Results 251 to 260 of about 63,671 (266)

Pharmacogenomics of triazole antifungal agents: implications for safety, tolerability and efficacy

Expert Opinion on Drug Metabolism & Toxicology, 2017
Triazole antifungal agents are prescribed to treat invasive fungal infections in neutropenic and non-neutropenic patients. These antifungal agents are substrates and inhibitors of cytochrome P450 (CYP). Genetic polymorphisms in CYP2C9, CYP2C19 and CYP3A5 can lead to large population-specific variations in drug efficacy and safety, optimal dosing, or ...
Jarrett R, Amsden, Paul O, Gubbins
openaire   +2 more sources

Topical polyene antifungals in hematopoietic cell transplant patients: tolerability and efficacy

Supportive Care in Cancer, 2004
The effectiveness of amphotericin B oral suspension versus nystatin oral suspension for the prevention of oral colonization by Candida in hematopoietic cell transplant (HCT) patients was examined.Prior to hematopoietic cell infusion, 40 patients receiving systemic fluconazole for prophylaxis were randomized to receive either amphotericin B oral ...
Joel B, Epstein   +8 more
openaire   +2 more sources

Antifungal activity of glyphosate against fungal blast disease on glyphosate-tolerant OsmEPSPS transgenic rice

Plant Science, 2021
Weeds, pests, and pathogens are among the pre-harvest constraints in rice farming across rice-growing countries. For weed management, manual weeding and herbicides are widely practiced. Among the herbicides, glyphosate [N-(phosphonomethyl) glycine] is a broad-spectrum systemic chemical extensively used in agriculture.
Sahil Mehta   +9 more
openaire   +2 more sources

Safety and Tolerability of High-dose Weekly Liposomal Amphotericin B Antifungal Prophylaxis

Pediatric Infectious Disease Journal, 2014
Children with hematologic malignancies are at an increased risk of invasive fungal infections and a greater risk has been seen with exposure to building construction. Prophylaxis with high-dose (IV) liposomal amphotericin B (L-AmB) 10 mg/kg once weekly was initiated in our high risk children based on previous pharmacokinetic studies.
Elizabeth O, Hand   +1 more
openaire   +2 more sources

Confronting antifungal resistance, tolerance, and persistence: Advances in drug target discovery and delivery systems

Advanced Drug Delivery Reviews, 2023
Human pathogenic fungi pose a serious threat to human health and safety. Unfortunately, the limited number of antifungal options is exacerbated by the continuous emergence of drug-resistant variants, leading to frequent drug treatment failures. Recent studies have also highlighted the clinical importance of other modes of fungal survival of antifungal ...
Lei, Chen   +7 more
openaire   +2 more sources

A systematic review of the antifungal effectiveness and tolerability of amphotericin B formulations

Clinical Therapeutics, 2003
A systematic review was performed to compare the effectiveness and tolerability of lipid-based amphotericin B (AmB) formulations and conventional AmB in the treatment of systemic fungal infections.The literature and unpublished studies were searched using MEDLINE, EMBASE, Biological Abstracts, AIDSLINE, CANCERLIT, CRD database, Cochrane Controlled ...
Barrett, Jane P.   +12 more
openaire   +4 more sources

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