Results 261 to 270 of about 89,614 (291)

Contribution of Receptor Editing to the Antibody Repertoire

Science, 2001
Receptor editing, clonal deletion, and anergy are the mechanisms by which B cells maintain tolerance to self antigens. To determine the extent to which receptor editing shapes the normal antibody repertoire, we generated an immunoglobulin κ polymorphism that facilitates the detection of editing of immunoglobulin light chains in vivo.
R, Casellas, T A, Shih, M, Kleinewietfeld, J, Rakonjac, D, Nemazee, K, Rajewsky, M C, Nussenzweig   +6 more
openaire   +2 more sources

Profiling celiac disease antibody repertoire

Clinical Immunology, 2013
The aim of this study was to dissect the autoantibody response in celiac disease (CD) that remains largely unknown, with the goal of identifying the disease-specific autoantigenic protein pattern or the so called epitome. Sera from CD patients were used to select immunoreactive antigens from a cDNA phage-display library. Candidate genes were identified,
D'Angelo, Sara, Mignone, Flavio, Deantonio, Cecilia, Di Niro, Roberto, Bordoni, Roberta, Marzari, Roberto, De Bellis, Gianluca, Not, Tarcisio, Ferrara, Fortunato, Bradbury, Andrew, Santoro, Claudio, Sblattero, Daniele   +23 more
openaire   +5 more sources

Early Restriction of the Human Antibody Repertoire

Science, 1987
Diversification of the antibody repertoire in mammals results from a series of apparently random somatically propagated gene rearrangement and mutational events. Nevertheless, it is well known that the adult repertoire of antibody specificities is acquired in a developmentally programmed fashion.
H W, Schroeder, J L, Hillson, R M, Perlmutter   +2 more
openaire   +2 more sources

Antibody repertoire development in cartilaginous fish

Developmental & Comparative Immunology, 2006
There are 3 H chain and 3 L chain isotypes in the cartilaginous fish, all encoded by genes in the so-called cluster (VDDJ, VJ) organization. The H chain isotypes IgM and IgNAR, are readily detected at the protein level in most species. The third is readily identified at the protein level in skates (IgR) but only via immunoprecipitation or at the ...
H, Dooley, M F, Flajnik
openaire   +2 more sources

The Human IgE-encoding Transcriptome to Assess Antibody Repertoires and Repertoire Evolution

Journal of Molecular Biology, 2006
Upon encounter with antigen, the B lymphocyte population responds by producing a diverse set of antigen-specific antibodies of various isotypes. The vast size of the responding populations makes it very difficult to study clonal evolution and repertoire composition occurring during these processes in humans. Here, we have explored an approach utilizing
Ulrika, Andréasson, Sabine, Flicker, Malin, Lindstedt, Rudolf, Valenta, Lennart, Greiff, Magnus, Korsgren, Carl A K, Borrebaeck, Mats, Ohlin   +7 more
openaire   +2 more sources

Innovations and trends in antibody repertoire analysis

Current Opinion in Biotechnology
Monoclonal antibodies have revolutionized the treatment of human diseases, which has made them the fastest-growing class of therapeutics, with global sales expected to reach $346.6 billion USD by 2028. Advances in antibody engineering and development have led to the creation of increasingly sophisticated antibody-based therapeutics (e.g.
Douglas R, Townsend, Dalton M, Towers, Jason J, Lavinder, Gregory C, Ippolito   +3 more
openaire   +2 more sources

Monoclonal antibodies – A repertoire of therapeutics

Antibodies are a class of biomolecules armed with extraordinary diversity, unmatched in the biological world by any other class of molecules. This characteristic feature equips antibodies to recognize, bind, and eliminate an infinite number of pathogens/antigens facilitated by their effector functions. The repertoire of natural binding specificities of
openaire   +2 more sources

Large-scale analysis of 2,152 Ig-seq datasets reveals key features of B cell biology and the antibody repertoire

Cell Reports, 2021
Xiujia Yang, Yanfang Zhang, Chunhong Lan   +2 more
exaly  

The Dynamic Nature of the Antibody Repertoire

Immunological Reviews, 1988
C, Berek, C, Milstein
openaire   +2 more sources

Development of the Antibody Repertoire in Rabbits

Annals of the New York Academy of Sciences, 1995
K L, Knight, M A, Crane
openaire   +2 more sources