Results 21 to 30 of about 2,128 (111)

Equivalent Efficacy and Decreased Rate of Overcorrection in Patients With Syndrome of Inappropriate Secretion of Antidiuretic Hormone Given Very Low-Dose Tolvaptan

open access: yesKidney Medicine, 2020
Rationale & Objective: Euvolemic hyponatremia often occurs due to the syndrome of inappropriate antidiuretic hormone secretion (SIADH). Vasopressin 2 receptor antagonists may be used to treat SIADH.
Ramy M. Hanna   +10 more
doaj  

Interplay between inflammatory reflex and energetic metabolism in endotoxaemia: A role for haem oxygenase 1?

open access: yesBritish Journal of Pharmacology, Volume 182, Issue 16, Page 3695-3709, August 2025.
Inflammation is vital for defence against injury and infection, but excessive inflammation can lead to tissue damage and disease. The central nervous system (CNS) helps regulate immune responses through neuroendocrine pathways, such as the hypothalamic–pituitary–adrenal axis and the anti‐inflammatory reflex, which limit systemic inflammation.
Evelin C. Cárnio   +5 more
wiley   +1 more source

Towards the convergent therapeutic potential of G protein‐coupled receptors in autism spectrum disorders

open access: yesBritish Journal of Pharmacology, Volume 182, Issue 14, Page 3044-3067, July 2025.
Abstract Autism spectrum disorders (ASDs) are diagnosed in 1/100 children worldwide, based on two core symptoms: deficits in social interaction and communication, and stereotyped behaviours. G protein‐coupled receptors (GPCRs) are the largest family of cell‐surface receptors that transduce extracellular signals to convergent intracellular signalling ...
Anil Annamneedi   +6 more
wiley   +1 more source

An Efficient Thiol‐ene Mediated Protocol for Thiolated Peptide Synthesis and On‐Resin Diversification

open access: yesChemistry – A European Journal, Volume 31, Issue 36, June 26, 2025.
Herein, a sequential acyl‐thiol‐ene/S‐deacetylation protocol for selective installation of thiol residues onto synthetic peptides, on‐resin, is demonstrated. The hydrothiolation/S‐deacetylation protocol offers a novel synthetic tool for direct peptide conjugation on‐resin and for the preparation of novel disulfide containing neuropeptides displaying ...
Nikita Ostrovitsa   +5 more
wiley   +1 more source

Evidence‐based management strategies for endocrine complications after pituitary adenoma surgery

open access: yesIbrain, Volume 11, Issue 2, Page 245-258, Summer 2025.
Based on the PIPOST (Population, Intervention, Professional, Outcome, Setting, and Type of Evidence) framework, evidence‐based medicine questions were developed, and a top‐down search was conducted according to the 6S model of the evidence pyramid. The literature sources were best practices, guidelines, expert consensuses, systematic reviews, meta ...
Xiaoju Miao   +7 more
wiley   +1 more source

Utility and Safety of Tolvaptan in Cirrhotic Patients with Hyponatremia: a Prospective Cohort Study

open access: yesAnnals of Hepatology, 2017
Introduction and aim: Hyponatremia is common in patients with decompensated cirrhosis and is associated with increased mortality. Tolvaptan, a vasopressor V2 receptor antagonist, can increase free water excretion, but its efficacy and safety in cirrhotic
Ji-Dong Jia   +16 more
doaj  

Association of Estimated Plasma Volume Status With Invasive Hemodynamics and All‐Cause Mortality in Patients With Liver Cirrhosis

open access: yesJGH Open, Volume 9, Issue 6, June 2025.
ABSTRACT Background Estimated plasma volume status (ePVS) correlates with intravascular congestion and prognosis in patients with heart failure. The ePVS relationship with invasive hemodynamic profiling and clinical outcomes in patients with liver cirrhosis (LC) remains unclear. Methods This single‐center retrospective cohort study included LC patients
Esteban Kosak Lopez   +12 more
wiley   +1 more source

Antimicrobial use and prescribing practices by equine veterinarians in Australia: Insights into reproduction, dentistry, compounding and use for nonbactericidal effects

open access: yesAustralian Veterinary Journal, Volume 103, Issue 6, Page 307-313, June 2025.
Background Antimicrobial resistance (AMR) is a problem for equine practitioners in Australia, but antimicrobial use in practice has been largely understudied. We aimed to evaluate equine veterinarians' intentions of prescribing antimicrobials in areas where we perceived there to be wide ranges of practice – dentistry, reproduction and for ...
LY Hardefeldt, K Thomas, L Begg
wiley   +1 more source

Advanced Materials for Biological Field‐Effect Transistors (Bio‐FETs) in Precision Healthcare and Biosensing

open access: yesAdvanced Healthcare Materials, Volume 14, Issue 13, May 16, 2025.
This review explores how advanced materials enhance Bio‐FETs for precision healthcare and biosensing. It covers their working principles, surface functionalization, and ultra‐sensitive detection capabilities. The integration of flexible designs, AI, and IoT for real‐time monitoring is discussed, along with challenges like material reproducibility and ...
Minal Pandey   +5 more
wiley   +1 more source

Recent Advances in Betaine: Extraction, Identification, and Bioactive Functions in Human Health

open access: yesFood Science &Nutrition, Volume 13, Issue 4, April 2025.
Betaine exhibits a range of biological activities, including antioxidant properties and the ability to enhance the preservation of fruits and vegetables post‐harvest. Betaine contributes positively to human health and is associated with various beneficial effects on well‐being.
Donglan Luo   +4 more
wiley   +1 more source

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