Results 271 to 280 of about 190,632 (309)

Emerging Issues in Antifungal Resistance

Infectious Disease Clinics of North America, 2020
Invasive fungal diseases continue to cause substantial mortality in the enlarging immunocompromised population. It is fortunate that the field has moved past amphotericin B deoxycholate as the only available antifungal drug but despite new classes of antifungal agents both primary and secondary drug resistance in molds and yeasts abound.
John R, Perfect, Mahmoud, Ghannoum
openaire   +2 more sources

Antifungal resistance in mucorales

International Journal of Antimicrobial Agents, 2017
The order Mucorales, which includes the agents of mucormycosis, comprises a large number of species. These fungi are characterised by high-level resistance to most currently available antifungal drugs. Standardised antifungal susceptibility testing methods are now available, allowing a better understanding of the in vitro activity of antifungal drugs ...
openaire   +2 more sources

Antifungal Resistance Mechanisms in Dermatophytes

Mycopathologia, 2008
Although fungi do not cause outbreaks or pandemics, the incidence of severe systemic fungal infections has increased significantly, mainly because of the explosive growth in the number of patients with compromised immune system. Thus, drug resistance in pathogenic fungi, including dermatophytes, is gaining importance.
Nilce M, Martinez-Rossi, Nalu T A, Peres, Antonio, Rossi   +2 more
openaire   +2 more sources

Antifungal Drugs and Resistance

1995
From the late 1950’s, extending for two decades thereafter, amphotericin B was the only broad spectrum antifungal drug which could be systemically administered. Because it was the only option, and because systemic mycoses were relatively infrequent, there was little interest in understanding the mechanism of action of amphotericin B, or expanding ...
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Outwitting Multidrug Resistance to Antifungals

Science, 2008
The economic cost of fungal infection and its mortality associated with multidrug resistance remain unacceptably high. Recent understanding of the transcriptional regulation of plasma membrane efflux pumps of modest specificity provides new avenues for the development of broad-spectrum fungicides.
Brian C, Monk, Andre, Goffeau
openaire   +2 more sources

Body heat drives antifungal resistance

Nature Microbiology
Multi-drug resistance and virulence in Rhodosporidiobolus fluvialis, an emergent human fungal pathogen that causes fungaemia, is driven by body-temperature-induced elevated mutation rates.
Michael J. Bottery, David W. Denning
openaire   +3 more sources

CLINICAL RELEVANCE OF ANTIFUNGAL RESISTANCE

Infectious Disease Clinics of North America, 1997
The availability of standard guidelines (NCCLS M27 document) for antifungal susceptibility testing has facilitated the establishment of tentative interpretive breakpoints for fluconazole and itraconazole by the NCCLS. Based on correlations of MIC values with the outcomes of patients with mostly Candida infections, fluconazole MICs of > or = 64 and ...
openaire   +2 more sources

Antifungal resistance

2020
Indranil Samanta, Samiran Bandyopadhyay
openaire   +1 more source

Tackling the emerging threat of antifungal resistance to human health

Nature Reviews Microbiology, 2022
Matthew C Fisher, Ana Alastruey-Izquierdo, Judith G Berman   +2 more
exaly  

Antibiotic resistance in the patient with cancer: Escalating challenges and paths forward

Ca-A Cancer Journal for Clinicians, 2021
Amila K Nanayakkara, Kevin Outterson
exaly