Results 1 to 10 of about 473,247 (336)
Frontiers in Cellular and Infection Microbiology, 2021 In many ways, fungal diseases are forgotten or neglected. Given the significantly lower frequency compared to similar bacterial etiologies across the spectrum of infectious syndromes, it makes sense that anti-bacterial agents have seen the bulk of development in recent decades.
Todd Patrick McCarty +2 more
openaire +3 more sources
Metabolites, 2020 We reviewed the licensed antifungal drugs and summarized their mechanisms of action, pharmacological profiles, and susceptibility to specific fungi. Approved antimycotics inhibit 1,3-β-d-glucan synthase, lanosterol 14-α-demethylase, protein, and deoxyribonucleic acid biosynthesis, or sequestrate ergosterol.
Jiří Houšť +2 more
openaire +4 more sources
In vitro activities of Traganum nudatum and Mentha pulegium extracts combined with amphotericin B against Candida albicans in production of hydrolytic enzymes [PDF]
Current Medical Mycology, 2020 Background and Purpose: Candida albicans is an important microorganism in the normal flora of a healthy subject; however, it has an expedient pathogenic character that induces hydrolytic virulence.
Ikram Tefiani +2 more
doaj +1 more source
Journal of Fungi, 2021 Fungal infections represent an increasing public health crisis [...]
openaire +3 more sources
Proceedings of the National Academy of Sciences, 2007 Fungi are increasingly identified as major pathogens in bloodstream infections, often involving indwelling devices. Materials with antifungal properties may provide an important deterrent to these infections. Here we describe amphogel, a dextran-based hydrogel into which amphotericin B is adsorbed.
Zumbuehl, Andréas +10 more
openaire +4 more sources
New Approaches for Cryptococcosis Treatment
Microorganisms, 2020 Cryptococcosis is an important opportunistic infection and a leading cause of meningitis in patients with HIV infection. The antifungal pharmacological treatment is limited to amphotericin B, fluconazole and 5- flucytosine.
Cristina de Castro Spadari +3 more
doaj +1 more source
Frontiers in Microbiology, 2020 Topical drug administration is frequently used for the treatment of vaginal candidiasis; however, most formulations using this route do not provide prolonged drug release.
Fernanda Walt Mendes da Silva de Bastiani +5 more
doaj +1 more source
Nanoliposome-loaded antifungal drugs for dermal administration: A review [PDF]
Current Medical Mycology, 2021 Cutaneous fungal infections are the fourth most common health problem, which involves approximately billion people worldwide. Drug delivery to the skin seems to be the best choice for superficial fungal infections.
Peyman Asadi +4 more
doaj +1 more source
Microbiology Spectrum, 2022 Bg_9562, a prophage tail-like protein was earlier shown to be required for bacterial mycophagy by Burkholderia gladioli strain NGJ1. The purified protein exhibited broad-spectrum antifungal activity; however, the structural and mechanistic details vis-à ...
Pankaj Kumar Sahoo +5 more
doaj +1 more source
Frontiers in Microbiology, 2020 The identification of cellular targets for antifungal compounds is a cornerstone for the development of novel antimycotics, for which a significant need exists due to increasing numbers of susceptible patients, emerging pathogens, and evolving resistance.
Jasmin Binder +5 more
doaj +1 more source