Results 21 to 30 of about 464,460 (389)

Anticoagulants and Osteoporosis [PDF]

International Journal of Molecular Sciences, 2019
Anticoagulant agents are widely used in the treatment of thromboembolic events and in stroke prevention. Data about their effects on bone tissue are in some cases limited or inconsistent (oral anti-vitamin K agents), and in others are sufficiently strong (heparins) to suggest caution in their use in subjects at risk of osteoporosis.
Signorelli S. S., Scuto S., Marino E., Giusti M., Xourafa A., Gaudio A.   +5 more
openaire   +3 more sources

Synthesis and in Vitro and in Vivo Anticoagulant and Antiplatelet Activities of Amidino- and Non-Amidinobenzamides

Molecules, 2016
Three amidino- and ten non-amidinobenzamides were synthesized as 3-aminobenzoic acid scaffold-based anticoagulant and antiplatelet compounds. The anticoagulant activities of thirteen synthesized compounds 1–13, and 2b and 3b as prodrugs were preliminary ...
Soo Hyun Lee, Wonhwa Lee, Jong-Sup Bae, Eunsook Ma   +3 more
doaj   +1 more source

Shear viscosity and nonlinear behaviour of whole blood under large amplitude oscillatory shear [PDF]

, 2013
We investigated experimentally the rheological behavior of whole human blood subjected to large amplitude oscillatory shear under strain control to assess its nonlinear viscoelastic response.
Alves, M.A., Carneiro, J., Cerejo, A., Oliveira, Monica, Pinho, F.T., Sousa, P.C., Vaz, R.   +6 more
core   +1 more source

Risk Stratification Using the CHA2DS2‐VASc Score in Takotsubo Syndrome: Data From the Takotsubo Italian Network

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundThe CHA2DS2‐VASc score predicts stroke in patients with atrial fibrillation and has been reported to have a prognostic role even in acute coronary syndrome patients.
Guido Parodi, Fernando Scudiero, Rodolfo Citro, Angelo Silverio, Benedetta Bellandi, Concetta Zito, Francesco Antonini‐Canterin, Fausto Rigo, Chiara Zocchi, Eduardo Bossone, Jorge Salerno‐Uriarte, Federico Piscione, Carlo Di Mario   +12 more
doaj   +1 more source

Anticoagulation in the Elderly [PDF]

Pharmaceuticals, 2010
Management of anticoagulation in elderly patients represents a particularly challenging issue. Indeed, this patient population is at high thromboembolic risk, but also at high hemorrhagic risk. Assessment of the benefit-risk balance of anticoagulation is the key point when decisions are made about introducing and/or continuing such treatments in the ...
Robert-Ebadi, Helia, Righini, Marc Philip   +1 more
openaire   +3 more sources

Anticoagulant and signaling functions of antithrombin

Journal of Thrombosis and Haemostasis, 2020
Antithrombin (AT) is a major plasma glycoprotein of the serpin superfamily that regulates the proteolytic activity of the procoagulant proteases of both intrinsic and extrinsic pathways.
A. Rezaie, H. Giri
semanticscholar   +1 more source

Prior Direct Oral Anticoagulant Therapy is Related to Small Infarct Volume and No Major Artery Occlusion in Patients With Stroke and Non‐Valvular Atrial Fibrillation

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
Background The aims of the present study were to investigate the relationships between prior direct oral anticoagulant (DOAC) therapy and infarct volume and the site of arterial occlusion in patients with acute ischemic stroke and non‐valvular atrial ...
Yuki Sakamoto, Seiji Okubo, Tetsuro Sekine, Chikako Nito, Satoshi Suda, Noriko Matsumoto, Yasuhiro Nishiyama, Junya Aoki, Takashi Shimoyama, Takuya Kanamaru, Kentaro Suzuki, Masahiro Mishina, Kazumi Kimura   +12 more
doaj   +1 more source

Anticoagulants [PDF]

Journal of Pharmacy and Pharmacology, 1949
Abstract The processes that underly the clotting of blood are still far from adequately understood, in spite of the many facts uncovered by generations of patient investigators. The classical scheme associated with the name of Morawitz1, although neither complete nor universally accepted, is still useful as a summary of the main events ...
openaire   +3 more sources

Prevalence, Characteristics, and Outcomes of Valvular Heart Disease in Patients With Atrial Fibrillation: Insights From the ORBIT‐AF (Outcomes Registry for Better Informed Treatment for Atrial Fibrillation)

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundThe presence of valvular heart disease (VHD) may affect the risk of stroke and mortality in patients with atrial fibrillation (AF). Community‐based estimates of prevalence and outcomes of specific forms of VHD in patients with AF are lacking ...
Kevin L. Thomas, Larry R. Jackson, Peter Shrader, Jack Ansell, Gregg C. Fonarow, Bernard Gersh, Peter R. Kowey, Kenneth W. Mahaffey, Daniel E. Singer, Laine Thomas, Jonathan P. Piccini, Eric D. Peterson   +11 more
doaj   +1 more source

Mycolactone-dependent depletion of endothelial cell thrombomodulin is strongly associated with fibrin deposition in Buruli ulcer lesions [PDF]

, 2015
A well-known histopathological feature of diseased skin in Buruli ulcer (BU) is coagulative necrosis caused by the Mycobacterium ulcerans macrolide exotoxin mycolactone.
A Andreoli, AA Pahlevan, AC Chany, Alexander Stainer, AM Healy, B Isermann, B Roche, Belinda S. Hall, BS Hall, C Bozzo, C Simpson, CA Moxon, Charles T. Esmon, CJ d'Adhemar, CT Esmon, CT Esmon, CT Esmon, D Mehta, D Schutte, D Yeboah-Manu, DH Connor, DJ Stearns-Kurosawa, DS Walsh, E Coutanceau, E Coutanceau, E Torrado, E Zavattaro, F Song, FS Sarfo, FS Sarfo, G Archipoff, G Kunz, Gerd Pluschke, HC Huang, Hua-Lin Wu, I Maruyama, J Ahnstrom, JJ Peterson, JM Kanga, Josefin Ahnström, Joy Ogbechi, K Fukudome, Katherine Bodman-Smith, KM George, KM George, KY Hui, L Guenin-Mace, LO Mosnier, M Chu, Marcel A. Behr, Marie-Thérèse Ruf, Moritz Vogel, MT Ruf, MT Ruf, MT Ruf, MT Ruf, MT Silva, MW Boehme, PJ Converse, PP Nawroth, Rachel E. Simmonds, RE Simmonds, RE Simmonds, RO Phillips, RW Merritt, S Adusumilli, S Navarro, S Vaiyapuri, S Vaiyapuri, TJ Raife, TL Cheng, TL Le, VW van Hinsbergh, WA Nienhuis, X Ye, YY Hsu   +75 more
core   +5 more sources