Results 261 to 270 of about 1,017,137 (336)

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Preclinical and Clinical Performance of the Efoora Test, a Rapid Test for Detection of Human Immunodeficiency Virus-Specific Antibodies

, 2005
Max Q. Arens, Linda M. Mundy, Daniel Amsterdam, J. Tom Barrett, D Bigg, David A. Bruckner, Bruce A. Hanna, Harry E. Prince, Timothy Purington, Todd Hanna, Ross G. Hewitt, Carolyn Kalinka, Thomas Koppes, S. S. Maxwell, Ardis Moe, Mehmet Ziya Doymaz, Melinda D. Poulter, Maryam Saber-Tehrani, Lorenzo Simard, Donna Wilkins-Carmody, John Vidaver, Cheryl Berger, Alan H. Davis, Mortimer T. Alzona   +23 more
openalex   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Specific antibody deficiency in children with recurrent respiratory infections: a controlled study with follow-up

, 2012
Olli Ruuskanen, Anu Nurkka, Mika Helminen, M Viljanen, Helena Käyhty, Leena Kainulainen   +5 more
openalex   +1 more source

The effect of salubrinal on the endoplasmic reticulum stress pathway in heat‐stressed spermatogonial cells in vitro

FEBS Open Bio, EarlyView.
This study investigates the protective role of salubrinal against heat‐induced endoplasmic reticulum (ER) stress in mouse spermatogenic cells (GC1 and GC2). By modulating the ER stress pathway, salubrinal alleviates cellular stress and supports spermatogenic cell survival, suggesting its potential as a therapeutic candidate for heat‐related infertility.
Suna Karadeniz Saygili, Mustafa Oztatlici, Mahmut Kemal Ozbilgin   +2 more
wiley   +1 more source

Recent Advances in Lateral Flow Immunoassay for Rapid Diagnosis of Viral Diseases. [PDF]

Transbound Emerg Dis
Ren Q, Wang Y, Ma H, Xie J, Jin J, Tian R, Yu H, Gao X, Chen N.   +8 more
europepmc   +1 more source

Sendai virus-specific T-cell clones: induction of cytolytic T cells by an anti-idiotypic antibody directed against a helper T-cell clone.

, 1984
Hildegund C.J. Ertl, Robert W. Finberg
openalex   +2 more sources

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Editorial: Antibody can get it right: confronting problems of antibody specificity and irreproducibility.

Mol Endocrinol, 2014
Schonbrunn A.
europepmc   +1 more source