Results 121 to 130 of about 116,695 (299)

Candida antifungal drug resistance in sub-Saharan African populations: A systematic review [version 1; referees: 2 approved]

F1000Research, 2016
Background: Candida infections are responsible for increased morbidity and mortality rates in at-risk patients, especially in developing countries where there is limited access to antifungal drugs and a high burden of HIV co-infection.
Charlene Wilma Joyce Africa, Pedro Miguel dos Santos Abrantes   +1 more
doaj   +1 more source

Sensitivity and resistance to antifungals [PDF]

Journal of Antimicrobial Chemotherapy, 1985
D C, Speller, D W, Warnock
openaire   +2 more sources

Systemic Nanomechanical Single‐Cell Profiling Reveals Mechanophenotype Transitions Under Therapeutic Perturbation

Advanced Science, EarlyView.
Single‐cell mechanomics demonstrates that pharmacological perturbation changes cytoskeletal and cortical structure, suppressing cancer cell invasiveness. By integrating atomic force microscopy (AFM)‐based cortical measurements with stimulated emission depletion (STED)‐resolved adhesion and cytoskeletal organization, this approach identifies nanoscale ...
Minhee Ku, Jinwon Kwon, Nara Yoon, Hyung Kwon Byeon, Jaemoon Yang   +4 more
wiley   +1 more source

A study on biofilm production and antifungal drug resistance among Candida species from vulvovaginal and bloodstream infections [PDF]

, 2018
Sanyuktha Tulasidas,1 Pooja Rao,2 Sevitha Bhat,2 Radhakrishna Manipura1 1Department of Microbiology, Kasturba Medical College, Manipal Academy of Higher Education, Mangalore, Manipal, India; 2Department of Microbiology, Kasturba Medical College, Manipal ...
Rao P, Tulasidas S, Bhat S, Manipura R
core  

Subversion of Atypical Mucin Traps by a Spore‐Coat Effector Blocks Cellular Immunity in Drosophila

Advanced Science, EarlyView.
While the entomopathogenic fungus Metarhizium robertsii can evade insect humoral immunity, its subversion of cellular defenses is still elusive. We identify Eac1 as a spore‐coat protein essential for infecting drosophilids by targeting atypical mucins (Sgf1 and Sgf2), which can entrap spores in a gel matrix and thereby facilitate hemocyte encapsulation.
Shiqin Li, Haimin Chen, Gangqi Fang, Dongxiang Wei, Hongyun Wu, Chen Chen, Song Hong, Chengshu Wang   +7 more
wiley   +1 more source

Antifungal Resistance in Pulmonary Aspergillosis

Seminars in Respiratory and Critical Care Medicine
AbstractAspergilli may cause various pulmonary diseases in humans, including allergic bronchopulmonary aspergillosis (ABPA), chronic pulmonary aspergillosis (CPA), and acute invasive pulmonary aspergillosis (IPA). In addition, chronic colonization may occur in cystic fibrosis (CF).
Verweij, Paul E, Song, Yinggai, Buil, Jochem B, Zhang, Jianhua, Melchers, Willem J G   +4 more
openaire   +5 more sources

Reverse genetics in Candida albicans predicts ARF cycling is essential for drug resistance and virulence [PDF]

, 2010
Peer ...
Mullick, Alaka, Malcolm Whiteway, Jansen, Gregor, Whiteway, Malcolm, David Y Thomas, Harcus Doreen, Lee Anna Y., Vanier, Ghyslaine, Lee, Anna Y., Thomas, David Y, Michael Hallett, Vanier Ghyslaine, Munro, Carol A., Elias Epp, Epp Elias, Gregor Jansen, Thomas, David Y., Ghyslaine Vanier, Jansen Gregor, Harcus, Doreen, Anna Y Lee, Alaka Mullick, Hallett, Michael, Lee, Anna Y, Thomas David Y., Hallett Michael, Whiteway Malcolm, Carol A Munro, Mullick Alaka, Epp, Elias, Don C Sheppard, Sheppard Don C., Munro Carol A., Doreen Harcus, Sheppard, Don C, Sheppard, Don C., Munro, Carol A   +36 more
core   +1 more source

Oral Delivery Systems for Food‐Derived Bioactive Peptides: Enhancing Stability, Bioavailability, and Health Benefits

Advanced Science, EarlyView.
Advanced delivery systems—including nanoparticles, nanoemulsions, liposomes, and hydrogels—protect food‐derived bioactive peptides from gastrointestinal degradation and bitterness. These systems enable pH‐responsive release, enhance intestinal absorption, and improve therapeutic efficacy against oxidative stress, metabolic disorders, cancer, and ...
Yu Xu, Fan Li, Runan Zhao, Tao Shu, Weihong Min, Bei‐Wei Zhu   +5 more
wiley   +1 more source

Phenotypic Impact and Multivariable Assessment of Antifungal Susceptibility in Candida auris Survival Using a Galleria mellonella Model

Journal of Fungi
The novel pathogen Candida auris has rapidly become a major health threat due to its high virulence, resistance to multiple antifungal agents, and remarkable environmental persistence.
Jorge Alvarruiz, Alba Cecilia Ruiz-Gaitán, Marta Dafne Cabanero-Navalon, Javier Pemán, Rosa Blanes-Hernández, Santiago de Cossio, Victor Garcia-Bustos   +6 more
doaj   +1 more source

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source