Results 111 to 120 of about 116,042 (299)

Antifungal Susceptibility Data and Epidemiological Distribution of Candida spp.: An In Vitro Five-Year Evaluation at University Hospital Policlinico of Catania and a Comprehensive Literature Review

Antibiotics
Background: Invasive fungal infections represent a concerning healthcare issue, with Candida spp. reported as the main aetiological agent. Candida spp. bloodstream infections show high mortality rates, indicating increasing antifungal-resistance episodes
Maddalena Calvo, Guido Scalia, Laura Trovato   +2 more
doaj   +1 more source

MARDy: Mycology Antifungal Resistance Database

, 2018
Summary: The increase of antifungal drug resistance is a major global human health concern and threatens agriculture and food security; in order to tackle these concerns, it is important to understand the mechanisms that cause antifungal resistance.
A Abdolrasouli (21905603), A Nash (13658563), RA Farrer (21860186), JMG Shelton (21905606), T Sewell (18382689), J Rhodes (7922804), MC Fisher (21855188)   +6 more
core   +2 more sources

Antifungal Resistance Analysis of Environmental Isolates of Aspergillus in North India

, 2019
Triazoles are the major group of antifungals for treating Aspergillus infections. The morbidity and mortality associated with these infections is high and rate of treatment failure is more in patients infected with azole resistant Aspergillus.
Harshita Agarwal, Maansi Vermani, Shanu Hoda, Simran K. Ahluwalia, Pooja Vijayaraghavan   +4 more
core   +1 more source

A Cationic Supramolecule With Potent Antifungal Activity, Single‐Species Selectivity, and Strong Synergy With Echinocandins

Advanced Science, EarlyView.
We introduce a new membrane‐active antifungal design, Gua‐SMACS‐16, that exhibits high potency and single‐species selectivity for C. tropicalis while sparing other close species in the Candida genus. Moreover, when combining with caspofungin, a clinical antifungal drug inhibiting 1,3‐β‐glucan synthase, they exhibit ultra‐strong synergy across a panel ...
Tianjiao Dai, Adrielle Xianwen Chen, Eve Wai Ling Chow, Li Mei Pang, Jianguo Li, Chandra Shekhar Verma, Stefan H. Oehlers, Yue Wang, Ning Li   +8 more
wiley   +1 more source

Reverse genetics in Candida albicans predicts ARF cycling is essential for drug resistance and virulence [PDF]

, 2010
Peer ...
Mullick, Alaka, Malcolm Whiteway, Jansen, Gregor, Whiteway, Malcolm, David Y Thomas, Harcus Doreen, Lee Anna Y., Vanier, Ghyslaine, Lee, Anna Y., Thomas, David Y, Michael Hallett, Vanier Ghyslaine, Munro, Carol A., Elias Epp, Epp Elias, Gregor Jansen, Thomas, David Y., Ghyslaine Vanier, Jansen Gregor, Harcus, Doreen, Anna Y Lee, Alaka Mullick, Hallett, Michael, Lee, Anna Y, Thomas David Y., Hallett Michael, Whiteway Malcolm, Carol A Munro, Mullick Alaka, Epp, Elias, Don C Sheppard, Sheppard Don C., Munro Carol A., Doreen Harcus, Sheppard, Don C, Sheppard, Don C., Munro, Carol A   +36 more
core   +1 more source

Mechanism‐Informed Machine Learning Enables Discovery of Oncolytic Peptides for Cancer Immunotherapy

Advanced Science, EarlyView.
MISPOP integrates ensemble learning with membrane‐active physicochemical priors to identify Dermaseptin‐S9, a natural oncolytic peptide that disrupts tumor membranes, triggers immunogenic cell death, and shows strong antitumor activity. The study illustrates a mechanism‐informed route from peptide sequence data to cancer immunotherapy leads.
Wen Zhang, Shengxin Lu, Guangyong Zheng, Shensuo Li, Hongyu Chen, Mei Hong, Xiangru Zhou, Ruotian Tang, Ye Wu, Weidong Zhang, Dong Lu, Xin Luan   +11 more
wiley   +1 more source

Phenotypic Impact and Multivariable Assessment of Antifungal Susceptibility in Candida auris Survival Using a Galleria mellonella Model

Journal of Fungi
The novel pathogen Candida auris has rapidly become a major health threat due to its high virulence, resistance to multiple antifungal agents, and remarkable environmental persistence.
Jorge Alvarruiz, Alba Cecilia Ruiz-Gaitán, Marta Dafne Cabanero-Navalon, Javier Pemán, Rosa Blanes-Hernández, Santiago de Cossio, Victor Garcia-Bustos   +6 more
doaj   +1 more source

Targeting ANGPTL3 and IL‐33/ST2 Ameliorates Diabetic Kidney Disease by Reducing Lipotoxicity, Alleviating Inflammation and Inhibiting Fibrosis

Advanced Science, EarlyView.
Dual targeting of ANGPTL3 and IL‐33/ST2 attenuates diabetic kidney disease by reprogramming lipid–inflammatory crosstalk. This strategy reduces renal lipotoxicity, suppresses inflammatory activation, and limits fibrotic remodeling, thereby preserving kidney structure and function and highlighting a mechanism‐guided therapeutic approach for metabolic ...
Zhuojin Li, Zhonglian Cao, Rongrui Zhou, Xu Cheng, Xiaozhi Hu, Shuwen Xu, Zihan Dou, Ling Du, Dianwen Ju   +8 more
wiley   +1 more source

The role of gene copy number variation in antimicrobial resistance in human fungal pathogens

npj Antimicrobials and Resistance
Faced with the burden of increasing resistance to antifungals in many fungal pathogens and the constant emergence of new drug-resistant strains, it is essential to assess the importance of various resistance mechanisms.
Adarsh Jay, David F. Jordan, Aleeza Gerstein, Christian R. Landry   +3 more
doaj   +1 more source

ER stress response mechanisms in the pathogenic yeast Candida glabrata and their roles in virulence

, 2014
The maintenance of endoplasmic reticulum (ER) homeostasis is critical for numerous aspects of cell physiology. Eukaryotic cells respond to the accumulation of misfolded proteins in the ER (ER stress) by activating the unfolded protein response (UPR), an ...
Kohno, Shigeru, Miyazaki, Taiga
core   +1 more source