Results 21 to 30 of about 4,971 (132)
Therapeutic Advances in Endocrinology and Metabolism, 2012 Hyponatremia is the most frequent electrolyte disorder and the syndrome of inappropriate antidiuretic hormone secretion (SIADH) accounts for approximately one-third of all cases.
Peter Gross
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Communication over the network of binary switches regulates the activation of A$_{2A}$ adenosine receptor [PDF]
PLoS Comp. Biol. (2015) 11(2): e1004044, 2014 Dynamics and functions of G-protein coupled receptors (GPCRs) are accurately regulated by the type of ligands that bind to the orthosteric or allosteric binding sites. To glean the structural and dynamical origin of ligand-dependent modulation of GPCR activity, we performed total $\sim$ 5 $\mu$sec molecular dynamics simulations of A$_{2A}$ adenosine ...
arxiv +1 more source
Treatment of euvolemic hyponatremia in the intensive care unit by urea [PDF]
, 2010 Introduction: Hyponatremia in the intensive care unit (ICU) is most commonly related to inappropriate secretion of antidiuretic hormone (SIADH). Fluid restriction is difficult to apply in these patients.
Andres, Caroline +3 more
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A Ligand-and-structure Dual-driven Deep Learning Method for the Discovery of Highly Potent GnRH1R Antagonist to treat Uterine Diseases [PDF]
arXiv, 2022 Gonadotrophin-releasing hormone receptor (GnRH1R) is a promising therapeutic target for the treatment of uterine diseases. To date, several GnRH1R antagonists are available in clinical investigation without satisfying multiple property constraints.
arxiv
Vasopressin Antagonists and Dilutional Hyponatremia [PDF]
, 2004 The paradox of dilutional hyponatremia, as described by Ovid two millennia ago, continues to apply to patients with advanced cirrhosis today: they have unremitting thirst despite vastly increased total body water. Hyponatremia of less than 130 mmol/L
D Mohamed Babatin, Samuel S Lee
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Targeting the vasopressin type-2 receptor for renal cell carcinoma therapy. [PDF]
, 2020 Arginine vasopressin (AVP) and its type-2 receptor (V2R) play an essential role in the regulation of salt and water homeostasis by the kidneys. V2R activation also stimulates proliferation of renal cell carcinoma (RCC) cell lines in vitro.
Calvet, James P +10 more
core
Human Luteinizing Hormone and Chorionic Gonadotropin Display Biased Agonism at the LH and LH/CG Receptors [PDF]
Scientific Reports, 7(940) (2017), 2018 Human luteinizing hormone (LH) and chorionic gonadotropin (hCG) have been considered biologically equivalent because of their structural similarities and their binding to the same receptor; the LH/CGR. However, accumulating evidence suggest that LH/CGR differentially responds to the two hormones triggering differential intracellular signaling and ...
arxiv +1 more source
Hyponatremia : Special Considerations in Older Patients [PDF]
, 2014 Acknowledgments Roy L.
Clarke, Jennifer M +4 more
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Control of gene expression by modulated self-assembly [PDF]
, 2011 Numerous transcription factors self-assemble into different order oligomeric species in a way that is actively regulated by the cell. Until now, no general functional role has been identified for this widespread process. Here we capture the effects of modulated self-assembly in gene expression with a novel quantitative framework.
arxiv +1 more source
Hyponatremia in Neurosurgical Patients
Креативная хирургия и онкологияHyponatremia refers to a common and potentially dangerous electrolyte imbalance observed in neurosurgical patients, particularly following traumatic brain injuries, subarachnoid hemorrhages, brain tumors, and pituitary surgeries.
О. A. Beylerli, A. A. Bukhvostov
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