Results 51 to 60 of about 47,218 (298)
Timing of Anticonvulsant Administration in Status Epilepticus
Pediatric Neurology Briefs, 2015 Investigators from the Pediatric Status Epilepticus Research Group studied the time elapsed from onset of pediatric convulsive status epilepticus (SE) to administration of antiepileptic drugs (AED).
Juan A Piantino
doaj +1 more source
European Psychiatry, 2022 Introduction The anticonvulsant m-Cl-BHM is promising for the pathogenetically directed thrapy does not cause negative effects. Objectives Investigation of the effect of m-Сl-BHM on “immunochemical homeostasis” in rats with experimental alcoholism ...
Т. Shushpanova +12 more
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American Journal of Medical Genetics Part A, EarlyView.ABSTRACT SATB2‐associated syndrome (SAS) is characterized by intellectual disability, neurodevelopmental disorders, cleft palate, and dental abnormalities. SAS is caused by variants in the special AT‐rich sequence‐binding protein 2 (SATB2), which encodes a transcription factor containing two CUT domains and a homeobox (HOX) domain.
Nao Ukita +5 more
wiley +1 more source
Treating Epilepsy with Natural Products: Nonsense or Possibility?
Pharmaceuticals, 2023 Epilepsy is a neurological disease characterized by recurrent seizures that can lead to uncontrollable muscle twitching, changes in sensitivity to sensory perceptions, and disorders of consciousness.
Milan Malaník +5 more
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Developmental Toxicity Study of DL-4-Hydroxy-4-Phenylhexanamide (DL-HEPB) in Rats
Life, 2023 Antiepileptic drugs affect embryonic development when administered during pregnancy, generating severe alterations, such as as cleft lip, spina bifida, heart abnormalities, or neuronal alterations.
José Melesio Cristóbal-Luna +5 more
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Enaminone‐Based Push–Pull Chromophores: Synthesis, Optical Properties, and Computational Insights
Asian Journal of Organic Chemistry, Accepted Article.Chromophores incorporating enaminone units were efficiently synthesized using click‐type [2+2] cycloaddition‐retroelectrocyclization (CA‐RE) reactions. The preparation of electron‐rich alkynes necessary for these reactions initiated with the synthesis of alkynones via Sonogashira cross‐coupling, followed by nucleophilic conjugate addition to yield the ...
Mehmet Mart +2 more
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Animal models of cisplatin‐induced neuropathic pain
Animal Models and Experimental Medicine, EarlyView.This article illustrates the modeling process of a cisplatin‐induced neuropathic pain model in rats or mice. Multiple modeling tests are required for rats or mice before, during, and after modeling. The appropriate injection method, dose, and modeling method are selected, and multiple assays are chosen for evaluation and comparison.
Ningxin Li +9 more
wiley +1 more source
Marine Drugs, 2019 Thirty-four new benzo[d]thiazol derivatives 2a−2i, 3a−3r, and 4a−4g were synthesized and investigated for their potential antidepressant and anticonvulsant effects.
Qinghao Jin +3 more
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Whole genome sequencing identifies putative associations between genomic polymorphisms and clinical response to the antiepileptic drug levetiracetam [PDF]
arXiv, 2019 In the context of pharmacogenomics, whole genome sequencing provides a powerful approach for identifying correlations between response variability to specific drugs and genomic polymorphisms in a population, in an unbiased manner. In this study, we employed whole genome sequencing of DNA samples from patients showing extreme response (n=72) and non ...
arxiv
Annals of Neurology, EarlyView.Objective Gain‐of‐function (GoF) variants in KCNT1 encoding for potassium channels are associated with different epilepsy phenotypes, including epilepsy of infancy with migrating focal seizures (EIMFS), other early infantile developmental and epileptic encephalopathies, and focal epilepsy.
Marina Trivisano +13 more
wiley +1 more source