Results 271 to 280 of about 531,591 (309)

Enzyme-Catalyzed Activation of Anticancer Prodrugs

Pharmacological Reviews, 2004
The rationale fo the development of prodrugs relies upon delivery of higher concentrations of a drug to target cells compared to administration of the drug itself. In the last decades, numerous prodrugs that are enzymatically activated into anti-cancer agents have been developed.
Rooseboom, M., Commandeur, J.N.M., Vermeulen, N.P.E.   +2 more
openaire   +3 more sources

HIGHLY ACTIVE ANTICANCER CURCUMIN ANALOGUES

2007
Curcumin, a compound in the human food supply, represents a near-perfect starting point for drug discovery. Consequently, a number of research groups have taken the natural product as a starting point to prepare and biologically evaluate a wide variety of curcumin analogues.
Cara A, Mosley, Dennis C, Liotta, James P, Snyder   +2 more
openaire   +2 more sources

Advances in Chalcones with Anticancer Activities

Recent Patents on Anti-Cancer Drug Discovery, 2014
Chalcones are naturally occurring compounds exhibiting broad spectrum biological activities including anticancer activity through multiple mechanisms. Literature on anticancer chalcones highlights the employment of three pronged strategies, namely; structural manipulation of both aryl rings, replacement of aryl rings with heteroaryl scaffolds ...
Chandrabose, Karthikeyan, Narayana S H Narayana, Moorthy, Sakthivel, Ramasamy, Uma, Vanam, Elangovan, Manivannan, Devarajan, Karunagaran, Piyush, Trivedi   +6 more
openaire   +2 more sources

Anticancer activity of novel indenopyridine derivatives

Archives of Pharmacal Research, 2012
Eighteen new 4-[2-amino-3-cyano-5-oxo-4-substitutedaryl-4H-indeno[1,2-b]pyridin-1-(5H)-yl]benzenesulfonamide derivatives 6a-q were synthesized via a reaction of aromatic aldehydes, enaminone 3 and malononitrile in one-pot reaction. Also, compounds 6a-q were obtained, via another route by reaction of enaminone 3 with arylidenemalononitriles 4a-q.
Mostafa M, Ghorab, Mansour S, Al-Said
openaire   +2 more sources

Anticancer activity of salicin and fenofibrate

Naunyn-Schmiedeberg's Archives of Pharmacology, 2017
Cancer refers to a disorder of cell proliferation that leads to tumor production. Cancer is usually treated by surgery, chemotherapeutic drugs, and radiation. Despite the presence of many anticancer drugs, cancer is still an uncontrolled disease and is a major cause of death worldwide.
Marwa, Sabaa, Hassan M, ELFayoumi, Shimaa, Elshazly, Mahmoud, Youns, Waleed, Barakat   +4 more
openaire   +2 more sources

Anticancer Activities of Tumor-killing Nanorobots

Trends in Biotechnology, 2019
Pharmaceutical uses of cancer therapeutics, such as intravenous thrombin to elicit blood coagulation, have been hampered by lack of tumor specificity. Based on rapid progress in DNA origami-based machines capable of transporting molecular payloads, DNA nanorobots have been constructed to specifically deliver therapeutic agents into tumor vessels.
Suping Li, Qiao Jiang, Baoquan Ding, Guangjun Nie   +3 more
openaire   +3 more sources

Trees with Anticancer Activities

2017
Many trees are known to possess important anticancer compounds which include flavonoids and other phenolic compounds, glucosinolates, phytosterols, phytoestrogens, tannins, and protease inhibitors which interrupt with the mitotic activities of abnormal cells.
openaire   +1 more source

Hypoxia-activated anticancer drugs

Expert Opinion on Therapeutic Patents, 2005
Whilst hypoxia is increasingly recognised as a limiting factor in the successful treatment of solid tumours by conventional radiotherapy and chemotherapy, its unique occurrence in such tumours is also viewed as offering the possibility of selective chemotherapy.
openaire   +1 more source

Anticancer Activity of Flavonoids

Flavonoids like the synthetic flavone, flavopiridol; the soy isoflavonoid, genistein; the tea catechin epigallocatechin gallate; or the common dietary flavonol, quercetin, are emerging as prospective anticancer drug candidates and some of them have already entered in clinical trials. A positive correlation between flavonoids-rich diet and lower risk of
Abul Kalam Azad, Mohamad Dayoob, Fatema Tuz Zohera   +2 more
openaire   +1 more source

[Anticancer activity of flavonoids].

Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 2013
On the basis of previous in vitro, in vivo and epidemiological studies was found that flavonoids among their many biological and pharmacological properties have a great anticancer potential. High intake of foods rich in these compounds, mainly vegetables and fruits is associated with a low rate of cancer in humans.
Monika, Majewska-Wierzbicka, Hanna, Czeczot   +1 more
openaire   +1 more source