Results 101 to 110 of about 10,530,811 (405)
In vitro anticancer activity and oxidative molecular damage by cannabidiol administered alone and in combination with epirubicin [PDF]
, 2021 Margarita Zhelyazkova +3 more
openalex +1 more source
New sulfurated derivatives of cinnamic acids and rosmaricine as inhibitors of STAT3 and NF-kappa B transcription factors [PDF]
, 2017 A set of new sulfurated drug hybrids, mainly derived from caffeic and ferulic acids and rosmaricine, has been synthesized and their ability to inhibit both STAT3 and NF-kappa B transcription factors have been evaluated.
Asai, Akira +7 more
core +2 more sources
Oncology Report, 2019 Gallic acid (3,4,5‑trihydroxybenzoic acid; GA), a plant‑derived natural phenolic compound, has been reported to prevent the development and progression of various types of cancers.
Tingxiu Zhang +9 more
semanticscholar +1 more source
Anticancer activity of osmium metalla-rectangles [PDF]
Dalton Transactions, 2010 A series of cationic metalla-rectangles of the general formula [(p-cymene)(4)Os(4)(OO[intersection]OO)(2)(N[intersection]N)(2)](4+) have been obtained in methanol from the dinuclear arene osmium precursors [(p-cymene)(2)Os(2)(OO[intersection]OO)(2)Cl(2)] (OO[intersection]OO = 2,5-dioxydo-1,4-benzoquinonato (dhbq), 2,5-dichloro-1,4-benzoquinonato (dcbq))
Barry, Nicolas P.E. +3 more
openaire +2 more sources
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Anticancer activity of benzoxazole derivative (2015 onwards): a review
Future Journal of Pharmaceutical Sciences, 2020 According to the report published recently by the World Health Organization, the number of cancer cases in the world will increase to 22 million by 2030.
Tanay Ghoshal, Tarun M. Patel
semanticscholar +1 more source
Anticancer Activity of Natural Compounds [PDF]
Asian Pacific Journal of Cancer Prevention, 2021 Abdul Q, Khan, Shahab, Uddin
openaire +2 more sources
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Tamoxifen-like metallocifens target thioredoxin system determining mitochondrial impairment leading to apoptosis in Jurkat cells [PDF]
, 2017 Tamoxifen-like metallocifens (TLMs) of the group-8 metals (Fe, Ru, and Os) show strong anti-proliferative activity on cancer cell lines resistant to apoptosis, owing to their unique redox properties. In contrast, the thioredoxin system, which is involved
Alberto Bindoli +9 more
core +3 more sources
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source