Synthesis and Hemostatic Activity of New Amide Derivatives
Molecules, 2022 Eight dipeptides containing antifibrinolytic agents (tranexamic acid, aminocaproic acid, 4-(aminomethyl)benzoic acid, and glycine—natural amino acids) were synthesized in a three-step process with good or very good yields.
Lukasz Banach +9 more
doaj +1 more source
Preventing perioperative bleeding in patients with inherited bleeding disorders [PDF]
, 2017 Data sources: Cochrane Cystic Fibrosis and Genetic Disorders Group's Coagulopathies Trials Register, a regularly updated database informed by trials identified within electronic databases including MEDLINE.
Beacher, Nicholas, Watterson, Colin
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Antifibrinolytic role of a bee venom serine protease inhibitor that acts as a plasmin inhibitor. [PDF]
PLoS ONE, 2012 Bee venom is a rich source of pharmacologically active substances. In this study, we identified a bumblebee (Bombus ignitus) venom Kunitz-type serine protease inhibitor (Bi-KTI) that acts as a plasmin inhibitor.
Young Moo Choo +7 more
doaj +1 more source
Secondary Hematoma Expansion and Perihemorrhagic Edema after Intracerebral Hemorrhage: From Bench Work to Practical Aspects. [PDF]
, 2017 Intracerebral hemorrhages (ICH) represent about 10-15% of all strokes per year in the United States alone. Key variables influencing the long-term outcome after ICH are hematoma size and growth.
Lim-Hing, Krista, Rincon, Fred
core +2 more sources
COMPARISON OF HEMOSTASIS WITH TRANEXAMIC ACID IN TOTAL KNEE ARTHROPLASTY
Acta Ortopédica Brasileira, 2021 Objective: To compare the use of intravenous and topical tranexamic acid (TXA) in unilateral primary total knee arthroplasty (TKA) in relation to blood loss and complications inherent to the medication.
OTÁVIO MONTOVANELLI MONTEIRO +5 more
doaj +1 more source
Aprotinin may increase mortality in low and intermediate risk but not in high risk cardiac surgical patients compared to tranexamic acid and ε-aminocaproic acid - a meta-analysis of randomised and observational trials of over 30.000 patients [PDF]
, 2013 Background: To compare the effect of aprotinin with the effect of lysine analogues (tranexamic acid and ε-aminocaproic acid) on early mortality in three subgroups of patients: low, intermediate and high risk of cardiac surgery.
Herrmann, Eva +3 more
core +3 more sources
Disseminated intravascular and intracardiac thrombosis after cardiopulmonary bypass
Journal of Anaesthesiology Clinical Pharmacology, 2017 Massive intracardiac and intravascular thrombosis is a rare complication following cardiopulmonary bypass (CPB). Most of the cases of the disseminated thrombosis have been reported in patients undergoing complex cardiac surgeries and those receiving ...
Deepak K Tempe +4 more
doaj +1 more source
Effect of tranexamic acid in traumatic brain injury: a nested randomised, placebo controlled trial (CRASH-2 Intracranial Bleeding Study). [PDF]
, 2011 OBJECTIVE: To assess the effect of tranexamic acid (which reduces bleeding in surgical patients and reduces mortality due to bleeding in trauma patients) on intracranial haemorrhage in patients with traumatic brain injury.
CRASH-2 Collaborators, Intracranial Bleeding Study
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Anti-fibrinolytic agents in post partum haemorrhage: a systematic review
BMC Pregnancy and Childbirth, 2009 Background Post partum haemorrhage is a leading cause of maternal death worldwide. It also contributes to maternal morbidity as women may require a hysterectomy to control bleeding, or may require a blood transfusion, which can transmit viral infections.
Blackhall Karen +4 more
doaj +1 more source
Management of dental extraction in patients with Haemophilia A and B: a report of 58 extractions [PDF]
, 2014 Objectives: Patients with inherited bleeding disorders are at high risk of bleeding following oral surgery and present challenges to the oral surgeons. Aim of this study was to report our experience in dental extraction in patients exhibiting Haemophilia
Peisker, Andre +2 more
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