Results 261 to 270 of about 1,150,155 (343)

Mimicking Biochemical Traits with a Synthetic Lipid Nanoparticles SARS‐COV‐2 Model

Advanced Therapeutics, EarlyView.
A synthetic virus model developed using lipid nanoparticles, which incorporate encapsulated mRNA and nucleocapsid (N) protein along with surface‐conjugated spike (S) protein, mimics the characteristics of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), allowing for the advancement of diagnostic product assessment.
Ignasia Handipta Mahardika, Hyun Park, Eunjin Huh, Changyoon Baek, Shin‐Gyu Cho, Kwang‐Hwan Jung, Junhong Min, Kwanwoo Shin   +7 more
wiley   +1 more source

The recent advances in vaccine adjuvants. [PDF]

Front Immunol
Xing J, Zhao X, Li X, Fang R, Sun M, Zhang Y, Song N.   +6 more
europepmc   +1 more source

Emerging Therapeutic Strategies for Hearing Loss

Advanced Therapeutics, EarlyView.
Challenges still exist in treating hearing loss in cases of severe damage to hair cells or spiral ganglion neurons. Here, a schematic diagram of cochlear sensory hair cells and auditory nerves is presented. It is found that in normal Corti organs, hair cells have upright stereocilia at the top and auditory neurons at the base. Ototoxic drugs, noise, or
Shanying Han, Tian Shen, Weiwei He, Hao Wei, Xiaolong Zhao, Wen Yang, Chuan Bu, Xinghua Tang, Yu Zhao, Jiangang Fan   +9 more
wiley   +1 more source

Passive Immunization in the Prevention and Treatment of Viral Infections. [PDF]

Eur J Immunol
Moirangthem R, Bar-On Y.
europepmc   +1 more source

Immune Checkpoint PD‐L1 Modulates Retinal Microglial Activation to Alleviate Vascular Leakage in Choroidal Neovascularization via ERK

Advanced Science, EarlyView.
PD‐L1 limits neuroinflammation in neovascular AMD by modulating microglial activation. Its deficiency exacerbates vascular leakage and choroidal neovascularization (CNV) via ERK signaling, while enhancing PD‐L1 reduces inflammation and neovascularization. Targeting PD‐L1 may offer a novel immunomodulatory strategy for NVAMD.
Yue Zou, Junliang Jiang, Yunqin Li, Xinyi Ding, Qiuping Tong, Ying Shi, Lei Xiao, Ling Chen   +7 more
wiley   +1 more source

Enhancing Shiga toxin detection using surface plasmon resonance a study of antibody immobilization strategies. [PDF]

Sci Rep
Karbalaee Z, Rezayan AH, Taheri RA, Mirhosseini SA, Barshan-Tashnizi M.   +4 more
europepmc   +1 more source

Hydrophobin‐Coated Echogenic Microbubbles for Molecular Targeting of Tumor Cells

Advanced Science, EarlyView.
Echogenic microbubbles based on hydrophobin and corresponding fusion protein (HFBI‐domZ) are developed as contrast agents for cancer diagnostics. Hydrophobin provides high stabilization of encapsulated perfluoro‐n‐butane, and fusion proteins allow further versatile functionalization with antibodies. In‐vitro experiments indicate that these microbubbles
Hedar H. Al‐Terke, Grégory Beaune, Muhammad Junaid, Jani Seitsonen, Arja Paananen, Pierangelo Metrangolo, Jaakko V. I. Timonen, Jussi Joensuu, Robin H. A. Ras   +8 more
wiley   +1 more source

Accelerating antibody discovery and optimization with high-throughput experimentation and machine learning. [PDF]

J Biomed Sci
Matsunaga R, Tsumoto K.
europepmc   +1 more source

AAVR Expression is Essential for AAV Vector Transduction in Sensory Hair Cells

Advanced Science, EarlyView.
Decreased sensitivity to AAV vector transduction in the outer hair cells (OHCs) of adult mice is primarily attributed to reduction of AAVR (Kiaa0319l; Au040320). Knockout of AAVR reduces AAV vector transduction efficiency in both inner hair cells (IHCs) and OHCs in neonatal mice.
Fan Wu, Guisheng Chen, Rui Hu, Peiwen Liu, Jintao Lou, Wenji Zhao, Zuhong He, Suhua Sha, Yiqing Zheng   +8 more
wiley   +1 more source

Molecular characterization of a synthetic neutralizing antibody targeting p67 of Theileria parva. [PDF]

Protein Sci
Miersch S, Singer AU, Chen C, Fellouse F, Gopalsamy A, Costa LSE, Lacasta A, Chege H, Chege N, Nene V, Sidhu SS.   +10 more
europepmc   +1 more source