Results 61 to 70 of about 3,492,596 (401)
An aptamer-biosensor for azole class antifungal drugs [PDF]
, 2017 This report describes the development of an aptamer for sensing azole antifungal drugs for therapeutic drug monitoring. Modified Synthetic Evolution of Ligands through Exponential Enrichment (SELEX) was used to discover a DNA aptamer recognizing azole class antifungal drugs.
arxiv +1 more source
Fungal biofilm resistance [PDF]
, 2012 Fungal biofilm infections have become increasingly recognised as a significant clinical problem. One of the major reasons behind this is the impact that these have upon treatment, as antifungal therapy often fails and surgical intervention is required ...
Rajendran, Ranjith +3 more
core +4 more sources
Saudi Pharmaceutical Journal, 2023 Human pathogenic fungi are responsible for causing a range of infection types including mucosal, skin, and invasive infections. Life-threatening and invasive fungal infections (FIs) are responsible for mortality and morbidity, especially for individuals ...
Osama A. Madkhali
doaj
In pursuit of the ideal antifungal agent for Candida infections: high-throughput screening of small molecules [PDF]
, 2014 Candida infections have created a great burden on the public healthcare sector. The situation is worsened by recent epidemiological changes. Furthermore, the current arsenal of antifungal agents is limited and associated with undesirable drawbacks ...
Samaranayake, Lakshman P. +2 more
core +1 more source
Fungal Drug Response and Antimicrobial Resistance
Journal of Fungi, 2023 Antifungal resistance is a growing concern as it poses a significant threat to public health. Fungal infections are a significant cause of morbidity and mortality, especially in immunocompromised individuals.
Paloma Osset-Trénor +2 more
doaj +1 more source
Future Medicinal Chemistry, 2019 Fungal infections are a worldwide problem associated with high morbidity and mortality. There are relatively few antifungal agents, and resistance has emerged within these pathogens for the newest antifungal drugs. As the fungal cell wall is critical for
S. Hasim, Jeffrey J. Coleman
semanticscholar +1 more source
Transcriptome assembly and profiling of Candida auris reveals novel insights into biofilm-mediated resistance [PDF]
, 2018 Candida auris has emerged as a significant global nosocomial pathogen. This is primarily due to its antifungal resistance profile but also its capacity to form adherent biofilm communities on a range of clinically important substrates.
Ben-Ami +63 more
core +3 more sources
Chalcone derivatives as potential antifungal agents: Synthesis, and antifungal activity
Journal of Advanced Pharmaceutical Technology & Research, 2015 Much research has been carried out with the aim to discover the therapeutic values of chalcone derivatives. Chalcones possess wide range of pharmacological activity such as antibacterial, antimalarial, antiprotozoal, antitubercular, anticancer, and ...
Deepa Gupta, D K Jain
doaj +1 more source
Synthesis of Antifungal Heterocycle-Containing Mannich Bases: A Comprehensive Review
Organics, 2023 Mannich bases are a class of organic compounds usually obtained by the condensation reaction between an amine, a compound with active hydrogens, and an aldehyde.
Diego Quiroga, Ericsson Coy-Barrera
doaj +1 more source
Quantitative Analysis of Candida Cell Wall Components by Flow Cytometrywith Triple-Fluorescence Staining [PDF]
, 2017 This work was supported by the European Commission within the FP7 Framework Programme [Fungitect-Grant No 602125]. We also thank Thomas Sauer, Vienna Biocenter Campus (VBC), Austria, for technical support at the FACS facility of the MFPL, Karl Kuchler ...
Gow, N +5 more
core +1 more source