Results 71 to 80 of about 66,504 (305)

How to: perform antifungal susceptibility testing of microconidia-forming dermatophytes following the new reference EUCAST method E.Def 11.0, exemplified by Trichophyton [PDF]

, 2021
Background: Antifungal drug resistance in dermatophytes was first reported shortly after the turn of the millennium and has today been reported in Trichophyton and occasionally in Microsporum, but not in Epidermophyton species.
Velegraki, A., the Subcommittee on Antifungal Susceptibility Testing (AFST) of the ESCMID European Committee for Antimicrobial Susceptibility Testing (EUCAST), Kurzai, O., Meletiadis, J., Rogers, T.R., Castanheira, M., Barchiesi, F., Moore, C.B., Lass-Florl, C., Muehlethaler, K., Arendrup, M.C., Friberg, F., Klimko, N., Kahlmeter, G., Guinea, J., Hamal, P., Lagrou, K., Jarv, H., Hilmarsdottir, I., Arikan-Akdagli, S., Matos, T.   +20 more
core  

Antifungal susceptibility profile and local epidemiological cut-off values of Yarrowia (Candida) lipolytica: an emergent and rare opportunistic yeast

Microbiology Spectrum
The antifungal susceptibility profile and epidemiological cut-off values (ECOFFs) of Yarrowia lipolytica, a rare opportunistic yeast, remain unclear.
Jinhan Yu, Xueqing Liu, Dawen Guo, Wenhang Yang, Xinfei Chen, Guiling Zou, Tong Wang, Shichao Pang, Ge Zhang, Jingjing Dong, Yingchun Xu, Ying Zhao   +11 more
doaj   +1 more source

De Novo Design of Membrane‐Targeting Antimicrobial Peptides Against Gram‐Negative Bacteria Using a Generative Artificial Intelligence Framework

Advanced Science, EarlyView.
Antimicrobial resistance caused by Gram‐negative bacteria remains difficult to overcome due to the protective outer membrane. To address this challenge, a multi‐condition constrained generative AI framework, GenMTAMP is proposed for de novo membrane‐targeting antimicrobial peptide design by integrating physicochemical and spatial structure descriptors.
Jingxiao Yu, Da‐Wen Sun, QingYi Wei, Yibing Zhang, Jidong Tang, Hongbin Pu   +5 more
wiley   +1 more source

Comparison of results of fluconazole and voriconazole disk diffusion testing for Candida spp. with results from a central reference laboratory in the ARTEMIS DISK Global Antifungal Surveillance [PDF]

, 2009
The accuracy of antifungal susceptibility testing is important for reliable resistance surveillance and for the clinical management of patients with serious infections due to Candida spp.
KROEGER J, HOLLIS RJ, TENDOLKAR S, PARTICIPANT OF GLOBAL ANTIFUNGAL SURVEILLANCE GROUP, GHEZZI, Maria Cristina, MESSER SA, RAPONI, Giammarco, DIEKEMA DJ, PFALLER MA, BOYKEN L   +9 more
core   +1 more source

ASSESSMENT OF SPECIATION AND ANTIFUNGAL SUSCEPTIBILITY TESTING IN THE INTENSIVE CARE UNIT: AN OBSERVATIONAL CROSS-SECTIONAL STUDY DESIGN.

Student's Journal of Health Research Africa, 2023
Objectives:  This study aims to investigate the epidemiology of Candidemia in patients admitted to Intensive Care Units (ICUs), focusing on the distribution of species, antifungal susceptibility patterns, and demographic factors.
Bhuvan Shome, Ashok Kumar Sharma, Kumari Seema, Abhay Kumar, Manoj Kumar, Manju Boipai   +5 more
doaj   +1 more source

Calcineurin‐Dependent Stress Adaptation Enables Caspofungin Heteroresistance Leading to Stable Resistance in Candida Glabrata

Advanced Science, EarlyView.
Caspofungin heteroresistance is prevalent in clinical Candida glabrata isolates and depends on calcineurin‐mediated stress adaptation. This transient phenotype serves as a reservoir for resistance evolution, enabling the emergence of stable resistant descendants under prolonged drug pressure.
Yanyu Su, Yi Li, Meng Xiao, Dan Guo, David S. Perlin, Erika Shor, Yingchun Xu, Yingxing Li   +7 more
wiley   +1 more source

The Evolving Role of Antifungal Susceptibility Testing [PDF]

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 2013
Although increasing numbers of hospital microbiology laboratories are performing antifungal susceptibility testing ( AST ), its routine use is uncommon. The utility of AST is founded on the belief that susceptibility (or resistance) of an agent allows ...
Eschenauer, Gregory A., Carver, Peggy L.
openaire   +3 more sources

Kaempferol Attenuates Spaceflight‐Associated Knee Cartilage Degradation by Targeting NOX4‐Mediated Mitochondrial Dysfunction

Advanced Science, EarlyView.
We have shown that both simulated and actual spaceflight contribute to cartilage degradation in the knees of mice. Using RNA sequencing and bioenergetic profiling, we identified NADPH oxidase 4 (NOX4) as a key factor driving these changes. Additionally, we found that kaempferol, a naturally occurring flavonoid that binds directly to NOX4, reduces ...
Yuesong Yin, Ruiling Xu, Meagan J. Makarczyk, Jia‐Jun Liu, Silvia Liu, Matthew Z. Shi, Roberta Di Carlo, Michael F. Almeida, Alex Garris, Sarah Day, Rebekah Sanchez‐Hodge, Jonathan C. Schisler, Aleeza H. Zilberman, Noah G. Allen, Angela J. Kubik, Elizabeth A. Blaber, Arnold Z. Olali, Wanqing Xie, Douglas C. Wallace, Christopher E. Mason, Peter G. Alexander, Giuseppe Intini, Afshin Beheshti, Hang Lin   +23 more
wiley   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Carbohydrate derived fulvic acid: an in vitro investigation of a novel membrane active antiseptic agent against Candida albicans biofilms [PDF]

, 2012
Carbohydrate derived fulvic acid (CHD-FA) is a heat stable low molecular weight, water soluble, cationic, colloidal material with proposed therapeutic properties.
Brian Jones, Murray, Colin, Bagg, Jeremy, Craig eWilliams, Leighann eSherry, Jones, Brian, Owain Millington, Jose, Anto, Gordon eRamage, Millington, Owain, Leighann Sherry, Anto Jose, Jeremy Bagg, Sherry, Leighann, Colin eMurray, Ramage, Gordon, Colin Murray, Williams, Craig, Anto eJose, Owain eMillington, Brian eJones, Gordon Ramage, Jeremy eBagg, Craig Williams   +23 more
core   +1 more source