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First Report of <i>Candida auris</i> Candidemia in Portugal: Genomic Characterisation and Antifungal Resistance-Associated Genes Analysis. [PDF]
J Fungi (Basel)Miranda IM +6 more
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Resistance to Antifungal Drugs
Infectious Disease Clinics of North America, 2021Pathogenic fungi have several mechanisms of resistance to antifungal drugs, driven by the genetic plasticity and versatility of their homeostatic responses to stressful environmental cues. We critically review the molecular mechanisms of resistance and cellular adaptations of pathogenic fungi in response to antifungals and discuss the factors ...
Ronen, Ben-Ami +1 more
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Clinical Infectious Diseases, 2003
The increasing incidence of invasive fungal infections is the result of many factors, including an increasing number of patients with severe immunosuppression. Although new drugs have been introduced to combat this problem, the development of resistance to antifungal drugs has become increasingly apparent, especially in patients who require long-term ...
Juergen, Loeffler, David A, Stevens
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The increasing incidence of invasive fungal infections is the result of many factors, including an increasing number of patients with severe immunosuppression. Although new drugs have been introduced to combat this problem, the development of resistance to antifungal drugs has become increasingly apparent, especially in patients who require long-term ...
Juergen, Loeffler, David A, Stevens
openaire +2 more sources
Antifungal resistance: more research needed
The Lancet, 2014We welcome the efforts of the Antimicrobial Resistance Funders' Forum, led by the UK Medical Research Council, to coordinate approaches for research on antimicrobial resistance, as reported by Geoff Watts (Aug 2, p 391).1 However, we wish to voice our concerns at the apparent restriction of these efforts to antibacterial resistance.
Barnes, Rosemary A. +4 more
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Resistance to antifungal therapies
Essays in Biochemistry, 2017The evolution of antifungal resistance among fungal pathogens has rendered the limited arsenal of antifungal drugs futile. Considering the recent rise in the number of nosocomial fungal infections in immunocompromised patients, the emerging clinical multidrug resistance (MDR) has become a matter of grave concern for medical professionals.
Rajendra, Prasad +2 more
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Resistance to Antifungal Agents
Pediatric Clinics of North America, 1995The marked increase in the number of patients with AIDS and other forms of immunocompromise has resulted in the emergence of fungi as predominant pathogens in many institutions. Unfortunately, with the widespread use of antifungal agents to combat these infections, reports of resistance to antifungal agents have proliferated. In the present environment,
G P, DeMuri, M K, Hostetter
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Update on antifungal resistance
Trends in Microbiology, 1997Overuse of antifungal agents has resulted in the selection of naturally resistant Candida species, as well as expression of resistance from previously susceptible species resulting from genetic mutations and/or selection of resistant subpopulations.
M E, Klepser, E J, Ernst, M A, Pfaller
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Antifungal Drug Resistance in Aspergillus
Journal of Infection, 2000This article overviews the emerging problem of antifungaldrug resistance in Aspergillus. Fluconazole and ketocona-zole (KCZ) are inactive against Aspergillus. Validation oftesting procedures for the detection of itraconazole (ITZ)resistance in Aspergillus fumigatusin 19971,2were furthervalidated with posaconazole (SCH-56592)3,4and voricona-zole (VCZ)5 ...
Moore, C.B. +4 more
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