Results 101 to 110 of about 1,150,155 (343)

Immune-system inspired approach for decentralized multi-agent control [PDF]

open access: yes, 2016
This paper contains the first steps towards the development of a fully decentralized system framework. The novel approach that has been taken is derived from the inherent properties of the immune system. An assessment of the proposed control architecture
German, S.   +2 more
core   +1 more source

Efficient and selective presentation of antigen-antibody complexes by rheumatoid factor B cells

open access: yesJournal of Experimental Medicine, 1991
Using Epstein-Barr virus B cell clones and antigen-specific T cell clones, we asked how antigen-antibody complexes are handled by B cells. We found that the only B cells capable of efficient presentation of antigen-antibody complexes are those that bind ...
E. Roosnek, A. Lanzavecchia
semanticscholar   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan   +10 more
wiley   +1 more source

Immunization of mice with YscF provides protection from Yersinia pestis infections

open access: yesBMC Microbiology, 2005
Background Yersinia pestis, the causative agent of plague, is a pathogen with a tremendous ability to cause harm and panic in populations. Due to the severity of plague and its potential for use as a bioweapon, better preventatives and therapeutics for ...
Bradley David S   +3 more
doaj   +1 more source

Antigen depot is not required for alum adjuvanticity [PDF]

open access: yes, 2012
Alum adjuvants have been in continuous clinical use for more than 80 yr. While the prevailing theory has been that depot formation and the associated slow release of antigen and/or inflammation are responsible for alum enhancement of antigen presentation
Abigail H. Pollock   +11 more
core   +2 more sources

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

open access: yesMolecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim   +8 more
wiley   +1 more source

Potentiating Antigen-Specific Antibody Production with Peptides Obtained from In Silico Screening for High-Affinity against MHC-II

open access: yesMolecules, 2019
Monoclonal antibodies with high affinity and specificity are essential for research and clinical purposes, yet remain difficult to produce. Agretope peptides that can potentiate antigen-specific antibody production have been reported recently.
Yoshiro Hanyu, Yuto Komeiji, Mieko Kato
doaj   +1 more source

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

open access: yesMolecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu   +15 more
wiley   +1 more source

Constante de Afinidade em Radioimunoanalise.

open access: yesActa Médica Portuguesa, 1990
Values for the affinity constant were determined, in three kits, for seric gastrin, following the Scatchard plot and Michaelis-Menten representation. The determination of the affinity constant, K, is of great value for it defines the antigen-antibody ...
M A Ferra, C N Leitão
doaj   +1 more source

Immunization and Aging: a Learning Process in the Immune Network

open access: yes, 1998
The immune system can be thought as a complex network of different interacting elements. A cellular automaton, defined in shape-space, was recently shown to exhibit self-regulation and complex behavior and is, therefore, a good candidate to model the ...
A. Coutinho   +12 more
core   +1 more source

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