Results 21 to 30 of about 354,756 (297)

Ischemic Stroke despite Oral Anticoagulant Therapy in Patients with Atrial Fibrillation

Annals of Neurology, 2020
It is not known whether patients with atrial fibrillation (AF) with ischemic stroke despite oral anticoagulant therapy are at increased risk for further recurrent strokes or how ongoing secondary prevention should be managed.
D. Seiffge, G. M. De Marchis, M. Koga, M. Paciaroni, D. Wilson, M. Cappellari, Kosmas Macha, G. Tsivgoulis, G. Ambler, S. Arihiro, L. Bonati, B. Bonetti, B. Kallmünzer, K. Muir, P. Bovi, H. Gensicke, M. Inoue, S. Schwab, S. Yaghi, Martin M. Brown, P. Lyrer, Masahito Takagi, Monica Acciarrese, H. Jager, A. Polymeris, K. Toyoda, M. Venti, C. Traenka, H. Yamagami, A. Alberti, S. Yoshimura, V. Caso, S. Engelter, D. Werring   +33 more
semanticscholar   +1 more source

Different Anticoagulant Regimens, Mortality, and Bleeding in Hospitalized Patients with COVID-19: A Systematic Review and an Updated Meta-Analysis

Seminars in Thrombosis and Hemostasis, 2021
We conducted a systematic review and a meta-analysis to assess the association of anticoagulants and their dosage with in-hospital all-cause mortality in COVID-19 patients.
R. Parisi, S. Costanzo, A. Di Castelnuovo, G. de Gaetano, M. Donati, L. Iacoviello   +5 more
semanticscholar   +1 more source

Consensus‐based clinical recommendations and research priorities for anticoagulant thromboprophylaxis in children hospitalized for COVID‐19–related illness

Journal of Thrombosis and Haemostasis, 2020
Observational studies indicate that children hospitalized with COVID‐19‐related illness, like adults, are at increased risk for venous thromboembolism (VTE).
N. Goldenberg, A. Sochet, M. Albisetti, T. Biss, M. Bonduel, J. Jaffray, G. MacLaren, P. Monagle, S. O’Brien, L. Raffini, S. Revel-Vilk, N. Sirachainan, Suzan Williams, A. Zia, C. Male   +14 more
semanticscholar   +1 more source

Anticoagulant and signaling functions of antithrombin

Journal of Thrombosis and Haemostasis, 2020
Antithrombin (AT) is a major plasma glycoprotein of the serpin superfamily that regulates the proteolytic activity of the procoagulant proteases of both intrinsic and extrinsic pathways.
A. Rezaie, H. Giri
semanticscholar   +1 more source

Perioperative Management of Patients With Atrial Fibrillation Receiving a Direct Oral Anticoagulant.

JAMA Internal Medicine, 2019
Importance Patients with atrial fibrillation (AF) who use a direct oral anticoagulant (DOAC) and request elective surgery or procedure present a common clinical situation yet perioperative management is uncertain. Objective To investigate the safety of
J. Douketis, A. Spyropoulos, J. Duncan, M. Carrier, G. Le Gal, A. Tafur, T. Vanassche, P. Verhamme, S. Shivakumar, P. Gross, Agnes Y. Y. Lee, E. Yeo, S. Solymoss, J. Kassis, G. Le Templier, S. Kowalski, M. Blostein, Vinay Shah, Elizabeth Mackay, Cynthia Wu, N. Clark, S. Bates, F. Spencer, E. Arnaoutoglou, M. Coppens, D. Arnold, J. Caprini, Na Li, K. Moffat, S. Syed, S. Schulman   +30 more
semanticscholar   +1 more source

The Anticoagulant and Nonanticoagulant Properties of Heparin

Thrombosis and Haemostasis, 2020
Heparins represent one of the most frequently used pharmacotherapeutics. Discovered around 1926, routine clinical anticoagulant use of heparin was initiated only after the publication of several seminal papers in the early 1970s by the group of Kakkar ...
D. Beurskens, Joram P. Huckriede, R. Schrijver, H. Hemker, C. Reutelingsperger, G. Nicolaes   +5 more
semanticscholar   +1 more source

Trends in anticoagulant prescribing: a review of local policies in English primary care

BMC Health Services Research, 2020
Background Oral anticoagulants are prescribed for stroke prophylaxis in patients with atrial fibrillation, which is the most common heart arrhythmia worldwide. The vitamin K antagonist (VKA) warfarin is a long-established anticoagulant.
Katherine H. Ho, M. van Hove, G. Leng
semanticscholar   +1 more source

Long term risk of symptomatic recurrent venous thromboembolism after discontinuation of anticoagulant treatment for first unprovoked venous thromboembolism event: systematic review and meta-analysis

British medical journal, 2019
Objectives To determine the rate of a first recurrent venous thromboembolism (VTE) event after discontinuation of anticoagulant treatment in patients with a first episode of unprovoked VTE, and the cumulative incidence for recurrent VTE up to 10 years ...
F. Khan, Alvi Rahman, M. Carrier, C. Kearon, J. Weitz, S. Schulman, F. Couturaud, S. Eichinger, P. Kyrle, C. Becattini, G. Agnelli, T. Brighton, A. Lensing, M. Prins, E. Sabri, B. Hutton, L. Pinède, M. Cushman, G. Palareti, G. Wells, P. Prandoni, H. Büller, M. Rodger   +22 more
semanticscholar   +1 more source

Anticoagulant interventions in hospitalized patients with COVID‐19: A scoping review of randomized controlled trials and call for international collaboration

Journal of Thrombosis and Haemostasis, 2020
Coronavirus disease (COVID‐19) is associated with a high incidence of thrombosis and mortality despite standard anticoagulant thromboprophylaxis. There is equipoise regarding the optimal dose of anticoagulant intervention in hospitalized patients with ...
T. Tritschler, M. Mathieu, L. Skeith, M. Rodger, S. Middeldorp, T. Brighton, P. Sandset, S. Kahn, D. Angus, M. Blondon, M. Bonten, M. Cattaneo, M. Cushman, L. Derde, M. Desancho, J. Diehl, E. Goligher, B. Jilma, P. Jüni, P. Lawler, M. Marietta, J. Marshall, C. McArthur, C. H. Miranda, T. Mirault, N. Morici, Usha Perepu, C. Schörgenhofer, M. Sholzberg, A. Spyropoulos, S. Webb, R. Zarychanski, S. Zuily, G. Le Gal   +33 more
semanticscholar   +1 more source

An Albumin-Oligonucleotide Assembly for Potential Combinatorial Drug Delivery and Half-Life Extension Applications

Molecular Therapy: Nucleic Acids, 2017
The long blood circulatory property of human serum albumin, due to engagement with the cellular recycling neonatal Fc receptor (FcRn), is an attractive drug half-life extension enabling technology. This work describes a novel site-specific albumin double-
Matthias Kuhlmann, Jonas B.R. Hamming, Anders Voldum, Georgia Tsakiridou, Maja T. Larsen, Julie S. Schmøkel, Emil Sohn, Konrad Bienk, David Schaffert, Esben S. Sørensen, Jesper Wengel, Daniel M. Dupont, Kenneth A. Howard   +12 more
doaj   +1 more source