Results 61 to 70 of about 3,996,806 (388)

Missed Opportunities for Antifungal Stewardship during the COVID-19 Era

Antibiotics, 2023
Significant increases in antibacterial use were observed during the COVID-19 pandemic. However, subsequent analyses found this increase in antibiotic use to be excessive in comparison with the relatively low rates of bacterial coinfection.
Brandon K. Hawkins, Samantha D. Walker, Mahmoud A. Shorman   +2 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

An insight into new strategies and targets to combat antifungal resistance: A comprehensive review

European Journal of Medicinal Chemistry Reports
Antifungal drugs target specific components or processes within fungal cells to prevent or eliminate their growth. Various antifungal targets exist, including the cell membrane disrupted by drugs such as azoles and polyenes.
Deepali Nahar, Popat Mohite, Ankita Lonkar, Vijay R. Chidrawar, Rajesh Dodiya, Md Jamir Uddin, Sudarshan Singh, Bhupendra G. Prajapati   +7 more
doaj   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Synthesis, characterization and antifungal assessment of optically active bis-organotin compounds derived from (S)-BINOL diesters [PDF]

, 2019
Background: Organotin(IV) derivatives have appeared recently as potential biologically active metallopharmaceuticals exhibiting a variety of therapeutic activities.
Costantino, Andrea Rosana, Koll, Liliana Cristina, Mandolesi, Sandra Delia, Neudörfl, Jörg M., Ocampo, Romina Andrea, Svetaz, Laura Andrea, Zacchino, Susana Alicia Stella   +6 more
core   +1 more source

Medication Use in Multiple Sclerosis: A Population‐Based Comparison With the General Danish Population

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To investigate the overall use of prescription medications among individuals with multiple sclerosis compared to the general population, with a focus on treatments beyond disease‐modifying therapies. Methods We conducted a nationwide, registry‐based study in Denmark.
Josefine Windfeld‐Mathiasen, Henrik Horwitz, Ida M. Heerfordt, Elisabeth Framke, Melinda Magyari   +4 more
wiley   +1 more source

Evaluation of Antifungal Effect of Alcoholic Extract of Achillea Millefolium and Trachyspermum ammi Against Candida albicans Isolated from Denture Stomatitis

پیاورد سلامت, 2022
Background and Aim: Denture stomatitis is the most prevalent oral mucosal lesion among denture wearers. Because there have been multiple reports of resistance of Candida species to antifungal drugs in the last two decades, if the antifungal properties of
Nazli Ebrahim Netaj, Maryam Rezaei Dastjerdi, Saham Ansari, Kamran Amirian Chayjan, Mahdi Sepidarkish, Jalal Jafarzadeh, Akbar Hossein Nejad, Mojtaba Taghizadeh Armaki   +7 more
doaj  

Genomic Variation-Mediating Fluconazole Resistance in Yeast

Biomolecules, 2022
Fungal infections pose a serious and growing threat to public health. These infections can be treated with antifungal drugs by killing hazardous fungi in the body.
Wen-Yao Wang, Hong-Qing Cai, Si-Yuan Qu, Wei-Hao Lin, Cheng-Cheng Liang, Hao Liu, Ze-Xiong Xie, Ying-Jin Yuan   +7 more
doaj   +1 more source

Antimicrobial Activities and Mechanisms of Magnesium Oxide Nanoparticles (nMgO) against Pathogenic Bacteria, Yeasts, and Biofilms. [PDF]

, 2018
Magnesium oxide nanoparticle (nMgO) is a light metal based antimicrobial nanoparticle that can be metabolized and fully resorbed in the body. To take advantage of the antimicrobial properties of nMgO for medical use, it is necessary to determine the ...
Grelling, Nathaniel, Liu, Huinan, Nguyen, Nhu-Y Thi, Rosario, Romeo, Wetteland, Cheyann Lee   +4 more
core   +3 more sources

Unraveling How Candida albicans Forms Sexual Biofilms. [PDF]

, 2020
Biofilms, structured and densely packed communities of microbial cells attached to surfaces, are considered to be the natural growth state for a vast majority of microorganisms.
Hernday, Aaron D, Nobile, Clarissa J, Perry, Austin M   +2 more
core   +1 more source