Results 101 to 110 of about 552,206 (313)
Molecular Oncology, EarlyView.LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David +12 more
wiley +1 more source
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
Cell-Based Anticancer Drug Delivery Systems
, 2016 Most explored approaches to developing cell-based drug delivery systems (DDSs) are encapsulation of the drug into the cells, cell surface modification, genetic modification of cells to secrete desired therapeutic proteins, and generating new biosynthetic
Bosnakovski, Darko +5 more
core +2 more sources
A Database of Drug Repurposing Clinical Trials in Oncology
Frontiers in Pharmacology, 2021 Pan Pantziarka +3 more
doaj +1 more source
Prospect of Anticancer Therapy [PDF]
Cancer Research and Treatment, 2004 Despite advances in the early detection, active treatment and focus on survivorship of cancer patients, the unfortunate reality is that many will still die of cancer. Cancer is the most common cause of death in Korea, with approximately one fourth of all deaths, 59,000, in 2001, and is increasing annually.
openaire +2 more sources
The multifaceted roles of lysosomes in cancer
Molecular Oncology, EarlyView.Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley +1 more source
Azatyrosinamides: Novel RAS-related anticancer agents
, 2013 [[abstract]]Background: We previously reported on the design and synthesis of novel azatyrosinamide derivatives selective for ras-transformed NIH3T3 cells and with improved toxicity over azatyrosine. This study was aimed at investigating the mechanism of
Wang, CL;Lee, O;Huang, CF;Li, EIC;Teng, CM;Pan, SL;Lian, JF;Chang, FS;Liou, JP;Wang, HP
core
Vascular normalization confers an endothelial immune suppressive gene expression profile
Molecular Oncology, EarlyView.We compare the immunoregulatory gene expression profiles of healthy endothelial cells or endothelial cells from tumors having a normalized endothelium (low leakage) with that of wild‐type tumors (high leakage) and observe that the wild‐type tumor endothelium exhibits immunostimulatory properties.
Liqun He, Michael Welsh
wiley +1 more source
Frontiers in OncologyBackground/aimIvermectin is emerging as a potential anticancer agent. Recombinant methioninase (rMETase) targets methionine addiction of cancer and shows synergistic efficacy when combined with cancer-chemotherapy drugs. In the present study, we compared
Jinsoo Kim +13 more
doaj +1 more source
, 2019 A mild amination protocol of N-heteroaryl alkyl ethers with various amines is described. This transformation is achieved by utilizing simple and readily available base as promoter via C–O bond cleavage, offering a new amination strategy to access ...
Yi-Xin Qu (6843827) +17 more
core +1 more source