Results 1 to 10 of about 3,170,441 (213)

Efficacy and safety of antifibrinolytic agents in spinal surgery: a network meta-analysis [PDF]

Chinese Medical Journal, 2019
. Background:. Significant blood loss is still one of the most frequent complications in spinal surgery, which often necessitates blood transfusion. Massive perioperative blood loss and blood transfusion can create additional risks. Aprotinin, tranexamic
Lei Yuan, Yan Zeng, Zhong-Qiang Chen, Xin-Ling Zhang, Shuo Mai, Pan Song, Li-Yuan Tao, Qiang Shi   +7 more
doaj   +4 more sources

Efficacy and Safety of Antifibrinolytic Agents in Reducing Perioperative Blood Loss and Transfusion Requirements in Scoliosis Surgery: A Systematic Review and Meta-Analysis. [PDF]

PLoS ONE, 2015
BackgroundRoutine use of antifibrinolytic agents in spine surgery is still an issue of debate.ObjectiveTo gather scientific evidence for the efficacy and safety of antifibrinolytic agents including aprotinin, tranexamic acid (TXA) and epsilon ...
Meng Wang, Xin-Feng Zheng, Lei-Sheng Jiang   +2 more
doaj   +4 more sources

Efficacy and safety of using antifibrinolytic agents in spine surgery: a meta-analysis. [PDF]

PLoS ONE, 2013
PURPOSE: Spine surgery, particularly reconstructive surgery, can be associated with significant blood loss, and blood transfusion. Antifibrinolytic agents are used routinely to reduce bleeding in cardiac, orthopaedic, and hepatic surgery.
Chaoqun Yuan, Hailong Zhang, Shisheng He
doaj   +5 more sources

Antifibrinolytic Agents in Traumatic Haemorrhage [PDF]

PLoS Medicine, 2005
Among trauma patients who survive to reach hospital, exsanguination is a common cause of death. Could anti fibrinolytics reduce the death rate?
Tim Coats, Beverly Hunt, Ian Roberts, Haleema Shakur   +3 more
doaj   +13 more sources

Antifibrinolytic agents for reducing blood loss in scoliosis surgery in children. [PDF]

Cochrane Database Syst Rev, 2016
BACKGROUND This is an updated version of the original Cochrane review first published in 2008. Scoliosis surgery is often associated with substantial blood loss and potentially detrimental effects in children.
McNicol ED, Tzortzopoulou A, Schumann R, Carr DB, Kalra A.   +4 more
europepmc   +4 more sources

Do Antifibrinolytic Agents Reduce the Risk of Blood Transfusion in Children Undergoing Spinal Fusion?: A Propensity Score-matched Comparison Using a National Database. [PDF]

Spine (Phila Pa 1976), 2020
STUDY DESIGN Retrospective cohort. OBJECTIVE To evaluate the effectiveness and safety of antifibrinolytic (AF) agents in reducing perioperative blood transfusion in pediatric patients undergoing spinal fusion. SUMMARY OF BACKGROUND DATA The potential
Eisler LD, Lenke LG, Sun LS, Li G, Kim M.   +4 more
europepmc   +4 more sources

Effectiveness and safety of the use of antifibrinolytic agents in total-knee arthroplasty: A meta-analysis. [PDF]

Medicine (Baltimore), 2020
Background: Antifibrinolytic agents have been successfully used to reduce blood transfusion demand in patients undergoing elective knee arthroplasty. The purpose of this study was to investigate different antifibrinolytic agents for patients undergoing ...
Ma QM, Han GS, Li BW, Li XJ, Jiang T.
europepmc   +3 more sources

Predictors of Hematoma Enlargement in Patients with Spontaneous Intracerebral Hemorrhage Treated with Rapid Administration of Antifibrinolytic Agents and Strict Conservative Management. [PDF]

Korean J Neurotrauma, 2019
Objective Spontaneous intracerebral hemorrhage (ICH) is caused by the rupture of small blood vessels and other health problems. In ICH patients, hematoma enlargement is the most critical risk factor for poor outcomes.
Kim CH, Lee SW, Kim YH, Sung SK, Son DW, Song GS.   +5 more
europepmc   +4 more sources

Antifibrinolytic and Adjunct Hemostatic Agents: The Pediatric Extracorporeal Membrane Oxygenation Anticoagulation CollaborativE Consensus Conference. [PDF]

Pediatr Crit Care Med
OBJECTIVES: To derive systematic-review informed, modified Delphi consensus regarding antifibrinolytic and adjunct hemostatic agents in neonates and children supported with extracorporeal membrane oxygenation (ECMO) for the Pediatric ECMO Anticoagulation
Moynihan KM, Ryerson LM, Le J, Nicol K, Watt K, Gadepalli SK, Alexander PMA, Muszynski JA, Gehred A, Lyman E, Steiner ME, Pediatric Extracorporeal Membrane Oxygenation (ECMO) Anticoagulation CollaborativE (PEACE), in collaboration with the Pediatric Critical Care Blood Research Network (BloodNet), and Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network, and the Pediatric ECMO subgroup of PALISI and the Extracorporeal Life Support Organization (PediECMO).   +14 more
europepmc   +4 more sources

Antifibrinolytic agents in current anaesthetic practice [PDF]

British Journal of Anaesthesia, 2013
Antifibrinolytic drugs have become almost ubiquitous in their use during major surgery when bleeding is expected or commonplace. Inhibition of the fibrinolytic pathway after tissue injury has been consistently shown to reduce postoperative or traumatic ...
Erik Ortmann, Martin Besser, A. A. Klein
openalex   +2 more sources