only in malignant but not in normal tissues, except for germ cells in the testis. Since non-Hodgkin's lymphomas (NHL) express the known CGA at low frequencies, we aimed at increasing the number of CGA with frequent expression in NHL by screening ...
Shaoming, Huang +4 more
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Programmed Development of the Antibody Repertoire
1987Specific immunity in vertebrates requires the generation of a diverse repertoire of antigen-binding structures that are displayed on the surfaces of lymphocytes. These antigen receptors are encoded by a superfamily of gene segments which undergo rearrangements exclusively in lymphoid cells: the V H, D H, and J H segments of antibody heavy chains, V L ...
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