Results 61 to 70 of about 7,481 (249)

Evaluating Tranexamic Acid Dosing Strategies for Postpartum Hemorrhage: A Population Pharmacokinetic Approach in Pregnant Individuals

The Journal of Clinical Pharmacology, EarlyView.
Abstract Tranexamic acid (TXA) is used for the treatment and occasionally prevention of postpartum hemorrhage (PPH); however, questions still remain regarding dosing regimen optimization. This study evaluated TXA pharmacokinetic (PK) data from four clinical trials (NCT: 04274335, 03287336, 00872469, and 02797119) conducted in pregnant participants ...
Allison Dunn, Mina Felfeli, Sebastian M. Seifert, Sixtine Gilliot, Anne‐Sophie Ducloy‐Bouthors, Haleem Shakur‐Still, Amber Geer, Stanislas Grassin‐Delyle, Naomi L. Luban, Johannes N. van den Anker, Jogarao V. S. Gobburu, Ian Roberts, Homa K. Ahmadzia   +12 more
wiley   +1 more source

Effectiveness of Octocog Alfa (BAY 81‐8973) to Treat People With Haemophilia A Enrolled in the ATHNdataset, Including Under‐Represented Subgroups

European Journal of Haematology, EarlyView.
ABSTRACT Objectives To evaluate the real‐world effectiveness of octocog alfa (BAY 81‐8973; Kovaltry) in people with haemophilia A (PwHA), including under‐represented subgroups. Methods We retrospectively analysed the American Thrombosis and Hemostasis Network (ATHN) dataset to identify the characteristics, treatment/clinical histories and annualised ...
Martin Chandler, Thomas Moulton, Lena Charafi, Jessica Charlet, Michael Recht   +4 more
wiley   +1 more source

The use of fibrinolysis inhibitors in cardiac surgery with cardiopulmonary bypass (literature review)

Вестник анестезиологии и реаниматологии
In cardiac surgery with cardiopulmonary bypass (CPB) is a common complication. The incidence of this complication in cardiac surgery patients is estimated at about 10%.
V. Yu. Medvedeva, K. N. Khrapov, A. A. Khryapa, K. Yu. Kankova   +3 more
doaj   +1 more source

Bleeding related to disturbed fibrinolysis [PDF]

, 2016
The components and reactions of the fibrinolysis system are well understood. The pathway has fewer reactants and interactions than coagulation, but the generation of a complete quantitative model is complicated by the need to work at the solid‐liquid ...
Cawthern K.M., Colucci G., Dombret H., Goodpasture E.W., Janning M., Kashuk J.L., Kluft C., Lisman T., Longstaff C., Miura O., Oudijk E.J., Rick M.E., Rijken D.C.   +12 more
core   +1 more source

Dental Management for People With Congenital Haemophilia: A Systematic Review of the Existing Dental Recommendations

Haemophilia, EarlyView.
ABSTRACT Introduction Haemophilia is the most common inherited bleeding disorder. Dental management for people with haemophilia (PwH) (both A and B) is challenging, as dental procedures may initiate bleeding episodes that may be difficult to control. Objectives This systematic review aimed to evaluate and summarize the existing dental guidelines that ...
Mathangi Kumar, Sulochana Badagabettu, Keerthilatha M. Pai, Judith Angelitta Noronha, Baby S. Nayak, Penny McCarthy   +5 more
wiley   +1 more source

Glanzmann thrombasthenia: genetic basis and clinical correlates

Haematologica, 2020
Glanzmann thrombasthenia (GT) is an autosomal recessive disorder of platelet aggregation caused by quantitative or qualitative defects in integrins αIIb and β3. These integrins are encoded by the ITGA2B and ITGB3 genes and form platelet glycoprotein (GP)
Juliana Perez Botero, Kristy Lee, Brian R Branchford, Paul F Bray, Kathleen Freson, Michele P. Lambert, Minjie Luo, Shruthi Mohan, Justyne E. Ross, Wolfgang Bergmeier, Jorge Di Paola   +10 more
doaj   +1 more source

European Management of Glanzmann's Thrombasthenia: A Survey of Current Clinical Practice

Haemophilia, EarlyView.
ABSTRACT Introduction Glanzmann's thrombasthenia is a rare inherited platelet disorder characterized by a lack of platelet aggregation. Patients tend to be diagnosed in early childhood with treatment strategies involving a multifaceted approach to prevent and manage bleeding episodes.
Mathieu Fiore, Andrea Artoni, Robert Klamroth, Mary Mathias, Roger Schutgens, Roseline d'Oiron, EAHAD Glanzmann Thrombasthenia Working Group   +6 more
wiley   +1 more source

Inhibitors in Patients with Congenital Bleeding Disorders Other Than Hemophilia [PDF]

, 2017
The most worrying complication of replacement therapy for severe hemophilia A and B is currently the occurrence of inhibitory alloantibodies against infused factor VIII and factor IX, respectively.
Franchini, Massimo, Liumbruno, Giancarlo Maria, Marano, Giuseppe, Mengoli, Carlo, Piccinini, Vanessa, Pupella, Simonetta, Vaglio, Stefania   +6 more
core   +1 more source

Variability in viscoelastic haemostatic assay in major haemorrhage protocols: A unified approach or mixed signals?

Transfusion Medicine, EarlyView.
Abstract Background and Objectives Viscoelastic haemostatic assays (VHA) are part of patient blood management (PBM) for bleeding, associated with reduced transfusions. This study reviewed all major haemorrhage protocols (MHPs) using VHA in Queensland, Australia, and assessed variability.
Akmez Latona, James Winearls, Kate Hill, Michelle Spanevello, Biswadev Mitra   +4 more
wiley   +1 more source

The usefulness of tranexamic acid for bleeding symptoms of chronic consumptive coagulopathy complicated by aortic disease: a single-institute, retrospective study of 14 patients

Thrombosis Journal, 2023
Background Tranexamic acid (TXA) is an antifibrinolytic drug that blocks lysine-binding sites on the profibrinolytic enzyme plasminogen. Aortic diseases with chronic consumption coagulopathy may lead to disseminated intravascular coagulation (DIC) and ...
Naruko Suzuki, Nobuaki Suzuki, Yuka Kawaguchi, Shuichi Okamoto, Takeshi Kanematsu, Akira Katsumi, Atsuo Suzuki, Shogo Tamura, Tetsuhito Kojima, Hitoshi Kiyoi, Tadashi Matsushita   +10 more
doaj   +1 more source