Results 41 to 50 of about 99,190 (260)

Alpha-Glucosidase Inhibition and Hypoglycemic Activities of Sweitenia mahagoni Seed Extract

Hayati Journal of Biosciences, 2015
Inhibition of α-glucosidase and hypoglycemic activity are two effects commonly used to identify bioactive compounds with potential to treat diabetes.
TUTIK WRESDIYATI, SITI SA'DIAH, ADI WINARTO, VENNY FEBRIYANI   +3 more
doaj   +1 more source

Exploring potential antidiabetic and anti-inflammatory flavonoids from Euphorbia humifusa with an integrated strategy

Frontiers in Pharmacology, 2022
E. humifusa Willd, a monoecious annual plant, native to Eastern Asia, has been traditionally attributed to the treatment and prevention of miscellaneous diseases, including diabetes mellitus and its associated complications.
Tojofaniry Fabien Rakotondrabe, Tojofaniry Fabien Rakotondrabe, Tojofaniry Fabien Rakotondrabe, Minxia Fan, Minxia Fan, Minxia Fan, Mingquan Guo, Mingquan Guo, Mingquan Guo, Mingquan Guo   +9 more
doaj   +1 more source

Reversing Temozolomide Resistance in Glioblastoma Based on Cuproptosis‐Mediated Positive Feedback Loop

Advanced Science, EarlyView.
To effectively reverse TMZ resistance, this work proposes a cuproptosis‐mediated positive feedback loop that integrates mitochondrial dysfunction, ATP depletion, AMPK‐p53 signaling, and glycolytic inhibition, ultimately amplifying cell death. This cuproptosis‐mediated feedback loop simultaneously disrupts multiple resistance pathways in GBM, including ...
Wenjie Feng, Rui Yang, Chang Weng, Chen Li, Wanrui Shi, Yang Chen, Yang Yang, Yi Liu, Pengfei Ge, Hao Zhang   +9 more
wiley   +1 more source

The Antidiabetic Potential of Alpha‐Mangostin: A Review of Preclinical and Clinical Evidence

AgriFood: Journal of Agricultural Products for Food, EarlyView.
Alpha‐mangostin is a compound from the pericarp of Garcinia mangostana. The antidiabetic effects of alpha‐mangostin include enhancing insulin secretion, improving glucose uptake through GLUT receptor upregulation, reducing oxidative stress and inflammation, promoting wound healing, reducing HbA1C, reducing HOMA‐IR index, and decreased mRNA expressions ...
Oliver Dean John, Nur Damia Iwani Zulkiflee, Siti Raihanah Shafie, Ramlah George, Melonney Patrick   +4 more
wiley   +1 more source

Antidiabetic Activities of 80% Methanol Extract and Solvent Fractions of Verbascum Sinaiticum Benth (Scrophulariaceae) Leaves in Mice

Journal of Experimental Pharmacology, 2023
Beyene Dereje,1 Aschalew Nardos,2 Jemal Abdela,3 Lidet Terefe,2 Melese Arega,4 Terfo Mikre Yilma,5 Tilahun Tesfaye6 1Department of Pharmacology, School of Medicine, College of Medicine and Health Science, Dire Dawa University, Dire Dawa, Ethiopia ...
Dereje B, Nardos A, Abdela J, Terefe L, Arega M, Yilma TM, Tesfaye T   +6 more
doaj  

In silico study of the active compounds in bitter melon (Momordica charantia L) as antidiabetic medication [PDF]

Pharmaciana, 2018
Antidiabetic are many drugs available in the market, but most medications have side effects that are relatively high and cause toxicity, so it needs tobe develoved search of new drug compounds were more potent drugs with side effects as low.
Ruswanto Ruswanto, Richa Mardianingrum, Tresna Lestari, Tita Nofianti, Lilis Tuslinah, Dudi Nurmalik   +5 more
doaj   +1 more source

Very Long‐Term Outcomes of Laparoscopic Adjustable Gastric Banding in a Japanese Cohort: A Single‐Center 15‐Year Follow‐Up Study

Annals of Gastroenterological Surgery, EarlyView.
Long‐term outcomes of laparoscopic adjustable gastric banding (LAGB) in Japan were retrospectively evaluated in 28 patients with up to 15 years of follow‐up. LAGB achieved sustained long‐term weight reduction in selected patients; however, recurrence of metabolic comorbidities increased during extended follow‐up.
Yuichi Endo, Hiroomi Takayama, Wataru Miyoshino, Shun Nakamura, Yuiko Nagasawa, Masahiro Kawamura, Yoko Kawano, Takashi Masuda, Teijiro Hirashita, Yoshinori Ozeki, Takayuki Masaki, Hirotaka Shibata, Masafumi Inomata   +12 more
wiley   +1 more source

Isolation of Bioactive Compounds from Calicotome villosa Stems

Molecules, 2018
A phenylethanoid, two steroids, a flavone glucoside and a chalcone have been isolated for the first time from the stems of Calicotome villosa together with a previously isolated flavone glucoside.
Josiane Alhage, Hoda Elbitar, Samir Taha, Jean-Paul Guegan, Zeina Dassouki, Thomas Vives, Thierry Benvegnu   +6 more
doaj   +1 more source

Pharmacogenetics of Antidiabetic Drugs

, 2018
Pharmacogenetic studies of antidiabetic drugs have so far focused largely on response to metformin, which is the first-line therapy for treatment of type 2 diabetes (T2D). The first studies of metformin pharmacogenetics were focused on candidate genes that were implicated in metformin pharmacokinetics and transport.
Srinivasan, Shylaja, Giacomini, Kathleen, Yee, Sook Wah   +2 more
openaire   +4 more sources

Strategies for inducing diabetes in laboratory animals: Advances from chemical, surgical, immunologic, dietary, and genetic approaches

Animal Models and Experimental Medicine, EarlyView.
This review summarizes the principal experimental approaches used to induce diabetes in animal models. Strategies include chemical agents (streptozotocin, alloxan, dithizone, gold thioglucose), dietary interventions (high‐fat and high‐sugar diets), surgical methods (total or partial pancreatectomy), genetic models (db/db, ob/ob, Goto‐Kakizaki [GK ...
Milad Faraji, Maedeh Faraji, Nasrin Kazemipour   +2 more
wiley   +1 more source