British Journal of Clinical Pharmacology, EarlyView.Due to extensive pathophysiological changes in critically ill patients, standard dosing of antibiotics may lead to inadequate drug exposure. This is concerning, as insufficient plasma drug concentrations may lead to treatment failure, whereas excessive drug exposure may increase the risk of toxic adverse events.
Sarah Dräger +12 more
wiley +1 more source
Comparison of antifungal drugs in the treatment of invasive pulmonary aspergillosis: a systematic review and network meta-analysis. [PDF]
Front MicrobiolCheng J +5 more
europepmc +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aims Glycogen storage disease type Ib (GSD‐Ib) is a rare genetic disorder causing neutropenia and neutrophil dysfunction in children. G‐CSF has been the primary treatment, but emerging data support the potential of empagliflozin, an SGLT2 inhibitor, as a promising investigational option.
Elizabeth Iwasyk +5 more
wiley +1 more source
Possibility of re-purposing antifungal drugs posaconazole & isavuconazole against promastigote form of Leishmania major. [PDF]
Indian J Med ResBhusal CK +6 more
europepmc +1 more source
In Vitro Activities of Various Antifungal Drugs against Aspergillus terreus : Global Assessment Using the Methodology of the European Committee on Antimicrobial Susceptibility Testing [PDF]
, 2008 Cornelia Lass‐Flörl +4 more
openalex +1 more source
Challenges in optimizing tacrolimus therapy in patients treated with rifampin: A case series
British Journal of Clinical Pharmacology, EarlyView.Tacrolimus is a cornerstone immunosuppressant in transplantation medicine with a narrow therapeutic window. Drug–drug interactions with strong CYP3A4 and P‐glycoprotein modulators, such as rifampin and azole antifungals, significantly alter tacrolimus exposure and complicate therapy. Two transplant cases illustrates the impact of rifampin on tacrolimus
Jeroen P. A. Houwen +6 more
wiley +1 more source
QTc Interval Prolongation as an Adverse Event of Azole Antifungal Drugs: Case Report and Literature Review. [PDF]
MicroorganismsKitaya S +4 more
europepmc +1 more source
[The pharmacokinetics of oral antifungal drugs and their efficacy against cutaneous mycosis].
, 2005 Satoshi Sobue +2 more
openalex +2 more sources
Pharmacokinetics of antibiotics or antifungal drugs in intensive care units [PDF]
, 2008 Guillaume Dufour, Philippe Montravers
openalex +1 more source
Innovative transdermal drug delivery systems: Benefits, challenges, and emerging application
BMEMat, EarlyView.The graphical abstract illustrates the diverse nanostructures employed in transdermal drug delivery systems, highlighting their unique mechanisms to penetrate the intricate layers of skin. It provides a detailed representation of the skin's complex anatomy, emphasizing the challenges posed by its barrier properties.
Syed Waqas Ali Shah +9 more
wiley +1 more source