Antifibrinolytic Agents in Traumatic Haemorrhage [PDF]
PLoS Medicine, 2005 Among trauma patients who survive to reach hospital, exsanguination is a common cause of death. Could anti fibrinolytics reduce the death rate?
Tim Coats +3 more
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Efficacy and safety of using antifibrinolytic agents in spine surgery: a meta-analysis. [PDF]
PLoS ONE, 2013 PURPOSE: Spine surgery, particularly reconstructive surgery, can be associated with significant blood loss, and blood transfusion. Antifibrinolytic agents are used routinely to reduce bleeding in cardiac, orthopaedic, and hepatic surgery.
Chaoqun Yuan, Hailong Zhang, Shisheng He
doaj +6 more sources
Efficacy and safety of antifibrinolytic agents in spinal surgery: a network meta-analysis [PDF]
Chinese Medical Journal, 2019 . Background:. Significant blood loss is still one of the most frequent complications in spinal surgery, which often necessitates blood transfusion. Massive perioperative blood loss and blood transfusion can create additional risks. Aprotinin, tranexamic
Lei Yuan +7 more
doaj +3 more sources
Efficacy and Safety of Antifibrinolytic Agents in Reducing Perioperative Blood Loss and Transfusion Requirements in Scoliosis Surgery: A Systematic Review and Meta-Analysis. [PDF]
PLoS ONE, 2015 Routine use of antifibrinolytic agents in spine surgery is still an issue of debate.To gather scientific evidence for the efficacy and safety of antifibrinolytic agents including aprotinin, tranexamic acid (TXA) and epsilon aminocaproic acid (EACA ...
Meng Wang +2 more
doaj +4 more sources
Antifibrinolytic agents for the prevention of postpartum hemorrhage
Thrombosis Update, 2021 Acute obstetric coagulopathy secondary to postpartum hemorrhage (PPH) is associated with poor outcome. There is evidence that Tranexamic Acid (TA), an antifibrinolytic drug, is an efficient tool of patient blood management in association with uterotonics
Anne-Sophie Bouthors +3 more
doaj +4 more sources
The effect of antifibrinolytic agents on the healing of modified Widman flaps in monkeys [PDF]
Journal of Periodontal Research, 1984 In vitro studies have shown that addition of antifibrinolytic agents to culture media containing explants of cat palatal mucosa will change the direction of the epithelial proliferation. Consequently, the epithelial cells migrate in an opposite direction to that expected, reaching the stratum corneum and spreading in the upper surface with the ...
C E Nasjleti +4 more
core +6 more sources
Antifibrinolytic agents for reducing blood loss in scoliosis surgery in children. [PDF]
Cochrane Database Syst Rev, 2016 This is an updated version of the original Cochrane review first published in 2008. Scoliosis surgery is often associated with substantial blood loss and potentially detrimental effects in children. Antifibrinolytic agents are often used to reduce perioperative blood loss.
McNicol ED +4 more
europepmc +6 more sources
Antifibrinolytic agents in current anaesthetic practice [PDF]
British Journal of Anaesthesia, 2013 Antifibrinolytic drugs have become almost ubiquitous in their use during major surgery when bleeding is expected or commonplace. Inhibition of the fibrinolytic pathway after tissue injury has been consistently shown to reduce postoperative or traumatic bleeding. There is also some evidence for a reduction of perioperative blood transfusion.
Andrew A. Klein +2 more
openaire +5 more sources
Valid Comparisons of Antifibrinolytic Agents Used in Cardiac Surgery [PDF]
Circulation, 2007 Bleeding is a major source of morbidity and mortality after cardiac surgical procedures. Patients who return to the operating room for bleeding have a 4-fold increase in mortality and a similar increase in the rate of sternal infection. The significance of this issue is underscored by the fact that patients undergoing cardiac surgery consume up to 30 ...
Charles R. Bridges
openaire +4 more sources
Salts of S-(+)-Ibuprofen Formed via Its Reaction with the Antifibrinolytic Agents Aminocaproic Acid and Tranexamic Acid: Synthesis and Characterization [PDF]
Crystals, 2023 The paucity of multi-component compounds containing the non-steroidal anti-inflammatory drug (NSAID) S-(+)-ibuprofen (S-IBU) in combination with other drugs prompted the present study, which describes 1:1 salts of this active pharmaceutical ingredient ...
Hannah M. Frösler +3 more
doaj +2 more sources