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Molecular mechanisms governing antifungal drug resistance
npj antimicrobials and resistance, 2023 Fungal pathogens are a severe public health problem. The leading causative agents of systemic fungal infections include species from the Candida, Cryptococcus, and Aspergillus genera.
Yunjin Lee, Nicole Robbins, L. Cowen
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Tackling the emerging threat of antifungal resistance to human health
Nature Reviews Microbiology, 2022 Invasive fungal infections pose an important threat to public health and are an under-recognized component of antimicrobial resistance, an emerging crisis worldwide.
M. Fisher +19 more
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Chitosan and Chitosan Nanoparticles: Parameters Enhancing Antifungal Activity
Molecules, 2023 Chitosan (CS), a biopolymer derived from chitin, is known for strong antifungal activity while being biodegradable, biocompatible, and non-toxic. Because of its characteristic it has been widely used in control of fungal pathogens. Antifungal activity of
P. Poznański, A. Hameed, W. Orczyk
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The Antifungal Pipeline: Fosmanogepix, Ibrexafungerp, Olorofim, Opelconazole, and Rezafungin
Drugs, 2021 The epidemiology of invasive fungal infections is changing, with new populations at risk and the emergence of resistance caused by the selective pressure from increased usage of antifungal agents in prophylaxis, empiric therapy, and agriculture.
M. Hoenigl +11 more
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Emerging Antifungal Targets and Strategies
International Journal of Molecular Sciences, 2022 Despite abundant research in the field of antifungal drug discovery, fungal infections remain a significant healthcare burden. There is an emerging need for the development of novel antifungals since those currently available are limited and do not ...
Marija Ivanov +2 more
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Frontiers in Tropical Diseases, 2021 Introduction The increase in antimicrobial consumption contributes to the emergence of antimicrobial resistance (AMR). Many studies have investigated the patterns of antibacterial consumption and antibacterial resistance.
Hafidh Hamim +8 more
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Antifungal Drug Resistance: Molecular Mechanisms in Candida albicans and Beyond.
Chemical Reviews, 2020 Fungal infections are a major contributor to infectious disease-related deaths across the globe. Candida species are among the most common causes of invasive mycotic disease, with Candida albicans reigning as the leading cause of invasive candidiasis ...
Yunjin Lee +3 more
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Candida auris: Epidemiology, biology, antifungal resistance, and virulence
PLoS Pathogens, 2020 First described in 2009 in Japan, the emerging multidrug-resistant fungal pathogen Candida auris is becoming a worldwide public health threat that has been attracting considerable attention due to its rapid and widespread emergence over the past decade ...
Han Du +5 more
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Candidiasis and Mechanisms of Antifungal Resistance
Antibiotics, 2020 Candidiasis can be present as a cutaneous, mucosal or deep-seated organ infection, which is caused by more than 20 types of Candida sp., with C. albicans being the most common.
Somanon Bhattacharya +2 more
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Journal of Fungi, 2021 The use of metal nanoparticles is considered a good alternative to control phytopathogenic fungi in agriculture. To date, numerous metal nanoparticles (e.g., Ag, Cu, Se, Ni, Mg, and Fe) have been synthesized and used as potential antifungal agents ...
Aida R Cruz-Luna +3 more
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