Results 251 to 260 of about 183,572 (328)

ThiF‐Like Enzyme Chemistry in Primary and Secondary Metabolism

ChemBioChem, EarlyView.
ThiF‐like enzymes are a widespread protein family found in disparate biosynthetic pathways. They are unified by their use of an NTP to modify a carboxylate, generating an activated species prone to nucleophilic addition. This common intermediate is then targeted by diverse nucleophiles, including persulfide or amino acid side chains, to yield a variety
Keelie S. Butler, Anshul Rajput, Jonathan R. Chekan   +2 more
wiley   +1 more source

From crops to clinic: the impact of dual azole use on antifungal resistance in <i>Candida</i> and <i>Candida</i> associated yeasts. [PDF]

Front Microbiol
Allison JC, Hyland EM.
europepmc   +1 more source

Authors' reply - Antifungal resistance in dermatology

Indian Journal of Dermatology, 2019
Kikkeri Narayanshetty Naveen, Varadraj V Pai, Ajantha Ganavalli   +2 more
openaire   +4 more sources

Synergistic Reduction of Breast Cancer Cell Viability and Aggressiveness Through Dual Inhibition of APE1 Redox Function and STAT3 Signaling

Cell Biology International, EarlyView.
ABSTRACT Aggressiveness and resistance to treatments are significant problems in cancer management. In this scenario, searching for new pharmacological targets for therapies is essential. The APE1 redox domain coactivates transcription factors that favor cancer malignancy. One of APE1's targets, STAT3, coordinates the transcription of genes involved in
Mariana Moreno de Sousa Rodrigues, Priscyanne Barreto Siqueira, Ana Clara Cavallo Dobao, Maria Eduarda Barbosa Mourão, Bruno Ricardo Barreto Pires, Adenilson de Souza da Fonseca, Ísis Salviano Soares de Amorim, Andre Luiz Mencalha   +7 more
wiley   +1 more source

The calcineurin pathway regulates extreme thermotolerance, cell membrane and wall integrity, antifungal resistance, and virulence in Candida auris. [PDF]

PLoS Pathog
Cha H, Won D, Kang S, Kim ES, Lee KA, Lee WJ, Lee KT, Bahn YS.   +7 more
europepmc   +1 more source

Nano Hexagon NiCeO2 for Al–Air Batteries: A Combined Experimental and Density Functional Theory Study of Oxygen Reduction Reaction Activity

ChemElectroChem, EarlyView.
An Al‐air battery employing a NiCeO2 cathode achieves an open‐circuit voltage of 1.65 V, a high discharge capacity of 1070 mAh g−1, and a power density of 77.64 mW cm−2, demonstrating its potential for high‐performance energy storage applications. Nano hexagon NiCeO2 is synthesized via a simple one‐pot hydrothermal method and evaluated as a highly ...
Swathi Tharani Dharmalingam, Parul Sharma, Anurag Prakash Sunda, Manickam Minakshi, R. Sivasubramanian   +4 more
wiley   +1 more source

Symptomatic vulvovaginal candidiasis and antifungal resistance in HIV-1 positive women at Mbarara city health centre IV. [PDF]

Sci Rep
Mbatudde N, Nalumaga PP, Bazira J, Kabanda T.   +3 more
europepmc   +1 more source

CuH‐Catalyzed Asymmetric Desymmetrization of Cyclobutenes via Stereodivergent Hydroamination

ChemistryEurope, EarlyView.
The CuH‐catalyzed stereodivergent hydroamination through asymmetric desymmetrization of cyclobutenes has been achieved, yielding a range of trisubstituted aminocyclobutanes with excellent results. A series of subsequent transformations, including the first asymmetric synthesis of two pharmaceutically active molecules, have been realized, and density ...
Xiang Lei, Peng Luo, Shouang Lan, Wennan Dong, Chao Xu, Jinggong Liu, Shuang Yang, Qi Zhang, Xinqiang Fang   +8 more
wiley   +1 more source

Impact of C18 Epimerization of Indole‐ and Pyrazole‐Fused 18β‐Glycyrrhetinic Acid Derivatives on PTP1B and TCPTP Inhibitory Activity: Synthesis, In Vitro, and In Silico Studies

ChemMedChem, EarlyView.
The indole derivative (FC‐114) and the N‐phenylpyrazole (FC‐122) of glycyrrhetinic acid are both potent inhibitors of the Protein Tyrosine Phosphatase 1B, with IC50 values of 0.48 μM and 1.15 μM, respectively. However, their activity decreases by up to four times when the 18β‐H position is epimerized to 18α‐H or when the carbonyl group at the C11 ...
Ledy De‐la‐Cruz‐Martínez, Rosendo Martínez‐Arellano, Mitzi López‐Sánchez, José G. Alvarado‐Rodríguez, Jesús Martin Torres‐Valencia, David Equihua‐González, Julio‐César Almanza‐Pérez, Jaime Pérez‐Villanueva, Martín González‐Andrade, José C. Páez‐Franco, Francisco Cortés‐Benítez   +10 more
wiley   +1 more source

China's innovative national plan to combat fungal diseases and antifungal resistance. [PDF]

Innovation (Camb)
Xiao M, Zhang L, Wang Y, Feng J, Kong W, Lin L, Xu Y.   +6 more
europepmc   +1 more source