Results 251 to 260 of about 2,517,016 (285)

Antifungal resistance: more research needed

The Lancet, 2014
We welcome the efforts of the Antimicrobial Resistance Funders' Forum, led by the UK Medical Research Council, to coordinate approaches for research on antimicrobial resistance, as reported by Geoff Watts (Aug 2, p 391).1 However, we wish to voice our concerns at the apparent restriction of these efforts to antibacterial resistance.
Barnes, Rosemary A., Gow, N.A.R., Denning, D.W., May, R.C., Haynes, K.   +4 more
openaire   +3 more sources

Molecular basis of antifungal drug resistance in yeasts [PDF]

International Journal of Antimicrobial Agents, 2017
International audienceBesides inherent differences in in vitro susceptibilities, clinically-relevant yeast species may acquire re-sistance upon exposure to most antifungal drugs used in the clinic.
Patrice Le Pape, Maiken C Arendrup, Florent Morio   +2 more
exaly   +2 more sources

Emerging Issues in Antifungal Resistance

Infectious Disease Clinics of North America, 2020
Invasive fungal diseases continue to cause substantial mortality in the enlarging immunocompromised population. It is fortunate that the field has moved past amphotericin B deoxycholate as the only available antifungal drug but despite new classes of antifungal agents both primary and secondary drug resistance in molds and yeasts abound.
John R, Perfect, Mahmoud, Ghannoum
openaire   +2 more sources

Antifungal Resistance Mechanisms in Dermatophytes

Mycopathologia, 2008
Although fungi do not cause outbreaks or pandemics, the incidence of severe systemic fungal infections has increased significantly, mainly because of the explosive growth in the number of patients with compromised immune system. Thus, drug resistance in pathogenic fungi, including dermatophytes, is gaining importance.
Nilce M, Martinez-Rossi, Nalu T A, Peres, Antonio, Rossi   +2 more
openaire   +2 more sources

Antifungal drug resistance mechanisms

Expert Review of Anti-infective Therapy, 2009
Antifungal resistance is a prominent feature in the management of invasive mycoses, with important implications for morbidity and mortality. Microbiological resistance, the most common cause of refractory infection, is associated with a fungal pathogen for which an antifungal MIC is higher than average or within the range designated as the resistant ...
Peman, Javier, Canton, Emilia, Espinel-Ingroff, Ana   +2 more
openaire   +4 more sources

Evolution of antifungal resistance in the environment

Nature Microbiology
The emergence of drug-resistant fungal infections in agriculture and healthcare settings has caused severe implications for food security, public health and natural environments. They pose a substantial hazard for at-risk patient populations who often acquire serious and sometimes life-threatening infections.
Norman van Rhijn, Johanna Rhodes
exaly   +3 more sources

Outwitting Multidrug Resistance to Antifungals

Science, 2008
The economic cost of fungal infection and its mortality associated with multidrug resistance remain unacceptably high. Recent understanding of the transcriptional regulation of plasma membrane efflux pumps of modest specificity provides new avenues for the development of broad-spectrum fungicides.
Brian C, Monk, Andre, Goffeau
openaire   +2 more sources

Treatment of onychomycosis in an era of antifungal resistance: Role for antifungal stewardship and topical antifungal agents

Mycoses
A growing body of literature has marked the emergence and spread of antifungal resistance among species of Trichophyton , the most prevalent cause of toenail and fingernail onychomycosis in the United States and Europe.
Antonella Tosti, Shari R Lipner
exaly   +2 more sources

Clinical relevance of resistance to antifungals

International Journal of Antimicrobial Agents, 2008
The standardization of antifungal sensitivity tests represents a huge advance in the detection of antifungal drug resistance. Thus, the reference methods of the European Committee on Antibiotic Susceptibility Testing and the Clinical Laboratory Standards Institute have proven capable of detecting strains of yeasts and filamentous fungi with high ...
Juan Luis, Rodriguez-Tudela, Laura, Alcazar-Fuoli, Isabel, Cuesta, Ana, Alastruey-Izquierdo, Araceli, Monzon, Emilia, Mellado, Manuel, Cuenca-Estrella   +6 more
openaire   +2 more sources

Antifungal Drugs and Resistance

1995
From the late 1950’s, extending for two decades thereafter, amphotericin B was the only broad spectrum antifungal drug which could be systemically administered. Because it was the only option, and because systemic mycoses were relatively infrequent, there was little interest in understanding the mechanism of action of amphotericin B, or expanding ...
openaire   +2 more sources