Results 261 to 270 of about 6,504,034 (299)

Anticancer activity of salicin and fenofibrate

Naunyn-Schmiedeberg's Archives of Pharmacology, 2017
Cancer refers to a disorder of cell proliferation that leads to tumor production. Cancer is usually treated by surgery, chemotherapeutic drugs, and radiation. Despite the presence of many anticancer drugs, cancer is still an uncontrolled disease and is a major cause of death worldwide.
Marwa, Sabaa, Hassan M, ELFayoumi, Shimaa, Elshazly, Mahmoud, Youns, Waleed, Barakat   +4 more
openaire   +2 more sources

The cryptophycins: Their synthesis and anticancer activity

Medicinal Research Reviews, 2002
AbstractThe cryptophycins are a unique family of 16‐membered macrolide antimitotic agents isolated from the cyanobacteria Nostoc sp. Their molecular target is tubulin protein wherein they are the most potent known stabilizers of microtubule dynamics and depolymerize microtubules at higher concentrations.
MariJean, Eggen, Gunda I, Georg
openaire   +2 more sources

Fungal metabolites with anticancer activity

Nat. Prod. Rep., 2014
The review discusses the reported sources, structures and biochemical studies aimed at the exploitation of the anticancer potential associated with fungal secondary metabolites.
EVIDENTE, ANTONIO, Alexander Kornienko, CIMMINO, ALESSIO, ANDOLFI, ANNA, Florence Lefranc, V?ronique Mathieu, Robert Kiss   +6 more
openaire   +4 more sources

Trisindoline synthesis and anticancer activity

Biochemical and Biophysical Research Communications, 2008
Expression of a Rhodococcus-derived oxygenase gene in Escherichia coli yielded indigo metabolites with cytotoxic activity against cancer cells. Bioactivity-guided fractionation of these indigo metabolites led to the isolation of trisindoline as the agent responsible for the observed in vitro cytotoxic activity against cancer cells.
Miyoun, Yoo, Sang-Un, Choi, Ki Young, Choi, Gyu Hwan, Yon, Jong-Chan, Chae, Dockyu, Kim, Gerben J, Zylstra, Eungbin, Kim   +7 more
openaire   +2 more sources

Synthesis and anticancer activity of thiosemicarbazones

Bioorganic & Medicinal Chemistry Letters, 2006
Twenty-six thiosemicarbazones (III-1-III-26) were synthesized via three steps starting from hydrazine hydrate and carbon disulfide. The testing of anticancer activity of these compounds in vitro against P-388, A-549, and SGC-7901 shows that compounds III-15 and III-16 possess a higher inhibitory ability for P-388 and SGC-7901.
Wei-xiao, Hu, Wei, Zhou, Chun-nian, Xia, Xi, Wen   +3 more
openaire   +2 more sources

Enzyme-Catalyzed Activation of Anticancer Prodrugs

Pharmacological Reviews, 2004
The rationale fo the development of prodrugs relies upon delivery of higher concentrations of a drug to target cells compared to administration of the drug itself. In the last decades, numerous prodrugs that are enzymatically activated into anti-cancer agents have been developed.
Rooseboom, M., Commandeur, J.N.M., Vermeulen, N.P.E.   +2 more
openaire   +3 more sources

NO donors with anticancer activity

Expert Opinion on Therapeutic Patents, 2002
Nitric oxide (NO) radicals, endogenously produced from L-arginine or supplied by NO-releasing donors, are involved in numerous physiological and pathological processes. Although there has been rapid growth in NO research, cancer research still remains in its infancy.
Adam J Janczuk, Qiang Jia, Ming Xian, Zhong Wen, Peng George Wang, Tingwei Cai   +5 more
openaire   +1 more source

Trees with Anticancer Activities

2017
Many trees are known to possess important anticancer compounds which include flavonoids and other phenolic compounds, glucosinolates, phytosterols, phytoestrogens, tannins, and protease inhibitors which interrupt with the mitotic activities of abnormal cells.
openaire   +1 more source

The Broadening Scope of Oral Mucositis and Oral Ulcerative Mucosal Toxicities of Anticancer Therapies

Ca-A Cancer Journal for Clinicians, 2022
Stephen Sonis, Noam Yarom, Michal Kuten-Shorrer   +2 more
exaly  

Anticancer Activity of Flavonoids

Flavonoids like the synthetic flavone, flavopiridol; the soy isoflavonoid, genistein; the tea catechin epigallocatechin gallate; or the common dietary flavonol, quercetin, are emerging as prospective anticancer drug candidates and some of them have already entered in clinical trials. A positive correlation between flavonoids-rich diet and lower risk of
Abul Kalam Azad, Mohamad Dayoob, Fatema Tuz Zohera   +2 more
openaire   +1 more source