Results 41 to 50 of about 134,759 (289)

Antidiabetic (α-amylase and α-glucosidase) and anti-obesity (lipase) inhibitory activities of edible cassava (Manihot esculenta Crantz) as measured by in vitro gastrointestinal digestion: effects of phenolics and harvested time

open access: yesInternational Journal of Food Properties, 2022
Edible cassava leaves (Manihot esculenta) were consumed as vegetables for their bioactive compounds, however the effect of harvesting time on these bioactive compounds and their antidiabetic and anti-obesity inhibitory activities were scarcely reported ...
Alphonse Laya   +2 more
doaj   +1 more source

Rheumatoid Arthritis and Coronary Artery Calcium Progression: A Case Cohort Analysis From ELSA‐Brasil

open access: yesArthritis Care &Research, EarlyView.
Objective To investigate the association between rheumatoid arthritis (RA) and coronary artery calcium (CAC) prevalence, incidence, and progression over four years in adults without prior cardiovascular disease. Methods A case‐cohort study within the Brazilian Longitudinal Study of Adult Health (ELSA‐Brasil) included 585 participants (86 patients with ...
Patrícia Fonseca Estrada   +7 more
wiley   +1 more source

Reversing Temozolomide Resistance in Glioblastoma Based on Cuproptosis‐Mediated Positive Feedback Loop

open access: yesAdvanced Science, EarlyView.
To effectively reverse TMZ resistance, this work proposes a cuproptosis‐mediated positive feedback loop that integrates mitochondrial dysfunction, ATP depletion, AMPK‐p53 signaling, and glycolytic inhibition, ultimately amplifying cell death. This cuproptosis‐mediated feedback loop simultaneously disrupts multiple resistance pathways in GBM, including ...
Wenjie Feng   +9 more
wiley   +1 more source

LITERATURE REVIEW: ANTIDIABETIC ACTIVITY OF HONEY [PDF]

open access: yes, 2022
Objective: The aim of this study is to determine the antidiabetic activity of honey for people with Type 2 diabetes mellitus (T2DM) by looking at its effect on glycemic response, glycemic control, and its synergistic combination with antidiabetic drugs ...
WULANDARI, ENDAH   +2 more
core   +1 more source

Gut Microbiota‐Derived Indole‐3‐Propionic Acid Alleviates Diabetic Osteoporosis Through Nrf2‐Mediated Ferroptosis Suppression

open access: yesAdvanced Science, EarlyView.
Diabetes‐associated dysbiosis is accompanied by reduced Clostridium abundance, impaired microbial tryptophan metabolism, and lower circulating indole‐3‐propionic acid (IPA). Exogenous IPA improves trabecular microarchitecture and bone formation and restores Nrf2‐associated antioxidant signaling in bone marrow mesenchymal stem cells, limiting iron ...
Jinwu Bai   +12 more
wiley   +1 more source

Traditional antidiabetic plants from Indonesia [PDF]

open access: yes, 2020
Background: Indonesia with its widely varied geographical features is rich with knowledge and practice in the utilization of plants for maintaining health and treating diseases, including for diabetes mellitus.
Budipramana, Krisyanti, Hartanti, Dwi
core   +2 more sources

Beyond Conventional: A Review of Phytochemical‐Hydrogel Systems Enhanced by AI and 3D Printing for Chronic Wound Management

open access: yesAdvanced Science, EarlyView.
This review systematically bridges chronic wound pathology with natural phytochemical hydrogel therapeutics. A pathology‐to‐phytochemical mechanistic mapping framework is established, linking specific wound hallmarks to targeted phytochemical interventions.
Yitao Zhou   +8 more
wiley   +1 more source

Association of DPP4 with esophageal stricture progression and the Hippo‐YAP pathway

open access: yesAnimal Models and Experimental Medicine, EarlyView.
This study establishes a comprehensive translational platform for esophageal stricture (ES) research by integrating a novel rat model with clinically relevant porcine validation. This study identifies DPP4 as a gene of interest associated with ES following endoscopic submucosal dissection, demonstrating that prophylactic DPP4 inhibition attenuates ...
Rui Wu   +5 more
wiley   +1 more source

Alpha-Glucosidase Inhibition and Hypoglycemic Activities of Sweitenia mahagoni Seed Extract

open access: yesHayati Journal of Biosciences, 2015
Inhibition of α-glucosidase and hypoglycemic activity are two effects commonly used to identify bioactive compounds with potential to treat diabetes.
TUTIK WRESDIYATI   +3 more
doaj   +1 more source

Exploring potential antidiabetic and anti-inflammatory flavonoids from Euphorbia humifusa with an integrated strategy

open access: yesFrontiers in Pharmacology, 2022
E. humifusa Willd, a monoecious annual plant, native to Eastern Asia, has been traditionally attributed to the treatment and prevention of miscellaneous diseases, including diabetes mellitus and its associated complications.
Tojofaniry Fabien Rakotondrabe   +9 more
doaj   +1 more source

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