Results 71 to 80 of about 60,520 (265)

Antidepressant-induced sexual dysfunction: A naturalistic study comparing sexual dysfunction among patients taking escitalopram, desvenlafaxine, and mirtazapine

Annals of Indian Psychiatry, 2021
Background: Antidepressant drugs are frequently associated with sexual dysfunction. Sexual side effects affect the patients' quality of life and in the long term and can lead to noncompliance and relapse.
Raj Kiran Donthu, J Shivanand Manohar, Ravish Thunga   +2 more
doaj   +1 more source

Antidepressant-like Effects of Neuropeptide SF (NPSF) [PDF]

World Journal of Research and Review (WJRR) ISSN:2455-3956, Volume-4, Issue-5, May 2017 Pages 26-30, 2020
Neuropeptide SF (NPSF) is a member of RFamide neuropeptides that play diverse roles in central nervous system. Little is know about the effects of NPSF on brain functions. Antidepressant-like effect of NPSF was studied in modified mice FST. NPSF showed the antidepressant-like effects by decreasing the immobility time and increasing the climbing and ...
arxiv  

Antidepressant effects of a single dose of ayahuasca in patients with recurrent depression: a preliminary report [PDF]

, 2015
Objectives: Ayahuasca (AYA), a natural psychedelic brew prepared from Amazonian plants and rich in dimethyltryptamine (DMT) and harmine, causes effects of subjective well-being and may therefore have antidepressant actions.
Crippa, José A., de Araujo, Draulio B., de Osório, Flàvia L., dos Santos, Rafael G., Hallak, Jaime E. C, Macedo, Ligia R., Maia-De-Oliveira, Joao P., Riba, Jordi, Sanches, Rafael F., Universitat Autònoma de Barcelona, Wichert-Ana, Lauro   +10 more
core   +6 more sources

Pharmacological Treatment of Neuropsychiatric Symptoms in Huntington's Disease: A Systematic Review

Movement Disorders Clinical Practice, EarlyView.
ABSTRACT Background Studies focusing on the treatment of neuropsychiatric symptoms (NPS) in Huntington's disease (HD) are scarce and show a wide variation in design, outcome measures and methodological quality. The effectiveness of pharmacological treatment of NPS in HD has not been systematically reviewed so far.
Ruben L. Andriessen, Mayke Oosterloo, Jory Molema, Maud M.J. Daemen, David E.J. Linden, Albert F.G. Leentjens   +5 more
wiley   +1 more source

An efficient multiple imputation algorithm for control-based and delta-adjusted pattern mixture models using SAS [PDF]

Statistics in Biopharmaceutical research 2016, 2016
In clinical trials, mixed effects models for repeated measures (MMRM) and pattern mixture models (PMM) are often used to analyze longitudinal continuous outcomes. We describe a simple missing data imputation algorithm for the MMRM that can be easily implemented in standard statistical software packages such as SAS PROC MI.
arxiv   +1 more source

Perillaldehyde Improves Parkinson‐Like Deficits by Targeting G3BP Mediated Stress Granule Assembly in Preclinical Models

Advanced Science, Volume 12, Issue 14, April 10, 2025.
This study uncovers that stress granules (SGs) are involved in the pathogenesis of Parkinson's disease (PD). Perillaldehyde (PAE) can improve Parkinson‐like deficits in preclinical models by directly binding to G3BP and instigating liquid–liquid phase separation (LLPS) of G3BP.
Minglv Fang, Lingling Luo, Youjia Chen, Ying Liu, Yingxuan Yan, Fei Wang, Yan Zou, Huanhu Zhu, Xiaojun Wu, Zhigang Jin, Cheng Huang, Yu Zhang, Shengjie Fan   +12 more
wiley   +1 more source

Trends in Brazilian market of antidepressants: A five-year dataset analysis

Frontiers in Pharmacology, 2022
Introduction: Depression is an emotional disorder associated with morbidities and disabilities worldwide. The growing use of antidepressants is a concern for health managers because there are still unanswered questions on the effectiveness and safety of ...
Rogério Hoefler, Rogério Hoefler, Taís Freire Galvão, Inês Ribeiro-Vaz, Inês Ribeiro-Vaz, Marcus Tolentino Silva   +5 more
doaj   +1 more source

Estimating Individualized Treatment Rules in Longitudinal Studies with Covariate-Driven Observation Times [PDF]

arXiv, 2022
The sequential treatment decisions made by physicians to treat chronic diseases are formalized in the statistical literature as dynamic treatment regimes. To date, methods for dynamic treatment regimes have been developed under the assumption that observation times, i.e., treatment and outcome monitoring times, are determined by study investigators ...
arxiv  

Post-stroke depression modulation and in vivo antioxidant activity of gallic acid and its synthetic derivatives in a murine model system [PDF]

, 2016
Gallic acid (3,4,5-trihydroxybenzoic acid, GA) is a plant secondary metabolite, which shows antioxidant activity and is commonly found in many plant-based foods and beverages.
Antoni Sureda, Arianna Di Lorenzo, Maria Daglia, Misra, Roger, Sarkaki, Sedigheh Khanjani, Seyed Nabavi, Seyed Nabavi, Solomon Habtemariam   +9 more
core   +2 more sources

Chronic stress induces behavioural changes through increased kynurenic acid by downregulation of kynurenine‐3‐monooxygenase with microglial decline

British Journal of Pharmacology, Volume 182, Issue 7, Page 1466-1486, April 2025.
Background and Purpose Alterations in tryptophan‐kynurenine (TRP‐KYN) pathway are implicated in major depressive disorder (MDD). α7 nicotinic acetylcholine (α7nACh) receptor regulates the hypothalamic–pituitary–adrenal (HPA) axis. We have shown that deficiency of kynurenine 3‐monooxygenase (KMO) induces depression‐like behaviour via kynurenic acid ...
Masaya Hasegawa, Kazuo Kunisawa, Bolati Wulaer, Hisayoshi Kubota, Hitomi Kurahashi, Takatoshi Sakata, Honomi Ando, Suwako Fujigaki, Hidetsugu Fujigaki, Yasuko Yamamoto, Taku Nagai, Kuniaki Saito, Toshitaka Nabeshima, Akihiro Mouri   +13 more
wiley   +1 more source