Results 51 to 60 of about 285,368 (185)

Neuroactive steroids in depression and anxiety disorders: Clinical studies [PDF]

, 2006
Certain neuroactive steroids modulate ligand-gated ion channels via non-genomic mechanisms. Especially 3 alpha-reduced pregnane steroids are potent positive allosteric modulators of the gamma-aminobutyric acid type A (GABA(A)) receptor.
Akwa Y, Baghai TC, Baker ER, Barrett-Connor E, Bicikova M, Bitran D, Bloch M, Brambilla F, Brambilla F, Brambilla F, Cornelius Schüle, Crawley JN, Dalton K, Daniela Eser, Dennerstein L, Dong E, Elena Romeo, Eser D, Evans RM, Fabian TJ, Freeman E, Freeman EW, Friess E, George MS, Goodyer IM, Guidotti A, Heydari B, Heydary B, Kita A, Koszycki D, Lawrie TA, Maayan R, Magill PJ, Majewska MD, Majewska MD, Majewska MD, Matsumoto K, Meieran SE, Melchior CL, Melchior CL, Mensah-Nyagan AG, Mienville JM, Monnet FP, Padberg F, Papadopoulos V, Paul SM, Purdy RH, Rainer Rupprecht, Reddy DS, Reddy DS, Reddy DS, Rodgers RJ, Romeo E, Rupprecht R, Rupprecht R, Schmidt PJ, Schule C, Schule C, Semeniuk T, Serra M, Serra M, Strohle A, Strohle A, Strohle A, Strous RD, Takebayashi M, Thomas C. Baghai, Tollefson GD, Trauger JW, Urani A, Uzunov DP, Uzunova V, Uzunova V, Uzunova V, Vanselow W, Wieland S, Wolkowitz OM, Wolkowitz OM, Wu FS, Zwanzger P   +79 more
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The Antidepressant-Like Effects of a Clinically Relevant Dose of Ketamine Are Accompanied by Biphasic Alterations in Working Memory in the Wistar Kyoto Rat Model of Depression

Frontiers in Psychiatry, 2021
Major depressive disorder (MDD) is the leading cause of disability worldwide. The majority of antidepressant drugs require several weeks or months of treatment to demonstrate efficacy and a subset of patients are resistant to such interventions. Ketamine
Conor W. McDonnell, Fionn Dunphy-Doherty, Jennifer Rouine, Massimiliano Bianchi, Neil Upton, Ewa Sokolowska, Jack A. Prenderville   +6 more
doaj   +1 more source

Experimental pharmacological research regarding some new quinazolin-4-ones derivatives [PDF]

, 2019
A series of new compounds with quinazolin-4-one structure, synthesized by the Pharmaceutical Chemistry Department of the Faculty of Pharmacy of the University of Medicine and Pharmacy “Carol Davila” Bucharest, was studied.
Bratu, Mihaela, Chiriță, Cornel, Chiriță, Ileana C, Limban, Carmen, Marineci, Cristina D, Negreș, Simona, Nuță, Diana C, Zbârcea, Cristina E, Ștefănescu, Emil   +8 more
core   +1 more source

Emulating a randomized clinical trial with real-world data to evaluate the effect of antidepressant use in PTSD patients with high suicide risk

Frontiers in Psychiatry
IntroductionPost-Traumatic Stress Disorder (PTSD) entails behavioral changes with increased risk of suicide, and there is no consensus on the preferred antidepressants for treatment of those PTSD patients who are at elevated risk for suicide.MethodsWe ...
Oshin Miranda, Xiguang Qi, M. Daniel Brannock, Ryan Whitworth, Thomas Kosten, Neal David Ryan, Gretchen L. Haas, Gretchen L. Haas, Gretchen L. Haas, Levent Kirisci, LiRong Wang   +10 more
doaj   +1 more source

Potential antidepressant effects of a dietary supplement from the chlorella and lion's mane mushroom complex in aged SAMP8 mice

Frontiers in Nutrition, 2022
Since the 1990s, the prevalence of mental illnesses, such as depression, has been increasing annually and has become a major burden on society. Due to the many side effects of antidepressant drugs, the development of a complementary therapy from natural ...
Ming-Yu Chou, Jou-Hsuan Ho, Mao-Jung Huang, Ying-Ju Chen, Mei-Due Yang, Liang-Hung Lin, Ching-Hsin Chi, Chin-Hsi Yeh, Tsui-Ying Tsao, Jian-Kai Tzeng, Rachel Jui-cheng Hsu, Ping-Hsiu Huang, Wen-Chien Lu, Po-Hsien Li, Ming-Fu Wang, Ming-Fu Wang   +15 more
doaj   +1 more source

Antidepressant use associated with increased risk of hip fracture in the older population [PDF]

, 2017
Commentary on: Torvinen-Kiiskinen S, Tolppanen AM, Koponen M, et al. Antidepressant use and risk of hip fractures among community-dwelling persons with and without Alzheimer's disease. Int J Geriatr Psychiatry 2017. doi: 10.1002/gps.4667.
Kennedy, Michelle
core   +1 more source

Association of inflammation cytokines with cognitive function in first-episode major depressive disorder

Frontiers in Psychiatry
ObjectiveAbnormal cognitive functioning is a core symptom of Major Depressive Disorder (MDD) and is strongly correlated with MDD prognosis. Current studies suggest that the occurrence of MDD may be related to oxidative stress-induced inflammation ...
Yan Qing Xi, Yan Qing Xi, Yan Qing Xi, Zong Qi Wang, Zong Qi Wang, Zong Qi Wang, Guo Juan Li, Guo Juan Li, Guo Juan Li, Zhuo Qun Hao, Zhuo Qun Hao, Zhuo Qun Hao, Jia Hui Nie, Jin Xiang Li, Yu Ting Tan, Xiao Dong Hu, Xiao Dong Hu, Gen Wei Wang, Sha Liu, Sha Liu, Yan Fang Wang, Yan Fang Wang, Yan Fang Wang   +22 more
doaj   +1 more source

Cholinergic regulation of mood: from basic and clinical studies to emerging therapeutics. [PDF]

, 2019
Mood disorders are highly prevalent and are the leading cause of disability worldwide. The neurobiological mechanisms underlying depression remain poorly understood, although theories regarding dysfunction within various neurotransmitter systems have ...
Dulawa, Stephanie C, Janowsky, David S
core  

The utility of PET imaging in depression

Frontiers in Psychiatry
This educational review article aims to discuss growing evidence from PET studies in the diagnosis and treatment of depression. PET has been used in depression to explore the neurotransmitters involved, the alterations in neuroreceptors, non ...
Shashi B. Singh, Atit Tiwari, Maanya R. Katta, Riju Kafle, Cyrus Ayubcha, Cyrus Ayubcha, Krishna H. Patel, Yash Bhattarai, Thomas J. Werner, Abass Alavi, Mona-Elisabeth Revheim, Mona-Elisabeth Revheim   +11 more
doaj   +1 more source

Glycogen synthase kinase-3 in the etiology and treatment of mood disorders

Frontiers in Molecular Neuroscience, 2011
The mood disorders major depressive disorder and bipolar disorder are prevalent, are inadequately treated, and little is known about their etiologies.
Richard Scott Jope
doaj   +1 more source