Results 41 to 50 of about 326,437 (300)

Evaluating the in vitro anti-diabetic activity of Bryonia dioica root extracts supported by molecular docking analysis

Digital Chinese Medicine
Objective: To evaluate the in vitro anti-diabetic effects of Bryonia dioica roots extracts, including water-acetone extracts and their ethyl acetate and butanol fractions, and chloroform-methanol extracts. Methods: The total phenolic, flavonoid, flavonol,
Fekhikher Zohra, Benariba Nabila, Radia Brixi Gormat, Hassain Reda, Abdelli Imen, Z. Sekkal Fatima, Kachekouche Youssouf, Taibi Warda, Brikci Sohayb Bekkal, Terki Mohammed, Benramdane Hanane, Adjdir Sara   +11 more
doaj   +1 more source

Polyene macrolide antifungal drugs trigger interleukin-1β secretion by activating the NLRP3 inflammasome. [PDF]

, 2011
The use of antimycotic drugs in fungal infections is based on the concept that they suppress fungal growth by a direct killing effect. However, amphotericin and nystatin have been reported to also trigger interleukin-1β (IL-1β) secretion in monocytes but
Rupanagudi Khader Valli, Khader Valli Rupanagudi, Allam, R., Anders Hans-Joachim, Darisipudi, M.N., Ramanjaneyulu Allam, Allam Ramanjaneyulu, Murthy Narayana Darisipudi, Hans-Joachim Anders, Rupanagudi, K.V., Rupanagudi, Khader Valli, Anders, Hans-Joachim, Anders, H.J., Darisipudi, Murthy Narayana, Darisipudi Murthy Narayana, Allam, Ramanjaneyulu   +15 more
core   +2 more sources

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Antifungal hydrogels [PDF]

Proceedings of the National Academy of Sciences, 2007
Fungi are increasingly identified as major pathogens in bloodstream infections, often involving indwelling devices. Materials with antifungal properties may provide an important deterrent to these infections. Here we describe amphogel, a dextran-based hydrogel into which amphotericin B is adsorbed.
Zumbuehl, Andréas, Ferreira, Lino, Kuhn, Duncan, Astashkina, Anna, Lon, Lisa, Yeo, Yoon, Iaconis, Tiffany, Ghannoum, Mahmoud, Fink, Gerald R., Langer, Robert, Kohane, Daniel S.   +10 more
openaire   +3 more sources

Antifungal compounds in Geraldton waxflower tissues

, 2003
Geraldton waxflower is the most economically important native Australian cut flower export. Infection of waxflower by Botrytis cinerea can lead to unacceptable levels of flower abscission after harvest.
Khambay, BPS, Khambay, B. P. S., Terry, LA, Joyce, DC, Terry, L. A., Joyce, D. C.   +5 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Fatty Acids and Oxylipins as Antifungal and Anti-Mycotoxin Agents in Food: A Review

Toxins, 2021
Fungal contamination of food, especially by mycotoxigenic fungi, not only reduces the quality of the food, but can also cause serious diseases, thus posing a major food safety challenge to humans.
Mei Qiu, Yaling Wang, Lijun Sun, Qi Deng, Jian Zhao   +4 more
doaj   +1 more source

Comparison of results of fluconazole and voriconazole disk diffusion testing for Candida spp. with results from a central reference laboratory in the ARTEMIS DISK Global Antifungal Surveillance

, 2009
The accuracy of antifungal susceptibility testing is important for reliable resistance surveillance and for the clinical management of patients with serious infections due to Candida spp.
KROEGER J, HOLLIS RJ, TENDOLKAR S, PARTICIPANT OF GLOBAL ANTIFUNGAL SURVEILLANCE GROUP, GHEZZI, Maria Cristina, MESSER SA, RAPONI, Giammarco, DIEKEMA DJ, PFALLER MA, BOYKEN L   +9 more
core   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Automated Detection and Antifungal Susceptibility Profile of Candida Species Isolated from Blood Cultures of Neonatal ICU Patients Using MALDI-TOF and VITEK: Insights from a Tertiary Care Center in Rajasthan [PDF]

Pediatric Infectious Disease
Aims and background: Accurate identification of Candida species and their antifungal susceptibility (AFS) profiles, especially in neonates, is important in the era of emerging pathogens like Candida and the growing resistance to commonly used antifungal ...
Mamta Lamba, Snigdha Purohit, Vijaylaxmi Meena, Rekha Bachhiwal, Rajni Sharma   +4 more
doaj   +1 more source