Results 241 to 250 of about 6,504,034 (299)

Solvent dependent synthesis of silver nanoparticles using <i>Morus rubra</i>: correlating physicochemical properties with antimicrobial and anticancer activity. [PDF]

RSC Adv
Nadaf AH, Mohammed AA, Mahmoud HQ, Aherkar VV, Bhairungi SB, Ovhal RM, Ubale PA.   +6 more
europepmc   +1 more source

YTHDC1 Orchestrates Glucose and Glutamate Rewiring to Overcome Lethal Metabolic Stress in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Lai et al. find that m6A reader YTHDC1 is specifically overexpressed in triple‐negative breast cancer (TNBC) and orchestrates glucose and glutamine metabolism in an m6A‐dependent manner to confer robust adaptability to lethal metabolic stress. Leveraging YTHDC1 knockdown‐induced metabolic vulnerability, an ATF4 mRNA‐targeted nanotherapy is developed to
Zheng‐Hao Lai, Yi Wang, Na‐Na Li, Ling Zeng, Renzhong Liu, Xue Li, Cheukfai Li, Xin‐Yu Ma, Wenkui Fu, Yingsen Tang, Jinjin Chen, Ning Liao, Man‐Li Luo   +12 more
wiley   +1 more source

Novel glutaminase-free l-asparaginase from <i>Leuconostoc mesenteroides</i> BN1: biochemical properties, molecular dynamics, and anticancer activity. [PDF]

RSC Adv
Charoenwongpaiboon T, Wangpaiboon K, Srichompoo Y, Septham P, Klaihmon P, Khampang S, Issaragrisil S, Lorthongpanich C.   +7 more
europepmc   +1 more source

Glucose and Glutamine Deprivation Promotes Breast Cancer Lung Metastasis via BRD4‐Dependent Enhancer Activation

Advanced Science, EarlyView.
To model a nutrient‐restricted tumor microenvironment, breast cancer cells were adapted to low glucose and glutamine levels. In the adapted cells, BRD4‐driven enhancer activation increases pro‐invasive EDN1 expression, facilitated by ATF3/c‐JUN and reinforced by enhancer RNA.
Poshan Yugal Bhattarai, Arathy Vasukutty, Yujin Na, Sung‐Chul Lim, Hong Seok Choi   +4 more
wiley   +1 more source

Phytochemical Analysis Using LC-MS/MS and Anticancer Activity of Asphodelus tenuifolius Roots: Cell Cycle Arrest, Apoptosis, and In Silico Insights. [PDF]

Chem Biodivers
Bouchouka RL, Larit F, Kabouche Z, Debiossat M, Riou L, Ghezzi C, León F, Kabouche A.   +7 more
europepmc   +1 more source

Macrophage Trogocytosis of Tumor Cells Drives the Immunosuppression of Tumor Microenvironment

Advanced Science, EarlyView.
Trogocytosis efficiency varies significantly among different tumor cells and is inversely related to their cortical stiffness; this efficiency dictates the extent of immunosuppression via upregulation of CXCL5 and Arg‐1, ultimately driving CD8+T cell exhaustion and tumor escape.
Chao Liang, Jiaqi He, Wan‐Ru Zhuang, Yao Lei, Yanru Jiang, Xianbin Ma, Pan Liu, Zhujun Jiang, Yongheng Li, Hai‐Yan Xie   +9 more
wiley   +1 more source

Plant- and Algae-Derived Compounds Enhance the Anticancer Activity of Doxorubicin in Colorectal Cancer Cell Lines. [PDF]

Molecules
Ramos-Silva JA, Lara-Hernández G, Fuentes-Garibay JA, Pérez-Soto E, Flores-Berrios EP, Avilés-Arnaut H.   +5 more
europepmc   +1 more source

Metal-dependent Structure, Solution Properties, and Redox-Mediated Anticancer Activity of Rhodium(III) and Iridium(III) Half-Sandwich Phenanthroline-Sulfonamide Complexes. [PDF]

Inorg Chem
Żukowska N, Kowalik M, Maciejewska N, Alfuth J, Dębowski D, Kazimierczuk K, Makowski M.   +6 more
europepmc   +1 more source