Realising the therapeutic potential of neuroactive steroid modulators of the GABAA receptor [PDF]
, 2020 In the 1980s particular endogenous metabolites of progesterone and of deoxycorticosterone were revealed to be potent, efficacious, positive allosteric modulators (PAMs) of the GABAA receptor (GABAAR).
Belelli, Delia +3 more
core +1 more source
Initial severity and antidepressant efficacy for anxiety disorders, obsessive-compulsive disorder, and posttraumatic stress disorder:An individual patient data meta-analysis [PDF]
, 2018 Background: It has been suggested that antidepressant benefits are smaller for mild than severe depression. Because antidepressants are also used for anxiety disorders, obsessive-compulsive disorder (OCD), and posttraumatic stress disorder (PTSD), we ...
Burgerhof, Johannes G M +3 more
core +9 more sources
The potential use of melatonin for preventing cisplatin ototoxicity : an insight for a clinical approach [PDF]
, 2014 Cisplatin, one of the most effective and potent anticancer drugs, is used in the treatment of a wide variety of both pediatric and adult malignancies.
Araujo, Juliana Gusmão de +3 more
core +3 more sources
Effectiveness of antidepressants: an evidence myth constructed from a thousand randomized trials? [PDF]
, 2008 Antidepressants, in particular newer agents, are among the most widely prescribed medications worldwide with annual sales of billions of dollars. The introduction of these agents in the market has passed through seemingly strict regulatory control.
John PA Ioannidis
core +1 more source
Depression: Current treatments with low cost strategies [PDF]
, 2014 Depression has profound social, economic and personal consequences for the affected individual, and it shows no signs of abating in the general population. There are several treatment modalities available for this debilitating illness, however, effective
Appleby J +11 more
core +1 more source
Antidepressants versus placebo for depression in primary care [PDF]
, 2009 Background Concern has been expressed about the relevance of secondary care studies to primary care patients specifically about the effectiveness of antidepressant medication.
Arroll, Bruce +7 more
core +3 more sources
Transgenerational inheritance of paternal neurobehavioral phenotypes: stress, addiction, ageing and metabolism [PDF]
, 2015 Epigenetic modulation is found to get involved in multiple neurobehavioral processes. It is believed that different types of environmental stimuli could alter the epigenome of the whole brain or related neural circuits, subsequently contributing to the ...
Arias-Carrión, Oscar +9 more
core +1 more source
The multiple hit model of infantile and epileptic spasms: The 2025 update
Epilepsia Open, EarlyView.Abstract Objective Infantile and epileptic spasms syndrome (IESS) is a developmental and epileptic encephalopathy manifesting with epileptic spasms and poor neurodevelopmental outcomes. There is an urgent need for the development of more effective and tolerated therapies.
Aristea S. Galanopoulou +6 more
wiley +1 more source
Evaluation of Potential Hormonal Activities of Ashwagandha (Withania somnifera)
Phytotherapy Research, EarlyView.ABSTRACT Ashwagandha is a widely used herb in traditional medicine systems, particularly Ayurveda. Despite its extensive tradition, growing concerns regarding its potential endocrinological effects have prompted scientific scrutiny. This review systematically evaluates the current preclinical, clinical, and case study evidence concerning AS's effects ...
Günter Vollmer, Thomas Brendler
wiley +1 more source
Class effect of pharmacotherapy in bipolar disorder: fact or misbelief? [PDF]
, 2011 BACKGROUND: Anecdotal reports suggests that most clinicians treat medications as belonging to a class with regard to all therapeutic indications; this means that the whole 'class' of drugs is considered to possesses a specific therapeutic action.
Eduard Vieta +3 more
core +3 more sources