Results 31 to 40 of about 4,971 (132)
Application and Assessment of Deep Learning for the Generation of Potential NMDA Receptor Antagonists [PDF]
, 2020 Uncompetitive antagonists of the N-methyl D-aspartate receptor (NMDAR) have demonstrated therapeutic benefit in the treatment of neurological diseases such as Parkinson's and Alzheimer's, but some also cause dissociative effects that have led to the synthesis of illicit drugs.
arxiv +1 more source
Modeling of mouse experiments suggests that optimal anti-hormonal treatment for breast cancer is diet-dependent [PDF]
arXiv, 2023 Estrogen receptor positive breast cancer is frequently treated with anti-hormonal treatment such as aromatase inhibitors (AI). Interestingly, a high body mass index has been shown to have a negative impact on AI efficacy, most likely due to disturbances in steroid metabolism and adipokine production.
arxiv
Computational modeling approaches in gonadotropin signaling [PDF]
Theriogenology, 86(1):22-31 (2016), 2018 Follicle-stimulating hormone (FSH) and luteinizing hormone (LH) play essential roles in animal reproduction. They exert their function through binding to their cognate receptors, which belong to the large family of G protein-coupled receptors (GPCRs). This recognition at the plasma membrane triggers a plethora of cellular events, whose processing and ...
arxiv +1 more source
Progesterone Receptor Antagonists – A Novel Treatment for Severe Hyponatremia from the Endocrine Paraneoplastic Syndrome [PDF]
, 2021 Hyponatremia related to ectopic secretion of cancer cells of argininevasopressin (AVP) or atrial natriuretic peptide (ANP) is most commonlycaused by small cell lung cancer.
Check, Diane L. +2 more
core +2 more sources
Antidepressant-like Effects of Neuropeptide SF (NPSF) [PDF]
World Journal of Research and Review (WJRR) ISSN:2455-3956,
Volume-4, Issue-5, May 2017 Pages 26-30, 2020 Neuropeptide SF (NPSF) is a member of RFamide neuropeptides that play diverse roles in central nervous system. Little is know about the effects of NPSF on brain functions. Antidepressant-like effect of NPSF was studied in modified mice FST. NPSF showed the antidepressant-like effects by decreasing the immobility time and increasing the climbing and ...
arxiv
Evidence‐based management strategies for endocrine complications after pituitary adenoma surgery
Ibrain, EarlyView.Based on the PIPOST (Population, Intervention, Professional, Outcome, Setting, and Type of Evidence) framework, evidence‐based medicine questions were developed, and a top‐down search was conducted according to the 6S model of the evidence pyramid. The literature sources were best practices, guidelines, expert consensuses, systematic reviews, meta ...
Xiaoju Miao +7 more
wiley +1 more source
Divergent Evolution of Progesterone and Mineralocorticoid Receptors in Terrestrial Vertebrates and Fish Influences Endocrine Disruption [PDF]
arXiv, 2021 There is much concern about disruption of endocrine physiology regulated by steroid hormones in humans, other terrestrial vertebrates and fish by industrial chemicals, such as bisphenol A, and pesticides, such as DDT. These endocrine-disrupting chemicals influence steroid-mediated physiology in humans and other vertebrates by competing with steroids ...
arxiv
Australian Veterinary Journal, EarlyView.Background Antimicrobial resistance (AMR) is a problem for equine practitioners in Australia, but antimicrobial use in practice has been largely understudied. We aimed to evaluate equine veterinarians' intentions of prescribing antimicrobials in areas where we perceived there to be wide ranges of practice – dentistry, reproduction and for ...
LY Hardefeldt, K Thomas, L Begg
wiley +1 more source
Interventions for chronic non-hypovolaemic hypotonic hyponatraemia (Review) [PDF]
, 2018 Background : Chronic (present > 48 hours) non-hypovolaemic hyponatraemia occurs frequently, can be caused by various conditions, and is associated with shorter survival and longer hospital stays.
Craig, Jonathan C +5 more
core +2 more sources
Follicle-stimulating hormone receptor: Advances and remaining challenges [PDF]
In: Arun K. Shukla (ed.), dir., G Protein-Coupled Receptors:
Emerging Paradigms in Activation, Signaling and Regulation Part A (p. 1-58).
International Review of Cell and Molecular Biology, 338 (1\`ere ed.). USA :
Elsevier. 171 p. (2018), 2018 Follicle-stimulating hormone (FSH) is produced in the pituitary and is essential for reproduction. It specifically binds to a membrane receptor (FSHR) expressed in somatic cells of the gonads. The FSH/FSHR system presents many peculiarities compared to classical G protein-coupled receptors (GPCRs).
arxiv +1 more source