Results 191 to 200 of about 5,890,540 (213)

A Glucose Metabolism‐Modulatory Nanobiohybrid Vaccine Platform Promotes Anti‐Tumor Immunity by Orchestrating Autophagy‐Dependent Cross‐Presentation and H2S‐Enhanced NLRP3 Inflammasome Signaling

Advanced Science, EarlyView.
A nanobiohybrid vaccine was designed by constructing a hydrogen‐bonded organic framework coencapsulated with glucose oxidase (GOx) and tumor antigens. This nanobiohybrid vaccine executed a GOx‐catalyzed enzyme reaction that disrupted glucose metabolism and induced redox imbalance in dendritic cells, leading to autophagy‐dependent antigen cross ...
Weidong Wang, Yimin Gong, Jianing Li, Tianze Wu, Mingli Deng, Yannan Yang   +5 more
wiley   +1 more source

Rewiring Pyroptosis to Potentiate Cancer Immunotherapy via a Gasdermin D Agonist Bypassing Caspase‐3

Advanced Science, EarlyView.
This work introduces a small‐molecule agonist, DIBDO, that bypasses Casp‐3 to directly trigger GSDMD‐mediated pyroptosis in tumors. Activated by glutathione, DIBDO generates singlet oxygen and molecular iodine, blocking Casp‐3 pathways and inducing immunogenic cell death.
Dan Zhao, Lingling Zhang, Yue Wen, Lianghui Cheng, Sidan Tian, Fanling Meng, Liang Luo   +6 more
wiley   +1 more source

A Supramolecular Thermal Switch for Precision Pyroptosis via Host−Guest Recognition and Electrostatic Interactions

Advanced Science, EarlyView.
A supramolecular pyroptotic thermal switch encapsulates I3− within β‐cyclodextrin (β‐CD) and undergoes CaCO3 mineralization. Upon lysosomal acidification, CaCO3 is degraded, releasing Ca2+ and I3−. Concurrently, BODIPY activation converts I3− into I2, inducing oxidative stress and Ca2+ overload, which together trigger caspase‐3/GSDME‐mediated ...
Dan Wu, Jie Zhou, Yibin Cao, Kunmin Ping, Borui Zhao, Yanrong Yang, Chunyang Yu, Xinyang Yu, Shaolong Qi   +8 more
wiley   +1 more source

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Structure–Activity Relationship of Benzofuran Derivatives with Potential Anticancer Activity

Cancers, 2022
Basem Al-Omari, Lara Alzyoud
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Artemisinin-derived hybrids and their anticancer activity

European Journal of Medicinal Chemistry, 2020
Feng Gao, Jiaqi Xiao
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Pharmacogenetics and pharmacogenomics of anticancer agents

Ca-A Cancer Journal for Clinicians, 2009
Mark Ratain, R Stephanie Huang
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Indole Alkaloids with Potential Anticancer Activity

Current Topics in Medicinal Chemistry, 2020
Zhi Xu
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Determination of the Anticipated Therapeutic Effect of an Anticancer Drug in an Individual Patient

Ca-A Cancer Journal for Clinicians, 1964
R N Grant
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Tetrazole hybrids with potential anticancer activity

European Journal of Medicinal Chemistry, 2019
Zhi Xu
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Effects of molecular weight and hydrolysis conditions on anticancer activity of fucoidans from sporophyll of Undaria pinnatifida

International Journal of Biological Macromolecules, 2008
Sangguan You, Il-Shik Shin, Donghwa Chung   +2 more
exaly