Results 31 to 40 of about 2,699 (106)

Short‐ and mid‐term effects of empagliflozin on sodium balance and fluid regulation in chronic heart failure

European Journal of Heart Failure, Volume 27, Issue 12, Page 3134-3141, December 2025.
Effects of empagliflozin on sodium and fluid regulation in chronic heart failure (CHF). EF, ejection fraction; NT‐proBNP, N‐terminal pro‐B‐type natriuretic peptide; NYHA, New York Heart Association. Aims Sodium–glucose co‐transporter 2 inhibitors have become a cornerstone in managing chronic heart failure (CHF).
Venera Bytyqi, Dennis Kannenkeril, Julie Kolwelter, Peter Linz, Agnes Bosch, Kristina Striepe, Marina V. Karg, Armin M. Nagel, Michael Uder, Mario Schiffer, Stephan Achenbach, Roland E. Schmieder   +11 more
wiley   +1 more source

The Evolving Landscape of Immunotoxicity: Charting Mechanisms and Future Strategies for Immune Checkpoint Inhibitor Adverse Events

Med Research, Volume 1, Issue 3, Page 322-358, December 2025.
ABSTRACT The use of immune checkpoint inhibitors (ICIs) has significantly improved the efficacy of cancer therapy, but their associated immune‐related adverse events (irAEs) can severely compromise treatment safety. This review systematically summarizes the core mechanisms underlying irAEs, which include multi‐organ damage resulting from T‐cell ...
Anqi Lin, Keyin Zheng, Aimin Jiang, Xufeng Huang, Qi Wang, András Hajdu, Zhengrui Li, Jian Zhang, Peng Luo   +8 more
wiley   +1 more source

Mechanisms of intrinsic osmolality and sodium detection by magnocellular neurosecretory neurons

Journal of Neuroendocrinology, Volume 37, Issue 12, December 2025.
Abstract The maintenance of extracellular fluid (ECF) osmolality and sodium concentration ([Na+]o) near optimal “set point” values sustains physiological functions and prevents pathological states such as hypo‐ and hypernatremia. The peptide hormones vasopressin (antidiuretic hormone) and oxytocin (a natriuretic hormone in rats) play key roles in this ...
Sandra Salgado‐Mozo, Anzala Murtaz, Joshua C. Wyrosdic, Julie O'Reilly‐Fong, Cristian Zaelzer, Mary P. LaPierre, Charles W. Bourque   +6 more
wiley   +1 more source

A randomised crossover trial of daridorexant for the treatment of chronic insomnia and nocturia

Journal of Sleep Research, Volume 34, Issue 6, December 2025.
Summary This double‐blind, placebo‐controlled, two‐way crossover trial evaluated the efficacy and safety of daridorexant in patients with chronic insomnia and comorbid nocturia. In total, 60 patients aged ≥55 years with insomnia complaints for ≥3 months, Insomnia Severity Index (ISI) ≥13 and ≥3 voids/night for ≥1 month were randomised (1:1) to ...
Katharina Lederer, Heike Benes, Alan Fine, Sylvia Shoffner, Sandro Bacchelli, David Castro Diaz, Jose Emilio Batista, Racheal Rowles, Tobias Di Marco, Michael Meinel   +9 more
wiley   +1 more source

Central Osmolality Sensing for Arginine Vasopressin Release Is Mediated by WNK1‐OSR1/SPAK‐Kv3.1 Cascade

The FASEB Journal, Volume 39, Issue 22, 30 November 2025.
Extracellular hyperosmolality extracts water from the catalytic center of WNK1 increasing the kinase activity. WNK1 phosphorylates and activates OSR1/SPAK leading to increases in Kv3.1 activity. Enhanced Kv3.1 activity accelerates repolarization, increasing afterhyperpolarization (AHP) and/or shortening AP width to increase action potential firing ...
Xin Jin, Jian Xie, Chia‐Wei Yeh, Yu‐Jui Li, Cheng‐Chang Lien, Chou‐Long Huang   +5 more
wiley   +1 more source

Vasopressin-2 receptor antagonists: potent but potentially dangerous drugs for the treatment of severe hyponatraemia secondary to syndrome of inappropriate antidiuretic hormone secretion [PDF]

Endocrine Abstracts, 2015
Vikki Tilliridou, Waiel A Bashari, Samson O Oyibo   +2 more
openaire   +1 more source

Why is the European Unifying Recommendation for Treating Syndrome of Inappropriate Antidiuretic Hormone (SIADH) and Cerebral Renal Salt Wasting Not Commonly Recommended in the US. [PDF]

Cureus
Imbriano L.
europepmc   +1 more source

SGLT2 Inhibitors as a Novel Therapeutic Strategy in SIADH-Induced Hyponatraemia: Emerging Evidence and Clinical Implications. [PDF]

J Clin Med
Kamran N, Mohammad M.
europepmc   +1 more source

Nocturia: An overview of current evaluation and treatment strategies. [PDF]

World J Methodol
Hou XY, Zhang L, Zhang ZJ, Xu W, Ye LW, Zhao HY, Suo XH, Hong AJ.   +7 more
europepmc   +1 more source

Acute neurological Behçet's disease complicated by a syndrome of inappropriate secretion of antidiuretic hormone. [PDF]

BMJ Case Rep
Kakehi E, Matsumoto Y, Sakurai S, Kotani K.   +3 more
europepmc   +1 more source