Results 21 to 30 of about 326,437 (300)

Genetic and structural validation of Aspergillus fumigatus UDP-N-acetylglucosamine pyrophosphorylase as a potential antifungal target [PDF]

, 2013
The sugar nucleotide UDP-N-acetylglucosamine (UDP-GlcNAc) is an essential metabolite in both prokaryotes and eukaryotes. In fungi, it is the precursor for the synthesis of chitin, an essential component of the fungal cell wall.
Raimi, Olawale G., Hurtado-Guerrero, Ramon, Ibrahim, Adel F. M., Urbaniak, Mick, Ferguson, Michael A. J., van Aalten, Daan M. F., Du, Ting, Fang, Wenxia   +7 more
core   +5 more sources

Pharmacodynamic Effects of Simulated Standard Doses of Antifungal Drugs against Aspergillus Species in a New In Vitro Pharmacokinetic/Pharmacodynamic Model [PDF]

, 2011
In conventional MIC tests, fungi are exposed to constant drug concentrations, whereas in vivo, fungi are exposed to changing drug concentrations.
Thomas J. Walsh, Emmanuel Roilides, Aristea Velegraki, Walsh, Thomas, Zerva, Loukia, Meletiadis, Joseph, Joseph Meletiadis, Roilides, Emmanuel, Rafal Al-Saigh, Velegraki, Aristea, Loukia Zerva, Al Saigh, Rafal   +11 more
core   +1 more source

The Essential Thioredoxin Reductase of the Human Pathogenic Mold Aspergillus fumigatus Is a Promising Antifungal Target

Frontiers in Microbiology, 2020
The identification of cellular targets for antifungal compounds is a cornerstone for the development of novel antimycotics, for which a significant need exists due to increasing numbers of susceptible patients, emerging pathogens, and evolving resistance.
Jasmin Binder, Yana Shadkchan, Nir Osherov, Sven Krappmann, Sven Krappmann, Sven Krappmann   +5 more
doaj   +1 more source

Chemical Composition of Essential Oilsof Thymus and Mentha Speciesand Their Antifungal Activities [PDF]

, 2009
The potential antifungal effects of Thymus vulgaris L., Thymus tosevii L., Mentha spicata L., and Mentha piperita L. (Labiatae) essential oils and their components against 17 micromycetal food poisoning, plant, animal and human pathogens are presented ...
Marin, P.D., Petar D. Marin, Vlatka Vajs, Dejan D. Brkić, Marin, Petar D, Jelena Vukojević, Vajs, V., Vajs, Vlatka E, van Griensven, L.J.L.D., Marin, Petar D., Brkić, Dejan, Marin, Petar, Brkić, Dejan D, Leo J. L. D. Van Griensven, Van Griensven, Leo J. L. D., Leo J. L. D. van Griensven, Vukojević, J, Brkić, D D, Griensven, L.J.L.D., van, Dejan D. Brkić, van Griensven, Leo JLD, Jelena Vukojević, Vukojević, Jelena B., Van Griensven, Leo J.L.D., Vukojevic,, J., Vajs, Vlatka, Sokovic,, M.D., Marina D. Soković, Marina D. Soković, Soković, Marina, Vukojević, Jelena, Brkic, D.D.   +31 more
core   +1 more source

Flucytosine and cryptococcosis: time to urgently address the worldwide accessibility of a 50-year-old antifungal. [PDF]

, 2013
Current, widely accepted guidelines for the management of HIV-associated cryptococcal meningoencephalitis (CM) recommend amphotericin B combined with flucytosine (5-FC) for ≥2 weeks as the initial induction treatment of choice.
A. Loyse, Dromer, F, Day, J, Lortholary, O, O. Lortholary, Harrison, TS, F. Dromer, Day, Jeremy, T. S. Harrison, J. Day, Loyse, A   +10 more
core   +1 more source

Use of volatile fingerprints for rapid screening of antifungal agents for efficacy against dermatophyte Trichophyton species [PDF]

, 2010
The potential of using an electronic nose (E-nose) as a rapid technique for screening the responses of dermatophytes to antifungal agents was studied.
Adriaans, B, Barr, Hugh, Magan, Naresh, Sahgal, N, Sahgal, Natasha, Barr, H, Magan, N, Naraghi, Kamran, Adriaans, Beverley, Naraghi, K   +9 more
core   +1 more source

Modes of action of the new arylguanidine abafungin beyond interference with ergosterol biosynthesis and in vitro activity against medically important fungi [PDF]

, 2008
Background: In contrast to the increasing numbers of agents for the treatment of invasive fungal infections, discoveries of new antifungal agents with therapeutic value in dermatomycoses are reported only rarely.
Borelli, Claudia, Korting, Hans Christian, Tietjen, K., Niewerth, M., Schaller, M., Lang-Fugmann, S., Tiemann, R., Fugmann, B., Baasner, B., Nocker, K., Berg, D.   +10 more
core   +1 more source

Antifungal Secondary Metabolites Against Blast Fungus Magnaporthe oryzae

, 2022
Magnaporthe oryzae is one of the most destructive fungal pathogen causing blast diseases in at least 50 grass species including wheat and rice. Although there has been comprehensive study on the fungicidal control of blast diseases, the development of ...
Islam, Tofazzal, Chakraborty, Moutoshi
core   +1 more source

Phenotypic and Proteomic Analysis of the Aspergillus fumigatus ΔPrtT, ΔXprG and ΔXprG/ΔPrtT Protease-Deficient Mutants

Frontiers in Microbiology, 2017
Aspergillus fumigatus is the most common mold species to cause disease in immunocompromised patients. Infection usually begins when its spores (conidia) are inhaled into the airways, where they germinate, forming hyphae that penetrate and destroy the ...
Einav Shemesh, Benjamin Hanf, Benjamin Hanf, Shelly Hagag, Shani Attias, Yana Shadkchan, Boris Fichtman, Amnon Harel, Thomas Krüger, Thomas Krüger, Axel A. Brakhage, Axel A. Brakhage, Olaf Kniemeyer, Olaf Kniemeyer, Nir Osherov   +14 more
doaj   +1 more source

Overproduction of gentamicin B in industrial strain Micromonospora echinospora CCTCC M 2018898 by cloning of the missing genes genR and genS

Metabolic Engineering Communications, 2019
In pharmaceutical industry, isepamicin is mainly manufactured from gentamicin B, which is produced by Micromonospora echinospora as a minor component of the gentamicin complex.
Yingying Chang, Baozhong Chai, Yunkun Ding, Min He, Linghui Zheng, Yun Teng, Zixin Deng, Yi Yu, Tiangang Liu   +8 more
doaj   +1 more source