Results 71 to 80 of about 98,828 (291)

Prediction of efficacy for conversion from adjunctive therapy to monotherapy with eslicarbazepine acetate 800 mg once daily for partial-onset epilepsy

Clinical Pharmacology: Advances and Applications, 2017
Soujanya Sunkaraneni,1 Julie A Passarell,2 Elizabeth A Ludwig,2 Jill Fiedler-Kelly,2 Janet K Pitner,1 Todd A Grinnell,1 David Blum1 1Sunovion Pharmaceuticals Inc., Marlborough, MA, USA; 2Cognigen Corporation (a SimulationsPlus company), Buffalo, NY, USA ...
Sunkaraneni S, Passarell JA, Ludwig EA, Fiedler-Kelly J, Pitner JK, Grinnell TA, Blum D   +6 more
doaj  

Computational and Pharmacological Investigation of (E)-2-(4-Methoxybenzylidene)Cyclopentanone for Therapeutic Potential in Neurological Disorders

Drug Design, Development and Therapy, 2020
Sabah Farooq,1 Arif-ullah Khan,1 Muhammad Shahid Iqbal2 1Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad, Pakistan; 2Department of Clinical Pharmacy, College of Pharmacy, Prince Sattam Bin Abdulaziz University ...
Farooq S, Khan A, Iqbal MS
doaj  

Assessment of Initial Stay Time and Work‐Rest Scheduling Over Consecutive Moderate‐Intensity Workdays in Hot Environments in Young and Older Males and Females

American Journal of Industrial Medicine, EarlyView.
ABSTRACT Introduction Initial stay time (IST), the duration of continuous work before core temperature reaches 38.0°C, has been characterized in young and older adults but not across consecutive work periods or in conjunction with standard work‐rest cycles.
Glen P. Kenny, Katie E. Wagar, Roberto C. Harris‐Mostert, Kristina‐Marie T. Janetos, James J. McCormick, Kelli E. King, Leonidas G. Ioannou, Ronald J. Sigal, W. Shane Journeay, Fergus K. O'Connor   +9 more
wiley   +1 more source

Nicotinic Receptors in Sleep-Related Hypermotor Epilepsy: Pathophysiology and Pharmacology

Brain Sciences, 2020
Sleep-related hypermotor epilepsy (SHE) is characterized by hyperkinetic focal seizures, mainly arising in the neocortex during non-rapid eye movements (NREM) sleep. The familial form is autosomal dominant SHE (ADSHE), which can be caused by mutations in
Andrea Becchetti, Laura Clara Grandi, Giulia Colombo, Simone Meneghini, Alida Amadeo   +4 more
doaj   +1 more source

Clinical, Behavioral and Neuroradiological Phenotype in an Italian Cohort of Patients With Xia Gibbs Syndrome: A Multicenter Cross‐Sectional Study and Systematic Literature Review

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Heterozygous variants in the AHDC1 gene are associated with Xia Gibbs Syndrome (XGS), a genetic disorder with a highly variable phenotype. Cognitive impairment, motor delay, language delay, neonatal hypotonia, and sleep apnea are considered “cardinal” signs of the disease.
Giulia Cinelli, Stefania Della Vecchia, Patrizia Bergonzini, Elisa Caramaschi, Elisabetta Spezia, Claudia Parenti, Simona Filomena Madeo, Laura Lucaccioni, Cavalleri Francesca, Marisa Pugliese, Federico Raviglione, Clara Colonna, Olga Calabrese, Ilaria Stanghellini, Maria Carmen Marongiu, Enrico Biagioni, Anna Rita Ferrari, Roberta Battini, Lorenzo Iughetti   +18 more
wiley   +1 more source

Genetic and Immune Predictors for Hypersensitivity Syndrome to Antiepileptic Drugs [PDF]

, 2011
Hypersensitivity syndrome reactions (HSR) to antiepileptic drugs (AED) are associated with severe clinical cutaneous adverse reactions (SCAR).Our aims are: to assess HSRs to AEDs using the in vitro lymphocyte toxicity assay (LTA) in patients who ...
Lawrence Cohen, Manuela G. Neuman, Paul A. Hwang, Radu M. Nanau   +3 more
core   +1 more source

Cytosolic Phosphoenoylpyruvate Carboxykinase Deficiency: Clinical, Biochemical, and Genetic Features of Five Non‐Finnish Patients

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Cytosolic phosphoenoylpyruvate carboxykinase (PEPCK‐C) is an essential, rate‐limiting enzyme in the gluconeogenesis pathway. PEPCK‐C deficiency presents with hypoglycaemia, hyperlactataemia and hepatopathy, and was first reported in association with bi‐allelic PCK1 variants in 2014.
Isaac Bernhardt, Polona Le Quesne Stabej, Claire Hart, Mark De Hora, Sarah Hulley, Mark Anderson, Harry G. Leitch, Hugh Lemonde, Bryony Ryder, James Davison   +9 more
wiley   +1 more source

Treatment Effects of Onion (Allium cepa) and Ginger

Balkan Medical Journal, 2012
Objective: The aim of the present study was to evaluate the beneficial degree of sexual behavior in male rats after inducement of onion and ginger in lamotrigine receiving groups.
Hussein Nikniaz, Arash Davatgar Badie, Alireza Farnam, Arash Khaki   +3 more
doaj  

Effect of Methylphenidate in ADHD with Epilepsy or with EEG Abnormalities without Seizures

Pediatric Neurology Briefs, 2003
The safety and efficacy of methylphenidate (MPH) in the treatment of ADHD, group 1) with epilepsy and group 2) with EEG abnormalities without seizures, were determined in a study of 119 children (98 males, 21 females; ages 6 to 16 years) at Gazi ...
J Gordon Millichap
doaj   +1 more source

Modulation of neural cell membrane conductance by the herbal anxiolytic and antiepileptic drug aswal [PDF]

, 2000
To evaluate the effects of aswal on ionic fluxes and neuronal excitation, we performed extracellular and whole cell patch clamp recordings on CA1 pyramidal neurons of guinea pigs and Long-Evans rats.
Grunze, Heinz, Langosch, J., Loewenich, C. von, Walden, Jörg   +3 more
core   +1 more source